ER stress and unfolded protein response in ocular health and disease

The human eye is the organ that is able to react to light in order to provide sharp three‐dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental changes, genetic mutations, or aging. Endoplasmic reti...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	The FEBS journal Ročník 286; číslo 2; s. 399 - 412
Hlavní autoři:	Kroeger, Heike, Chiang, Wei‐Chieh, Felden, Julia, Nguyen, Amanda, Lin, Jonathan H.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Blackwell Publishing Ltd 01.01.2019
Témata:	achromatopsia Aging AMD Animal models Animals color Endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - pathology Endoplasmic Reticulum Stress Environmental changes ER stress Eye - metabolism Eye diseases Eye Diseases - physiopathology eyes glaucoma Humans Mutation neurodegernation Organic chemistry Protein folding Proteins retinal degeneration RGC RPE Signal Transduction Stress Unfolded Protein Response UPR VEGF vision retinal degeneration RPE UPR VEGF glaucoma AMD ER stress achromatopsia neurodegernation RGC
ISSN:	1742-464X, 1742-4658, 1742-4658
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	The human eye is the organ that is able to react to light in order to provide sharp three‐dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental changes, genetic mutations, or aging. Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signaling have been detected in many diverse ocular diseases, and chemical and genetic approaches to modulate ER stress and specific UPR regulatory molecules have shown beneficial effects in animal models of eye disease. This review highlights specific eye diseases associated with ER stress and UPR activity, based on a recent symposia exploring this theme. The Human eye is a vulnerable organ in the body. Many factors can impact the health of the human eye leading to changes in the quality of our vision. The presence of Endoplasmic reticulum stress and the induction of the Unfolded Protein Response are hallmarks of many retinal diseases; and may be potential mechanisms for therapeutic intervention.
AbstractList	The human eye is the organ that is able to react to light in order to provide sharp three-dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental changes, genetic mutations, or aging. Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signaling have been detected in many diverse ocular diseases, and chemical and genetic approaches to modulate ER stress and specific UPR regulatory molecules have shown beneficial effects in animal models of eye disease. This review highlights specific eye diseases associated with ER stress and UPR activity, based on a recent symposia exploring this theme. The human eye is the organ that is able to react to light in order to provide sharp three-dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental changes, genetic mutations, or aging. Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signaling have been detected in many diverse ocular diseases, and chemical and genetic approaches to modulate ER stress and specific UPR regulatory molecules have shown beneficial effects in animal models of eye disease. This review highlights specific eye diseases associated with ER stress and UPR activity, based on a recent symposia exploring this theme.The human eye is the organ that is able to react to light in order to provide sharp three-dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental changes, genetic mutations, or aging. Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signaling have been detected in many diverse ocular diseases, and chemical and genetic approaches to modulate ER stress and specific UPR regulatory molecules have shown beneficial effects in animal models of eye disease. This review highlights specific eye diseases associated with ER stress and UPR activity, based on a recent symposia exploring this theme. The human eye is the organ that is able to react to light in order to provide sharp three‐dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental changes, genetic mutations, or aging. Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) signaling have been detected in many diverse ocular diseases, and chemical and genetic approaches to modulate ER stress and specific UPR regulatory molecules have shown beneficial effects in animal models of eye disease. This review highlights specific eye diseases associated with ER stress and UPR activity, based on a recent symposia exploring this theme. The Human eye is a vulnerable organ in the body. Many factors can impact the health of the human eye leading to changes in the quality of our vision. The presence of Endoplasmic reticulum stress and the induction of the Unfolded Protein Response are hallmarks of many retinal diseases; and may be potential mechanisms for therapeutic intervention. The human eye is the organ that is able to react to light in order to provide sharp three‐dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental changes, genetic mutations, or aging. Endoplasmic reticulum ( ER ) stress and unfolded protein response ( UPR ) signaling have been detected in many diverse ocular diseases, and chemical and genetic approaches to modulate ER stress and specific UPR regulatory molecules have shown beneficial effects in animal models of eye disease. This review highlights specific eye diseases associated with ER stress and UPR activity, based on a recent symposia exploring this theme.
Author	Felden, Julia Nguyen, Amanda Kroeger, Heike Chiang, Wei‐Chieh Lin, Jonathan H.
AuthorAffiliation	2 Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tübingen, Germany 3 VA San Diego Healthcare System, San Diego, CA, USA 1 Department of Pathology, University of California San Diego, La Jolla, CA, USA
AuthorAffiliation_xml	– name: 1 Department of Pathology, University of California San Diego, La Jolla, CA, USA – name: 3 VA San Diego Healthcare System, San Diego, CA, USA – name: 2 Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tübingen, Germany
Author_xml	– sequence: 1 givenname: Heike surname: Kroeger fullname: Kroeger, Heike email: hkroeger@ucsd.edu organization: University of California San Diego – sequence: 2 givenname: Wei‐Chieh surname: Chiang fullname: Chiang, Wei‐Chieh organization: University of California San Diego – sequence: 3 givenname: Julia surname: Felden fullname: Felden, Julia organization: University of Tübingen – sequence: 4 givenname: Amanda surname: Nguyen fullname: Nguyen, Amanda organization: University of California San Diego – sequence: 5 givenname: Jonathan H. surname: Lin fullname: Lin, Jonathan H. organization: VA San Diego Healthcare System
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29802807$$D View this record in MEDLINE/PubMed
BookMark	eNqNkVuLFDEQhYOsuBd98QdIgy8izJqk00nnRdB1VoUFwQv4FqrTFSdLJplNupX992Z21kEXEfOSgvrqUHXOMTmIKSIhjxk9ZfW9cDiUUyY6zu-RI6YEXwjZ9Qf7Wnw9JMelXFLadkLrB-SQ657ynqoj8mb5sSlTxlIaiGMzR5fCiGOzyWlCH5va2aRYsKl1snOA3KwQwrS6wUdfEAo-JPcdhIKPbv8T8uV8-fns3eLiw9v3Z68uFrYTii8GqZnrFJfj4Jizfat7DZpTRgc-KJBAtR0A5ADMabAaFJVSokDlWgc9tCfk5U53Mw9rHC3GKUMwm-zXkK9NAm_-7ES_Mt_Sd1PtaDVlVeDZrUBOVzOWyax9sRgCRExzMZxzRiUV7X-gtBreV_t1RZ_eQS_TnGN1wnCmaKcEE1vBJ78vv9_6VxYVeL4DbE6lZHR7hFGzDdpsgzY3QVeY3oGtn2DyaXu4D38fYbuRHz7g9T_Ezfny9afdzE9Cx7pR
CitedBy_id	crossref_primary_10_1038_s41401_024_01423_4 crossref_primary_10_3389_fncel_2020_615125 crossref_primary_10_1016_j_snb_2024_135441 crossref_primary_10_3390_antiox10060848 crossref_primary_10_1038_s41374_020_0436_1 crossref_primary_10_1111_febs_16739 crossref_primary_10_1016_j_bbamcr_2024_119895 crossref_primary_10_1016_j_molimm_2021_04_023 crossref_primary_10_3390_nu12113245 crossref_primary_10_1007_s11756_021_00769_y crossref_primary_10_1007_s00109_020_02017_3 crossref_primary_10_1016_j_ijbiomac_2020_06_115 crossref_primary_10_1096_fj_202001393R crossref_primary_10_1111_febs_16774 crossref_primary_10_3390_cells9040931 crossref_primary_10_1007_s11010_018_3454_1 crossref_primary_10_3389_fnins_2022_947295 crossref_primary_10_3390_life12050638 crossref_primary_10_1167_iovs_18_24987 crossref_primary_10_7717_peerj_8638 crossref_primary_10_1016_j_chembiol_2020_08_012 crossref_primary_10_1093_jn_nxz155 crossref_primary_10_1186_s10020_023_00706_6 crossref_primary_10_1186_s40659_024_00511_3 crossref_primary_10_1038_s41420_024_02022_2 crossref_primary_10_1080_09273948_2022_2027464 crossref_primary_10_1096_fj_202402642R crossref_primary_10_1242_dmm_049119 crossref_primary_10_1016_j_biochi_2019_08_007 crossref_primary_10_1016_j_preteyeres_2020_100915 crossref_primary_10_1096_fj_202501459R crossref_primary_10_1016_j_theriogenology_2022_06_010 crossref_primary_10_1002_jnr_24543 crossref_primary_10_1155_2018_4374087 crossref_primary_10_3390_ijerph20064766 crossref_primary_10_1038_s41467_023_39775_w crossref_primary_10_3390_antiox11061086 crossref_primary_10_1111_febs_14740 crossref_primary_10_1097_IJG_0000000000001593 crossref_primary_10_3390_cimb46040204 crossref_primary_10_1016_j_lfs_2020_117654 crossref_primary_10_1097_ICO_0000000000003292 crossref_primary_10_3390_ijms26178598 crossref_primary_10_3390_antiox12061228 crossref_primary_10_1038_s41580_024_00794_0 crossref_primary_10_3390_biom12111693 crossref_primary_10_1002_alz_70497 crossref_primary_10_3390_ijms232112983 crossref_primary_10_3390_antiox12071465 crossref_primary_10_1167_iovs_66_9_70 crossref_primary_10_1002_jcp_28488 crossref_primary_10_1038_s41467_025_62775_x crossref_primary_10_1038_s41433_021_01562_6 crossref_primary_10_3389_fneur_2022_964197 crossref_primary_10_3390_antiox9040347 crossref_primary_10_3390_ijms25094789 crossref_primary_10_3390_jcm11144171 crossref_primary_10_1016_j_bbagen_2025_130814 crossref_primary_10_1097_ALN_0000000000003078 crossref_primary_10_1128_JVI_00887_19 crossref_primary_10_3390_cells10050996 crossref_primary_10_1016_j_ecoenv_2021_112299 crossref_primary_10_3390_ijms23020649 crossref_primary_10_3390_ph16091193 crossref_primary_10_1007_s00726_022_03199_5 crossref_primary_10_3390_cells10050995 crossref_primary_10_1186_s13024_022_00528_w crossref_primary_10_26508_lsa_201900340 crossref_primary_10_1186_s12951_025_03245_w crossref_primary_10_1073_pnas_2322582121 crossref_primary_10_1167_iovs_18_24890 crossref_primary_10_3390_ijms20020409 crossref_primary_10_1038_s41467_020_19352_1 crossref_primary_10_1016_j_jds_2022_02_006 crossref_primary_10_1080_02713683_2020_1867748 crossref_primary_10_1016_j_tips_2019_07_003 crossref_primary_10_1242_bio_052332 crossref_primary_10_3389_fcell_2021_631413 crossref_primary_10_1016_j_freeradbiomed_2021_07_031 crossref_primary_10_3390_ijms25147826 crossref_primary_10_3390_ijms25021120 crossref_primary_10_3390_ijms26051858 crossref_primary_10_1097_ICU_0000000000000747 crossref_primary_10_1016_j_fsi_2025_110423
Cites_doi	10.1111/j.1471-4159.2007.04573.x 10.1258/ebm.2011.010400 10.1155/2012/589589 10.1038/ncb0311-184 10.1038/380439a0 10.1128/MCB.00408-06 10.1038/nature16932 10.1016/j.biocel.2009.10.006 10.1371/journal.pone.0009575 10.1016/j.molcel.2009.08.021 10.1016/j.devcel.2007.07.018 10.1097/00055735-199712000-00003 10.1038/nrm3823 10.1016/j.conb.2004.04.002 10.1097/IAE.0b013e3181c70168 10.1126/scisignal.aan5785 10.1016/j.exer.2011.08.005 10.1167/iovs.15-16969 10.1523/JNEUROSCI.14-07-04368.1994 10.1007/s12035-014-8881-8 10.1126/science.275.5300.668 10.2337/db11-0315 10.1073/pnas.94.7.3128 10.1167/iovs.12-10221 10.1016/j.febslet.2009.04.007 10.1111/j.1471-4159.2005.03502.x 10.1167/iovs.11-9235 10.18632/aging.100556 10.1016/j.exer.2010.04.002 10.1016/j.cmet.2013.02.003 10.1038/ejhg.2017.131 10.1128/MCB.25.3.921-932.2005 10.1046/j.1471-4159.2003.02141.x 10.1038/16729 10.1146/annurev-cellbio-092910-154002 10.1073/pnas.252341799 10.1172/JCI58183 10.1038/nm.4000 10.1016/j.cell.2013.10.019 10.1155/2012/507986 10.1016/j.ajpath.2015.03.009 10.1007/s00125-012-2594-1 10.1136/bjo.2005.081224 10.1016/j.devcel.2014.11.012 10.1038/nature10600 10.1126/science.1209038 10.1038/sj.cdd.4401365 10.1172/JCI69774 10.1001/archophthalmol.2011.267 10.1007/978-1-4614-0631-0_37 10.1155/2012/743780 10.1101/cshperspect.a013177 10.1016/j.bbrc.2004.07.118 10.1091/mbc.e07-03-0272 10.1371/journal.pone.0083871 10.1016/j.preteyeres.2008.05.001 10.1016/j.cell.2013.10.041 10.1016/j.neulet.2011.06.057 10.1006/exnr.2000.7573 10.1083/jcb.200706181 10.1056/NEJM199304153281507 10.1016/S0092-8674(00)81360-4 10.1155/2014/160140 10.1038/sj.jcbfm.9600005 10.1016/S1534-5807(02)00210-1 10.1001/archopht.1997.01100160201010 10.1016/S1534-5807(02)00203-4 10.1371/journal.pone.0033266 10.1146/annurev.genom.6.080604.162209 10.1016/0002-9394(84)90636-6 10.1126/scitranslmed.aaf9440 10.1073/pnas.1606387114 10.1128/MCB.23.21.7448-7459.2003 10.1371/journal.pgen.0010004 10.1091/mbc.10.11.3787 10.1016/j.brainres.2016.04.021 10.1038/nrm2233 10.1016/S0039-6257(02)00353-3 10.1016/S0006-291X(03)00353-X 10.1016/S0092-8674(01)00611-0 10.1684/ecn.2009.0170 10.1523/JNEUROSCI.17-11-04212.1997 10.1073/pnas.0910342106 10.1073/pnas.0911991107 10.1371/journal.pone.0154779 10.1136/bjo.80.5.389 10.1016/j.neuron.2011.11.026 10.1016/S0092-8674(00)80369-4 10.1167/iovs.14-16220 10.1038/ng.3319 10.1101/cshperspect.a013169 10.1016/j.devcel.2007.07.005 10.1056/NEJMra0804630 10.1007/978-3-319-17121-0_25 10.1007/s00125-012-2692-0 10.1038/nature02656 10.1038/ncb2738 10.1007/978-1-4614-0631-0_100 10.1016/S0140-6736(04)16257-0 10.1016/j.celrep.2013.03.024 10.1371/journal.pone.0151806 10.1074/jbc.M110636200 10.1038/415092a 10.1371/journal.pone.0063205
ContentType	Journal Article
Copyright	Published 2018. This article is a U.S. Government work and is in the public domain in the USA. Copyright © 2019 Federation of European Biochemical Societies
Copyright_xml	– notice: Published 2018. This article is a U.S. Government work and is in the public domain in the USA. – notice: Copyright © 2019 Federation of European Biochemical Societies
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7TK 7TM 7U9 8FD C1K FR3 H94 M7N P64 RC3 7X8 7S9 L.6 5PM
DOI	10.1111/febs.14522
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Virology and AIDS Abstracts Technology Research Database Nucleic Acids Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management Genetics Abstracts Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Chemoreception Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts MEDLINE - Academic AGRICOLA AGRICOLA - Academic
DatabaseTitleList	Virology and AIDS Abstracts AGRICOLA MEDLINE - Academic MEDLINE CrossRef
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Anatomy & Physiology Chemistry
EISSN	1742-4658
EndPage	412
ExternalDocumentID	PMC6583901 29802807 10_1111_febs_14522 FEBS14522
Genre	reviewArticle Journal Article Review
GrantInformation_xml	– fundername: NEI NIH HHS grantid: R01 EY027335 – fundername: BLRD VA grantid: I01 BX002284 – fundername: NINDS NIH HHS grantid: R01 NS088485 – fundername: RRD VA grantid: I01 RX002340
GroupedDBID	--- -DZ -~X .3N .55 .GA .Y3 05W 0R~ 10A 1OC 24P 29H 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 A8Z AAESR AAEVG AAHBH AAHHS AAHQN AAIPD AAMNL AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABDBF ABEFU ABEML ABPVW ABQWH ABXGK ACAHQ ACCFJ ACCZN ACFBH ACGFS ACGOF ACIWK ACMXC ACNCT ACPOU ACPRK ACSCC ACUHS ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFRAH AFWVQ AFZJQ AHBTC AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ATUGU AZBYB AZVAB BAFTC BAWUL BFHJK BHBCM BMXJE BROTX BRXPI BY8 C1A C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM E3Z EAD EAP EAS EAU EBB EBC EBD EBS EBX EJD EMB EMK EMOBN EST ESX EX3 F00 F01 F04 F5P FIJ FUBAC G-S G.N GODZA GX1 H.X HF~ HGLYW HH5 HZI HZ~ IHE IX1 J0M KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MVM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OBS OIG OK1 OVD P2W P2X P2Z P4B P4D PQQKQ Q.N Q11 QB0 R.K RNS ROL RX1 SUPJJ SV3 TEORI TR2 TUS UB1 V8K W8V W99 WBFHL WBKPD WIH WIJ WIK WIN WOHZO WOQ WOW WQJ WRC WXI WXSBR WYISQ X7M XG1 Y6R ~IA ~KM ~WT AAMMB AAYXX AEFGJ AEYWJ AGHNM AGXDD AGYGG AIDQK AIDYY CITATION O8X CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7TK 7TM 7U9 8FD C1K FR3 H94 M7N P64 RC3 7X8 ESTFP 7S9 L.6 5PM
ID	FETCH-LOGICAL-c5472-b691f5726dbf1fc83989a92010b2b7a6a09cbaa6ba1f9ac9a70666e4e7f3fa8a3
IEDL.DBID	WIN
ISICitedReferencesCount	91
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000456553900011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1742-464X 1742-4658
IngestDate	Tue Sep 30 16:29:10 EDT 2025 Fri Sep 05 17:23:19 EDT 2025 Mon Sep 29 02:01:17 EDT 2025 Fri Jul 25 19:35:34 EDT 2025 Thu Apr 03 07:05:02 EDT 2025 Sat Nov 29 04:35:51 EST 2025 Tue Nov 18 21:05:29 EST 2025 Wed Jan 22 16:22:17 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	2
Keywords	retinal degeneration RPE UPR VEGF glaucoma AMD ER stress achromatopsia neurodegernation RGC
Language	English
License	Published 2018. This article is a U.S. Government work and is in the public domain in the USA.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c5472-b691f5726dbf1fc83989a92010b2b7a6a09cbaa6ba1f9ac9a70666e4e7f3fa8a3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
OpenAccessLink	https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.14522
PMID	29802807
PQID	2170574141
PQPubID	28478
PageCount	14
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_6583901 proquest_miscellaneous_2221060431 proquest_miscellaneous_2045281119 proquest_journals_2170574141 pubmed_primary_29802807 crossref_primary_10_1111_febs_14522 crossref_citationtrail_10_1111_febs_14522 wiley_primary_10_1111_febs_14522_FEBS14522
PublicationCentury	2000
PublicationDate	January 2019
PublicationDateYYYYMMDD	2019-01-01
PublicationDate_xml	– month: 01 year: 2019 text: January 2019
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England – name: Oxford
PublicationTitle	The FEBS journal
PublicationTitleAlternate	FEBS J
PublicationYear	2019
Publisher	Blackwell Publishing Ltd
Publisher_xml	– name: Blackwell Publishing Ltd
References	2011; 479 2011; 236 2007; 102 2013; 3 2004; 322 2010; 107 1995; 36 1997; 275 2002; 277 2002; 99 1996; 380 2013; 8 2013; 5 2001; 42 1997; 8 2007; 179 2011; 129 2008; 27 1980; 32 2007; 8 2014; 15 2009; 360 2010; 5 2010; 30 2011; 121 2014; 124 2007; 18 2015; 56 2001; 167 2015; 52 2002; 415 2002; 3 2014; 2014 2007; 13 2004; 429 2016; 11 2010; 42 2011; 93 2009; 583 1994; 14 2005; 6 2016; 854 2005; 1 1996; 80 2018; 11 1996; 87 2016; 8 2003; 23 2009; 106 2016; 22 2014; 31 2012; 61 2015; 185 1997; 115 2004; 363 2009; 41 2012; 2012 1993; 328 2000; 41 2016; 1648 2011; 13 2001; 107 2012; 55 2017; 114 2012; 723 2012; 53 2005; 25 1997; 90 2002; 47 1984; 97 2015; 47 2013; 15 1997; 94 2013; 17 2002; 43 2013; 155 1997; 17 1999; 10 2014; 9 2011; 27 2007; 27 2004; 88 2011; 334 2006; 90 2006; 96 2009; 20 2017; 25 2008; 14 2012; 73 2011; 501 2004; 11 2009; 35 2003; 303 2004; 14 2015; 21 2016; 530 1999; 397 2012; 7 2010; 91 2012; 4 e_1_2_11_93_1 e_1_2_11_78_1 e_1_2_11_36_1 e_1_2_11_51_1 e_1_2_11_74_1 e_1_2_11_97_1 e_1_2_11_13_1 e_1_2_11_29_1 e_1_2_11_4_1 e_1_2_11_106_1 e_1_2_11_48_1 e_1_2_11_81_1 Shimazawa M (e_1_2_11_70_1) 2007; 13 e_1_2_11_20_1 e_1_2_11_66_1 e_1_2_11_47_1 e_1_2_11_89_1 e_1_2_11_24_1 e_1_2_11_62_1 e_1_2_11_8_1 e_1_2_11_43_1 e_1_2_11_85_1 e_1_2_11_17_1 e_1_2_11_113_1 e_1_2_11_50_1 e_1_2_11_92_1 e_1_2_11_31_1 e_1_2_11_77_1 e_1_2_11_58_1 e_1_2_11_35_1 e_1_2_11_73_1 e_1_2_11_12_1 e_1_2_11_54_1 e_1_2_11_96_1 e_1_2_11_103_1 e_1_2_11_28_1 e_1_2_11_5_1 e_1_2_11_61_1 e_1_2_11_80_1 Quigley HA (e_1_2_11_102_1) 1995; 36 e_1_2_11_46_1 e_1_2_11_69_1 e_1_2_11_88_1 e_1_2_11_107_1 e_1_2_11_9_1 e_1_2_11_23_1 e_1_2_11_42_1 e_1_2_11_65_1 e_1_2_11_84_1 e_1_2_11_114_1 e_1_2_11_16_1 e_1_2_11_110_1 e_1_2_11_39_1 Li B (e_1_2_11_26_1) 2008; 14 e_1_2_11_72_1 e_1_2_11_91_1 e_1_2_11_30_1 e_1_2_11_57_1 e_1_2_11_99_1 e_1_2_11_53_1 e_1_2_11_76_1 e_1_2_11_95_1 e_1_2_11_11_1 e_1_2_11_6_1 e_1_2_11_104_1 e_1_2_11_27_1 e_1_2_11_2_1 e_1_2_11_100_1 e_1_2_11_83_1 e_1_2_11_60_1 Swiderski RE (e_1_2_11_55_1) 2000; 41 e_1_2_11_45_1 e_1_2_11_68_1 Abcouwer SF (e_1_2_11_34_1) 2002; 43 e_1_2_11_41_1 e_1_2_11_87_1 e_1_2_11_108_1 e_1_2_11_22_1 e_1_2_11_64_1 e_1_2_11_15_1 e_1_2_11_111_1 e_1_2_11_38_1 e_1_2_11_19_1 Hagstrom SA (e_1_2_11_59_1) 2001; 42 e_1_2_11_94_1 e_1_2_11_71_1 e_1_2_11_90_1 e_1_2_11_10_1 Kant S (e_1_2_11_32_1) 2009; 41 Boughman JA (e_1_2_11_56_1) 1980; 32 e_1_2_11_79_1 e_1_2_11_14_1 e_1_2_11_52_1 e_1_2_11_98_1 e_1_2_11_33_1 e_1_2_11_75_1 e_1_2_11_7_1 e_1_2_11_105_1 e_1_2_11_3_1 e_1_2_11_49_1 e_1_2_11_101_1 Ullah I (e_1_2_11_63_1) 2016; 22 e_1_2_11_82_1 e_1_2_11_21_1 e_1_2_11_44_1 e_1_2_11_67_1 e_1_2_11_25_1 e_1_2_11_40_1 e_1_2_11_86_1 e_1_2_11_109_1 e_1_2_11_18_1 e_1_2_11_37_1 e_1_2_11_112_1
References_xml	– volume: 47 start-page: 547 year: 2002 end-page: 561 article-title: Myocilin glaucoma publication-title: Surv Ophthalmol – volume: 501 start-page: 102 year: 2011 end-page: 106 article-title: Effect of neurotrophin‐4 on endoplasmic reticulum stress‐related neuronal apoptosis in diabetic and high glucose exposed rat retinas publication-title: Neurosci Lett – volume: 56 start-page: 6961 year: 2015 end-page: 6970 article-title: In vivo visualization of endoplasmic reticulum stress in the retina using the ERAI reporter mouse publication-title: Invest Ophthalmol Vis Sci – volume: 530 start-page: 184 year: 2016 end-page: 189 article-title: Naturally occurring p16(Ink4a)‐positive cells shorten healthy lifespan publication-title: Nature – volume: 11 start-page: e0154779 year: 2016 article-title: Limited ATF4 expression in degenerating retinas with ongoing ER stress promotes photoreceptor survival in a mouse model of autosomal dominant retinitis pigmentosa publication-title: PLoS ONE – volume: 91 start-page: 48 year: 2010 end-page: 53 article-title: Mechanisms of retinal ganglion cell injury and defense in glaucoma publication-title: Exp Eye Res – volume: 13 start-page: 365 year: 2007 end-page: 376 article-title: Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1 publication-title: Dev Cell – volume: 2012 start-page: 589589 year: 2012 article-title: ER stress and apoptosis: a new mechanism for retinal cell death publication-title: Exp Diabet Res – volume: 22 start-page: 797 year: 2016 end-page: 815 article-title: Pathogenic mutations in TULP1 responsible for retinitis pigmentosa identified in consanguineous familial cases publication-title: Mol Vis – volume: 107 start-page: 5961 year: 2010 end-page: 5966 article-title: Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78 publication-title: Proc Natl Acad Sci USA – volume: 11 start-page: eaan5785 year: 2018 article-title: The unfolded protein response regulator ATF6 promotes mesodermal differentiation publication-title: Sci Signal – volume: 6 start-page: 15 year: 2005 end-page: 44 article-title: Complex genetics of glaucoma susceptibility publication-title: Annu Rev Genomics Hum Genet – volume: 328 start-page: 1097 year: 1993 end-page: 1106 article-title: Open‐angle glaucoma publication-title: N Engl J Med – volume: 583 start-page: 1521 year: 2009 end-page: 1527 article-title: Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy publication-title: FEBS Lett – volume: 167 start-page: 282 year: 2001 end-page: 289 article-title: Retinal ganglion cell and nonneuronal cell responses to a microcrush lesion of adult rat optic nerve publication-title: Exp Neurol – volume: 41 start-page: 170 year: 2009 end-page: 173 article-title: Vascular endothelial growth factor‐A (VEGF‐A) in vitreous fluid of patients with proliferative diabetic retinopathy publication-title: Ann Ophthalmol – volume: 90 start-page: 1031 year: 1997 end-page: 1039 article-title: The transmembrane kinase Ire1p is a site‐specific endonuclease that initiates mRNA splicing in the unfolded protein response publication-title: Cell – volume: 102 start-page: 922 year: 2007 end-page: 930 article-title: A critical role for Bim in retinal ganglion cell death publication-title: J Neurochem – volume: 3 start-page: 99 year: 2002 end-page: 111 article-title: ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals publication-title: Develop Cell – volume: 56 start-page: 3860 year: 2015 end-page: 3868 article-title: Increased endoplasmic reticulum stress in human glaucomatous trabecular meshwork cells and tissues publication-title: Invest Ophthalmol Vis Sci – volume: 53 start-page: 7590 year: 2012 end-page: 7599 article-title: Induction of endoplasmic reticulum stress genes, BiP and Chop, in genetic and environmental models of retinal degeneration publication-title: Invest Ophthalmol Vis Sci – volume: 2012 start-page: 507986 year: 2012 article-title: Endoplasmic reticulum stress‐related factors protect against diabetic retinopathy publication-title: Exp Diabet Res – volume: 21 start-page: 1424 year: 2015 end-page: 1435 article-title: Cellular senescence in aging and age‐related disease: from mechanisms to therapy publication-title: Nat Med – volume: 14 start-page: 1122 year: 2008 end-page: 1128 article-title: P58(IPK) inhibition of endoplasmic reticulum stress in human retinal capillary endothelial cells in vitro publication-title: Mol Vis – volume: 80 start-page: 389 year: 1996 end-page: 393 article-title: Number of people with glaucoma worldwide publication-title: Br J Ophthalmol – volume: 17 start-page: 4212 year: 1997 end-page: 4222 article-title: Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta‐peptide: involvement of calcium and oxyradicals publication-title: J Neurosci – volume: 31 start-page: 722 year: 2014 end-page: 733 article-title: An essential role for senescent cells in optimal wound healing through secretion of PDGF‐AA publication-title: Dev Cell – volume: 11 start-page: 403 year: 2004 end-page: 415 article-title: Ischemia‐induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP publication-title: Cell Death Differ – volume: 303 start-page: 496 year: 2003 end-page: 503 article-title: Mutant SOD1 linked to familial amyotrophic lateral sclerosis, but not wild‐type SOD1, induces ER stress in COS7 cells and transgenic mice publication-title: Biochem Biophys Res Comm – volume: 107 start-page: 881 year: 2001 end-page: 891 article-title: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor publication-title: Cell – volume: 2012 start-page: 743780 year: 2012 article-title: Expression of endoplasmic reticulum stress‐related factors in the retinas of diabetic rats publication-title: Exp Diabet Res – volume: 7 start-page: e33266 year: 2012 article-title: ER stress in retinal degeneration in S334ter rho rats publication-title: PLoS ONE – volume: 5 start-page: a013169 year: 2013 article-title: Endoplasmic reticulum stress sensing in the unfolded protein response publication-title: Cold Spring Harb Perspect Biol – volume: 2014 start-page: 160140 year: 2014 article-title: The unfolded protein response and diabetic retinopathy publication-title: J Diabetes Res – volume: 5 start-page: 330 year: 2013 end-page: 331 article-title: Metformin, aging and cancer publication-title: Aging – volume: 10 start-page: 3787 year: 1999 end-page: 3799 article-title: Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress publication-title: Mol Biol Cell – volume: 30 start-page: 761 year: 2010 end-page: 764 article-title: Dose of intravitreal bevacizumab (Avastin) used as preoperative adjunct therapy for proliferative diabetic retinopathy publication-title: Retina – volume: 61 start-page: 492 year: 2012 end-page: 504 article-title: Activation of endoplasmic reticulum stress by hyperglycemia is essential for Muller cell‐derived inflammatory cytokine production in diabetes publication-title: Diabetes – volume: 52 start-page: 679 year: 2015 end-page: 695 article-title: Robust endoplasmic reticulum‐associated degradation of rhodopsin precedes retinal degeneration publication-title: Mol Neurobiol – volume: 179 start-page: 1523 year: 2007 end-page: 1537 article-title: Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma publication-title: J Cell Biol – volume: 42 start-page: 1955 year: 2001 end-page: 1962 article-title: A role for the Tubby‐like protein 1 in rhodopsin transport publication-title: Invest Ophthalmol Vis Sci – volume: 155 start-page: 1119 year: 2013 end-page: 1130 article-title: Senescence is a developmental mechanism that contributes to embryonic growth and patterning publication-title: Cell – volume: 41 start-page: 3420 year: 2000 end-page: 3428 article-title: Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization publication-title: Invest Ophthalmol Vis Sci – volume: 3 start-page: 1 year: 2002 end-page: 2 article-title: BiP binding keeps ATF6 at bay publication-title: Develop Cell – volume: 13 start-page: 184 year: 2011 end-page: 190 article-title: Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress publication-title: Nat Cell Biol – volume: 275 start-page: 668 year: 1997 end-page: 670 article-title: Identification of a gene that causes primary open angle glaucoma publication-title: Science – volume: 8 start-page: e63205 year: 2013 article-title: Ablation of C/EBP homologous protein does not protect T17M RHO mice from retinal degeneration publication-title: PLoS ONE – volume: 854 start-page: 185 year: 2016 end-page: 191 article-title: Ablation of Chop transiently enhances photoreceptor survival but does not prevent retinal degeneration in transgenic mice expressing human P23H rhodopsin publication-title: Adv Exp Med Biol – volume: 114 start-page: 400 year: 2017 end-page: 405 article-title: Achromatopsia mutations target sequential steps of ATF6 activation publication-title: Proc Natl Acad Sci USA – volume: 25 start-page: 41 year: 2005 end-page: 53 article-title: Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxidative stress in ischemic neurons publication-title: J Cereb Blood Flow Metab – volume: 15 start-page: 481 year: 2013 end-page: 490 article-title: ER‐stress‐induced transcriptional regulation increases protein synthesis leading to cell death publication-title: Nat Cell Biol – volume: 20 start-page: 158 year: 2009 end-page: 163 article-title: VEGF‐A: a critical regulator of blood vessel growth publication-title: Europ Cytokine Net – volume: 1648 start-page: 538 year: 2016 end-page: 541 article-title: Endoplasmic reticulum stress in human photoreceptor diseases publication-title: Brain Res – volume: 27 start-page: 331 year: 2008 end-page: 371 article-title: Vascular endothelial growth factor in eye disease publication-title: Prog Retin Eye Res – volume: 55 start-page: 3128 year: 2012 end-page: 3140 article-title: Mechanisms of modified LDL‐induced pericyte loss and retinal injury in diabetic retinopathy publication-title: Diabetologia – volume: 155 start-page: 1104 year: 2013 end-page: 1118 article-title: Programmed cell senescence during mammalian embryonic development publication-title: Cell – volume: 17 start-page: 353 year: 2013 end-page: 371 article-title: Neuronal ER stress impedes myeloid‐cell‐induced vascular regeneration through IRE1alpha degradation of netrin‐1 publication-title: Cell Metab – volume: 14 start-page: 384 year: 2004 end-page: 389 article-title: How do Parkin mutations result in neurodegeneration? publication-title: Curr Opin Neurobiol – volume: 93 start-page: 658 year: 2011 end-page: 668 article-title: Immunocytochemical evidence of Tulp1‐dependent outer segment protein transport pathways in photoreceptor cells publication-title: Exp Eye Res – volume: 11 start-page: e0151806 year: 2016 article-title: Involvement of endoplasmic reticulum stress in TULP1 induced retinal degeneration publication-title: PLoS ONE – volume: 124 start-page: 1956 year: 2014 end-page: 1965 article-title: Ocular‐specific ER stress reduction rescues glaucoma in murine glucocorticoid‐induced glaucoma publication-title: J Clin Invest – volume: 94 start-page: 3128 year: 1997 end-page: 3133 article-title: Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases publication-title: Proc Natl Acad Sci USA – volume: 9 start-page: e83871 year: 2014 article-title: Ablation of the proapoptotic genes chop or Ask1 does not prevent or delay loss of visual function in a P23H transgenic mouse model of retinitis pigmentosa publication-title: PLoS ONE – volume: 415 start-page: 92 year: 2002 end-page: 96 article-title: IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP‐1 mRNA publication-title: Nature – volume: 42 start-page: 5 year: 2010 end-page: 12 article-title: Proliferative retinopathies: angiogenesis that blinds publication-title: Int J Biochem Cell Biol – volume: 185 start-page: 1800 year: 2015 end-page: 1808 article-title: Multiple mechanisms of unfolded protein response‐induced cell death publication-title: Am J Pathol – volume: 322 start-page: 281 year: 2004 end-page: 286 article-title: Caspase‐12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS publication-title: Biochem Biophys Res Comm – volume: 129 start-page: 1351 year: 2011 end-page: 1357 article-title: Association of pathogenic mutations in TULP1 with retinitis pigmentosa in consanguineous Pakistani families publication-title: Arch Ophthalmol – volume: 73 start-page: 445 year: 2012 end-page: 452 article-title: Differential effects of unfolded protein response pathways on axon injury‐induced death of retinal ganglion cells publication-title: Neuron – volume: 397 start-page: 271 year: 1999 end-page: 274 article-title: Protein translation and folding are coupled by an endoplasmic‐reticulum‐resident kinase publication-title: Nature – volume: 25 start-page: 1210 year: 2017 end-page: 1216 article-title: Autosomal recessive cone‐rod dystrophy can be caused by mutations in the ATF6 gene publication-title: Eur J Hum Genet – volume: 121 start-page: 3542 year: 2011 end-page: 3553 article-title: Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma publication-title: J Clin Invest – volume: 13 start-page: 351 year: 2007 end-page: 364 article-title: ATF6alpha optimizes long‐term endoplasmic reticulum function to protect cells from chronic stress publication-title: Dev Cell – volume: 99 start-page: 15920 year: 2002 end-page: 15925 article-title: Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress‐induced molecular chaperone P58IPK publication-title: Proc Natl Acad Sci USA – volume: 106 start-page: 17775 year: 2009 end-page: 17780 article-title: In vitro reconstitution of ER‐stress induced ATF6 transport in COPII vesicles publication-title: Proc Natl Acad Sci USA – volume: 35 start-page: 551 year: 2009 end-page: 561 article-title: Fine‐tuning of the unfolded protein response: assembling the IRE1alpha interactome publication-title: Mol Cell – volume: 723 start-page: 285 year: 2012 end-page: 292 article-title: Intermittent but not constant high glucose induces ER stress and inflammation in human retinal pericytes publication-title: Adv Exp Med Biol – volume: 236 start-page: 1051 year: 2011 end-page: 1063 article-title: Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes publication-title: Exp Biol Med – volume: 88 start-page: 78 year: 2004 end-page: 90 article-title: Increased expression and processing of caspase‐12 after traumatic brain injury in rats publication-title: J Neurochem – volume: 25 start-page: 921 year: 2005 end-page: 932 article-title: Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response publication-title: Mol Cell Biol – volume: 23 start-page: 7448 year: 2003 end-page: 7459 article-title: XBP‐1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response publication-title: Mol Cell Biol – volume: 115 start-page: 1031 year: 1997 end-page: 1035 article-title: TUNEL‐positive ganglion cells in human primary open‐angle glaucoma publication-title: Arch Ophthalmol – volume: 14 start-page: 4368 year: 1994 end-page: 4374 article-title: Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats publication-title: J Neurosci – volume: 1 start-page: 17 year: 2005 end-page: 26 article-title: Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage publication-title: PLoS Genet – volume: 15 start-page: 482 year: 2014 end-page: 496 article-title: Cellular senescence: from physiology to pathology publication-title: Nat Rev Mol Cell Biol – volume: 18 start-page: 3681 year: 2007 end-page: 3691 article-title: The role of p58IPK in protecting the stressed endoplasmic reticulum publication-title: Mol Biol Cell – volume: 97 start-page: 357 year: 1984 end-page: 365 article-title: Prevalence of retinitis pigmentosa in Maine publication-title: Am J Ophthalmol – volume: 429 start-page: 841 year: 2004 end-page: 847 article-title: A membrane protein complex mediates retro‐translocation from the ER lumen into the cytosol publication-title: Nature – volume: 90 start-page: 262 year: 2006 end-page: 267 article-title: The number of people with glaucoma worldwide in 2010 and 2020 publication-title: Br J Ophthalmol – volume: 8 year: 2016 article-title: Senescence‐associated secretory phenotype contributes to pathological angiogenesis in retinopathy publication-title: Sci Transl Med – volume: 3 start-page: 1279 year: 2013 end-page: 1292 article-title: Stress‐independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments publication-title: Cell Rep – volume: 380 start-page: 439 year: 1996 end-page: 442 article-title: Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene publication-title: Nature – volume: 53 start-page: 3792 year: 2012 end-page: 3800 article-title: ER stress is involved in T17M rhodopsin‐induced retinal degeneration publication-title: Invest Ophthalmol Vis Sci – volume: 4 start-page: a013177 year: 2012 article-title: Protein‐folding homeostasis in the endoplasmic reticulum and nutritional regulation publication-title: Cold Spring Harb Perspect Biol – volume: 360 start-page: 1113 year: 2009 end-page: 1124 article-title: Primary open‐angle glaucoma publication-title: N Engl J Med – volume: 27 start-page: 563 year: 2011 end-page: 584 article-title: Developmental and pathological angiogenesis publication-title: Ann Rev Cell Develop Biol – volume: 479 start-page: 232 year: 2011 end-page: 236 article-title: Clearance of p16Ink4a‐positive senescent cells delays ageing‐associated disorders publication-title: Nature – volume: 334 start-page: 1081 year: 2011 end-page: 1086 article-title: The unfolded protein response: from stress pathway to homeostatic regulation publication-title: Science – volume: 277 start-page: 13045 year: 2002 end-page: 13052 article-title: The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi publication-title: J Biol Chem – volume: 5 start-page: e9575 year: 2010 article-title: Transcriptional regulation of VEGF‐A by the unfolded protein response pathway publication-title: PLoS ONE – volume: 27 start-page: 1027 year: 2007 end-page: 1043 article-title: Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress publication-title: Mol Cell Biol – volume: 36 start-page: 774 year: 1995 end-page: 786 article-title: Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis publication-title: Invest Ophthalmol Vis Sci – volume: 47 start-page: 757 year: 2015 end-page: 765 article-title: Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia publication-title: Nat Genet – volume: 55 start-page: 2533 year: 2012 end-page: 2545 article-title: Activating transcription factor 4 mediates hyperglycaemia‐induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes publication-title: Diabetologia – volume: 96 start-page: 43 year: 2006 end-page: 52 article-title: NMDA‐induced retinal injury is mediated by an endoplasmic reticulum stress‐related protein, CHOP/GADD153 publication-title: J Neurochem – volume: 32 start-page: 223 year: 1980 end-page: 235 article-title: Population genetic studies of retinitis pigmentosa publication-title: Am J Hum Genet – volume: 87 start-page: 391 year: 1996 end-page: 404 article-title: A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response publication-title: Cell – volume: 13 start-page: 578 year: 2007 end-page: 587 article-title: Involvement of ER stress in retinal cell death publication-title: Mol Vis – volume: 363 start-page: 1711 year: 2004 end-page: 1720 article-title: Primary open‐angle glaucoma publication-title: Lancet – volume: 43 start-page: 2791 year: 2002 end-page: 2798 article-title: Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress publication-title: Invest Ophthalmol Vis Sci – volume: 8 start-page: 729 year: 2007 end-page: 740 article-title: Cellular senescence: when bad things happen to good cells publication-title: Nat Rev Mol Cell Biol – volume: 723 start-page: 783 year: 2012 end-page: 789 article-title: Tulp1 is involved in specific photoreceptor protein transport pathways publication-title: Adv Exp Med Biol – volume: 8 start-page: 9 year: 1997 end-page: 15 article-title: Mechanisms of optic neuropathy publication-title: Curr Opin Ophthalmol – ident: e_1_2_11_96_1 doi: 10.1111/j.1471-4159.2007.04573.x – ident: e_1_2_11_40_1 doi: 10.1258/ebm.2011.010400 – ident: e_1_2_11_44_1 doi: 10.1155/2012/589589 – ident: e_1_2_11_18_1 doi: 10.1038/ncb0311-184 – ident: e_1_2_11_29_1 doi: 10.1038/380439a0 – ident: e_1_2_11_19_1 doi: 10.1128/MCB.00408-06 – ident: e_1_2_11_82_1 doi: 10.1038/nature16932 – ident: e_1_2_11_89_1 doi: 10.1016/j.biocel.2009.10.006 – ident: e_1_2_11_33_1 doi: 10.1371/journal.pone.0009575 – ident: e_1_2_11_9_1 doi: 10.1016/j.molcel.2009.08.021 – ident: e_1_2_11_81_1 doi: 10.1016/j.devcel.2007.07.018 – ident: e_1_2_11_94_1 doi: 10.1097/00055735-199712000-00003 – ident: e_1_2_11_87_1 doi: 10.1038/nrm3823 – ident: e_1_2_11_109_1 doi: 10.1016/j.conb.2004.04.002 – ident: e_1_2_11_31_1 doi: 10.1097/IAE.0b013e3181c70168 – ident: e_1_2_11_114_1 doi: 10.1126/scisignal.aan5785 – ident: e_1_2_11_58_1 doi: 10.1016/j.exer.2011.08.005 – ident: e_1_2_11_66_1 doi: 10.1167/iovs.15-16969 – ident: e_1_2_11_95_1 doi: 10.1523/JNEUROSCI.14-07-04368.1994 – ident: e_1_2_11_65_1 doi: 10.1007/s12035-014-8881-8 – ident: e_1_2_11_54_1 doi: 10.1126/science.275.5300.668 – volume: 13 start-page: 578 year: 2007 ident: e_1_2_11_70_1 article-title: Involvement of ER stress in retinal cell death publication-title: Mol Vis – ident: e_1_2_11_42_1 doi: 10.2337/db11-0315 – ident: e_1_2_11_61_1 doi: 10.1073/pnas.94.7.3128 – ident: e_1_2_11_67_1 doi: 10.1167/iovs.12-10221 – ident: e_1_2_11_35_1 doi: 10.1016/j.febslet.2009.04.007 – ident: e_1_2_11_106_1 doi: 10.1111/j.1471-4159.2005.03502.x – ident: e_1_2_11_68_1 doi: 10.1167/iovs.11-9235 – ident: e_1_2_11_92_1 doi: 10.18632/aging.100556 – ident: e_1_2_11_104_1 doi: 10.1016/j.exer.2010.04.002 – ident: e_1_2_11_93_1 doi: 10.1016/j.cmet.2013.02.003 – ident: e_1_2_11_79_1 doi: 10.1038/ejhg.2017.131 – ident: e_1_2_11_6_1 doi: 10.1128/MCB.25.3.921-932.2005 – ident: e_1_2_11_110_1 doi: 10.1046/j.1471-4159.2003.02141.x – ident: e_1_2_11_15_1 doi: 10.1038/16729 – volume: 43 start-page: 2791 year: 2002 ident: e_1_2_11_34_1 article-title: Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress publication-title: Invest Ophthalmol Vis Sci – ident: e_1_2_11_27_1 doi: 10.1146/annurev-cellbio-092910-154002 – ident: e_1_2_11_24_1 doi: 10.1073/pnas.252341799 – ident: e_1_2_11_49_1 doi: 10.1172/JCI58183 – ident: e_1_2_11_84_1 doi: 10.1038/nm.4000 – ident: e_1_2_11_86_1 doi: 10.1016/j.cell.2013.10.019 – volume: 32 start-page: 223 year: 1980 ident: e_1_2_11_56_1 article-title: Population genetic studies of retinitis pigmentosa publication-title: Am J Hum Genet – ident: e_1_2_11_43_1 doi: 10.1155/2012/507986 – ident: e_1_2_11_2_1 doi: 10.1016/j.ajpath.2015.03.009 – ident: e_1_2_11_36_1 doi: 10.1007/s00125-012-2594-1 – ident: e_1_2_11_47_1 doi: 10.1136/bjo.2005.081224 – ident: e_1_2_11_85_1 doi: 10.1016/j.devcel.2014.11.012 – ident: e_1_2_11_83_1 doi: 10.1038/nature10600 – ident: e_1_2_11_3_1 doi: 10.1126/science.1209038 – ident: e_1_2_11_111_1 doi: 10.1038/sj.cdd.4401365 – ident: e_1_2_11_50_1 doi: 10.1172/JCI69774 – ident: e_1_2_11_62_1 doi: 10.1001/archophthalmol.2011.267 – ident: e_1_2_11_37_1 doi: 10.1007/978-1-4614-0631-0_37 – ident: e_1_2_11_41_1 doi: 10.1155/2012/743780 – ident: e_1_2_11_16_1 doi: 10.1101/cshperspect.a013177 – ident: e_1_2_11_113_1 doi: 10.1016/j.bbrc.2004.07.118 – ident: e_1_2_11_25_1 doi: 10.1091/mbc.e07-03-0272 – ident: e_1_2_11_75_1 doi: 10.1371/journal.pone.0083871 – ident: e_1_2_11_30_1 doi: 10.1016/j.preteyeres.2008.05.001 – ident: e_1_2_11_88_1 doi: 10.1016/j.cell.2013.10.041 – ident: e_1_2_11_39_1 doi: 10.1016/j.neulet.2011.06.057 – volume: 14 start-page: 1122 year: 2008 ident: e_1_2_11_26_1 article-title: P58(IPK) inhibition of endoplasmic reticulum stress in human retinal capillary endothelial cells in vitro publication-title: Mol Vis – ident: e_1_2_11_97_1 doi: 10.1006/exnr.2000.7573 – ident: e_1_2_11_98_1 doi: 10.1083/jcb.200706181 – ident: e_1_2_11_101_1 doi: 10.1056/NEJM199304153281507 – ident: e_1_2_11_8_1 doi: 10.1016/S0092-8674(00)81360-4 – volume: 41 start-page: 3420 year: 2000 ident: e_1_2_11_55_1 article-title: Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization publication-title: Invest Ophthalmol Vis Sci – ident: e_1_2_11_45_1 doi: 10.1155/2014/160140 – ident: e_1_2_11_108_1 doi: 10.1038/sj.jcbfm.9600005 – ident: e_1_2_11_7_1 doi: 10.1016/S1534-5807(02)00210-1 – ident: e_1_2_11_99_1 doi: 10.1001/archopht.1997.01100160201010 – ident: e_1_2_11_5_1 doi: 10.1016/S1534-5807(02)00203-4 – ident: e_1_2_11_69_1 doi: 10.1371/journal.pone.0033266 – ident: e_1_2_11_53_1 doi: 10.1146/annurev.genom.6.080604.162209 – ident: e_1_2_11_57_1 doi: 10.1016/0002-9394(84)90636-6 – volume: 41 start-page: 170 year: 2009 ident: e_1_2_11_32_1 article-title: Vascular endothelial growth factor‐A (VEGF‐A) in vitreous fluid of patients with proliferative diabetic retinopathy publication-title: Ann Ophthalmol – ident: e_1_2_11_90_1 doi: 10.1126/scitranslmed.aaf9440 – volume: 36 start-page: 774 year: 1995 ident: e_1_2_11_102_1 article-title: Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis publication-title: Invest Ophthalmol Vis Sci – ident: e_1_2_11_78_1 doi: 10.1073/pnas.1606387114 – ident: e_1_2_11_13_1 doi: 10.1128/MCB.23.21.7448-7459.2003 – ident: e_1_2_11_100_1 doi: 10.1371/journal.pgen.0010004 – ident: e_1_2_11_20_1 doi: 10.1091/mbc.10.11.3787 – ident: e_1_2_11_71_1 doi: 10.1016/j.brainres.2016.04.021 – ident: e_1_2_11_91_1 doi: 10.1038/nrm2233 – ident: e_1_2_11_52_1 doi: 10.1016/S0039-6257(02)00353-3 – ident: e_1_2_11_112_1 doi: 10.1016/S0006-291X(03)00353-X – ident: e_1_2_11_12_1 doi: 10.1016/S0092-8674(01)00611-0 – ident: e_1_2_11_28_1 doi: 10.1684/ecn.2009.0170 – ident: e_1_2_11_107_1 doi: 10.1523/JNEUROSCI.17-11-04212.1997 – ident: e_1_2_11_22_1 doi: 10.1073/pnas.0910342106 – ident: e_1_2_11_72_1 doi: 10.1073/pnas.0911991107 – ident: e_1_2_11_73_1 doi: 10.1371/journal.pone.0154779 – ident: e_1_2_11_46_1 doi: 10.1136/bjo.80.5.389 – ident: e_1_2_11_105_1 doi: 10.1016/j.neuron.2011.11.026 – volume: 42 start-page: 1955 year: 2001 ident: e_1_2_11_59_1 article-title: A role for the Tubby‐like protein 1 in rhodopsin transport publication-title: Invest Ophthalmol Vis Sci – ident: e_1_2_11_10_1 doi: 10.1016/S0092-8674(00)80369-4 – ident: e_1_2_11_51_1 doi: 10.1167/iovs.14-16220 – ident: e_1_2_11_77_1 doi: 10.1038/ng.3319 – ident: e_1_2_11_4_1 doi: 10.1101/cshperspect.a013169 – ident: e_1_2_11_80_1 doi: 10.1016/j.devcel.2007.07.005 – ident: e_1_2_11_48_1 doi: 10.1056/NEJMra0804630 – ident: e_1_2_11_76_1 doi: 10.1007/978-3-319-17121-0_25 – ident: e_1_2_11_38_1 doi: 10.1007/s00125-012-2692-0 – ident: e_1_2_11_23_1 doi: 10.1038/nature02656 – ident: e_1_2_11_17_1 doi: 10.1038/ncb2738 – ident: e_1_2_11_60_1 doi: 10.1007/978-1-4614-0631-0_100 – ident: e_1_2_11_103_1 doi: 10.1016/S0140-6736(04)16257-0 – ident: e_1_2_11_14_1 doi: 10.1016/j.celrep.2013.03.024 – ident: e_1_2_11_64_1 doi: 10.1371/journal.pone.0151806 – volume: 22 start-page: 797 year: 2016 ident: e_1_2_11_63_1 article-title: Pathogenic mutations in TULP1 responsible for retinitis pigmentosa identified in consanguineous familial cases publication-title: Mol Vis – ident: e_1_2_11_21_1 doi: 10.1074/jbc.M110636200 – ident: e_1_2_11_11_1 doi: 10.1038/415092a – ident: e_1_2_11_74_1 doi: 10.1371/journal.pone.0063205
SSID	ssj0035499
Score	2.5594478
SecondaryResourceType	review_article
Snippet	The human eye is the organ that is able to react to light in order to provide sharp three‐dimensional and colored images. Unfortunately, the health of the eye... The human eye is the organ that is able to react to light in order to provide sharp three-dimensional and colored images. Unfortunately, the health of the eye...
SourceID	pubmedcentral proquest pubmed crossref wiley
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	399
SubjectTerms	achromatopsia Aging AMD Animal models Animals color Endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - pathology Endoplasmic Reticulum Stress Environmental changes ER stress Eye - metabolism Eye diseases Eye Diseases - physiopathology eyes glaucoma Humans Mutation neurodegernation Organic chemistry Protein folding Proteins retinal degeneration RGC RPE Signal Transduction Stress Unfolded Protein Response UPR VEGF vision
Title	ER stress and unfolded protein response in ocular health and disease
URI	https://onlinelibrary.wiley.com/doi/abs/10.1111%2Ffebs.14522 https://www.ncbi.nlm.nih.gov/pubmed/29802807 https://www.proquest.com/docview/2170574141 https://www.proquest.com/docview/2045281119 https://www.proquest.com/docview/2221060431 https://pubmed.ncbi.nlm.nih.gov/PMC6583901
Volume	286
WOSCitedRecordID	wos000456553900011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVWIB databaseName: Wiley Online Library Free Content customDbUrl: eissn: 1742-4658 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035499 issn: 1742-464X databaseCode: WIN dateStart: 20050101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1742-4658 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035499 issn: 1742-464X databaseCode: DRFUL dateStart: 20050101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3di9QwEB_OU9AXP-78qJ5LRBEUCk2bbRrw5bzbReFY5PRw30qSJrhwdmX3VvC_dyZp6y0nByL0oSXTkiYzycxk5jcAr4qxbTRuNWnWoIkifCZTkxl8lI02BMdSuQDieiJns2o-V5924F2fCxPxIQaHG0lGWK9JwLVZXxJy78wa5Rz1B1yAueBUvuDrx1m_DBdk-MRsyDwVpZh32KQUxvPn1e3d6IqKeTVS8rIGG7ag6b3_6_x9uNupnuww8soD2HHtHuwftmh2f__FXrMQDBq87Htw-6gvBLcPx5NTFlNKmG4btkGWPG9cwwLEw6Jlqxhm6xjeL0NYK4vZlYG8OwF6CGfTyZejD2lXfCG1YyHz1JSK-7HMy8Z47i3qUZXSis7OTW6kLnWmrNG6NJp7pa3SkiwhJ5z0hdeVLh7Bbrts3RNgXHIryoZLJ4wwmcfLWhxTWThV6jxL4E0_CbXtkMmpQMZ53VsoNFx1GK4EXg60PyIex1-pDvq5rDuZXNc5IQehAiV4Ai-GZhxLOiLRrVtukIYQ5iv8mLqGJkczuSRQogQeR_YYupKris6qZQJyi3EGAkLz3m5pF98CqjeqguR_SuBtYJxr_q6eTt5_DndP_4X4GdzB6VPRf3QAuxerjXsOt-zPi8V6NYIbcl6N4Obx6fTsZBRE6TfX1iB7
linkProvider	Wiley-Blackwell
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3daxQxEB-0CvXFaqt2basRRbCwsB-5zeaxtne0eB6iFe9tSbIJHrR7ctcT_O-dSXbXHpWCCPuQJbNLNpnZzExmfgPwJh-YWuFWEyc1mijcJSLWicZbUStNcCyl9SCuYzGZlNOp_NTG5lAuTMCH6B1uJBn-f00CTg7pa1LurF6ioKMCcRfucdQ0qHLDt7NJ9yPOyfQJ-ZBZzAs-bdFJKZDnz7Pr-9ENJfNmrOR1HdZvQqOt_xz-I3jYap_sKLDLY7hjm23YOWrQ8r78xd4yHw_qHe3bsHnc1YLbgZPhZxaySphqarZCrryobc08ysOsYYsQaWsZtuc-spWFBEtP3h4CPYGvo-H58Wnc1l-IzYCLLNaFTN1AZEWtXeoMqlKlVJKOz3WmhSpUIo1WqtAqdVIZqQQZQ5Zb4XKnSpU_hY1m3thdYKlIDS_qVFiuuU4cXsbgpIrcykJlSQTvulWoTAtOTjUyLqrOSKHpqvx0RfC6p_0RIDn-SrXfLWbViuWyygg8CHUonkbwqu_GuaRTEtXY-QppCGS-xJfJW2gytJQLwiWK4Fngj34omSzpuFpEINY4pycgQO_1nmb23QN7ozZILqgIDj3n3PJ11Wj4_otvPf8X4peweXr-cVyNzyYf9uABLqUM7qR92LharOwB3Dc_r2bLxQsvSb8B660iEQ
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9RAEB_0KupL1VZrbNUVRVAI5GMvm31sexcUj6NUC_cW9hMP2ly56wn-9-7sJmmPSkGEPGzYScjOzmRndmZ_A_AhHyot3FITJ9q5KNQmLJaJdLdMC4lwLKXxIK4TNp2Wsxk_aXNz8CxMwIfoN9xQM_z_GhXcXGp7Q8utkSun6M6AuA9bFKvIDGBrdFqdTbpfcY7OTzgRmcW0oLMWnxRTea6f3lyRbpmZt7Mlb1qxfhmqnvznAJ7Cdmt_ksMgMM_gnml2YPewcb73xW_ykfiMUL_VvgOPjrtqcLswGp-ScK6EiEaTtZPLc2008TgP84YsQ66tIa698LmtJByx9ORtGOg5nFXjH8df4rYCQ6yGlGWxLHhqhywrtLSpVc6YKrngGECXmWSiEAlXUohCitRyobhg6A4ZapjNrShF_gIGzaIxL4GkLFW00CkzVFKZWHcp5ZjKcsMLkSURfOpmoVYtPDlWyTivOzcF2VV7dkXwvqe9DKAcf6U66CazbhVzVWcIH-SsKJpG8K7vdrzEOIlozGLtaBBmvnQv43fQZM5XLhCZKIK9IB_9p2S8xIA1i4BtSE5PgJDemz3N_KeH9nb2IG5CRfDZS84do6ur8dF333r1L8Rv4eHJqKonX6ff9uGxm0ke9pMOYHC1XJvX8ED9upqvlm9aVfoD1lgiug
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=ER+stress+and+unfolded+protein+response+in+ocular+health+and+disease&rft.jtitle=The+FEBS+journal&rft.au=Kroeger%2C+Heike&rft.au=Chiang%2C+Wei%E2%80%90Chieh&rft.au=Felden%2C+Julia&rft.au=Nguyen%2C+Amanda&rft.date=2019-01-01&rft.issn=1742-464X&rft.eissn=1742-4658&rft.volume=286&rft.issue=2&rft.spage=399&rft.epage=412&rft_id=info:doi/10.1111%2Ffebs.14522&rft.externalDBID=10.1111%252Ffebs.14522&rft.externalDocID=FEBS14522
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1742-464X&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1742-464X&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1742-464X&client=summon