Guided bone regeneration: materials and biological mechanisms revisited

Guided bone regeneration (GBR) is commonly used in combination with the installment of titanium implants. The application of a membrane to exclude non‐osteogenic tissues from interfering with bone regeneration is a key principle of GBR. Membrane materials possess a number of properties which are ame...

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Vydáno v:European journal of oral sciences Ročník 125; číslo 5; s. 315 - 337
Hlavní autoři: Elgali, Ibrahim, Omar, Omar, Dahlin, Christer, Thomsen, Peter
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Wiley Subscription Services, Inc 01.10.2017
John Wiley and Sons Inc
Témata:
alveolar ridge augmentation
Animals
anorganic bovine
asymmetric porous
beta-tricalcium phosphate
Biocompatibility
biocompatible materials
Biocompatible Materials - pharmacology
Biological properties
Biomaterials Science
Biomaterialvetenskap
Biomedical materials
bone
Bone growth
Bone Regeneration - physiology
calcium-sulfate barrier
controlled clinical-trial
Data processing
Dental Implants
growth factors
guided bone regeneration
Guided Tissue Regeneration - methods
Humans
Literature reviews
Mechanical properties
membrane
Membranes
Membranes, Artificial
occlusive titanium barrier
Odontologi
Odontology
Optimization
osseointegration
Osseointegration - physiology
platelet-rich fibrin
randomized controlled-trial
Regeneration
Regeneration (physiology)
resorbable polymeric membranes
Review
structure
Surgical implants
Tissues
Titanium
Titanium - chemistry
guided bone regeneration
biocompatible materials
membrane
growth factors
osseointegration
ISSN:0909-8836, 1600-0722, 1600-0722
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Popis
Shrnutí:Guided bone regeneration (GBR) is commonly used in combination with the installment of titanium implants. The application of a membrane to exclude non‐osteogenic tissues from interfering with bone regeneration is a key principle of GBR. Membrane materials possess a number of properties which are amenable to modification. A large number of membranes have been introduced for experimental and clinical verification. This prompts the need for an update on membrane properties and the biological outcomes, as well as a critical assessment of the biological mechanisms governing bone regeneration in defects covered by membranes. The relevant literature for this narrative review was assessed after a MEDLINE/PubMed database search. Experimental data suggest that different modifications of the physicochemical and mechanical properties of membranes may promote bone regeneration. Nevertheless, the precise role of membrane porosities for the barrier function of GBR membranes still awaits elucidation. Novel experimental findings also suggest an active role of the membrane compartment per se in promoting the regenerative processes in the underlying defect during GBR, instead of being purely a passive barrier. The optimization of membrane materials by systematically addressing both the barrier and the bioactive properties is an important strategy in this field of research.
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These authors contributed equally to the study.
ISSN:0909-8836
1600-0722
1600-0722
DOI:10.1111/eos.12364