Emergence and diversification of fly pigmentation through evolution of a gene regulatory module

The typical pattern of morphological evolution associated with the radiation of a group of related species is the emergence of a novel trait and its subsequent diversification. Yet the genetic mechanisms associated with these two evolutionary steps are poorly characterized. Here, we show that a spot...

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Vydáno v:	Science (American Association for the Advancement of Science) Ročník 339; číslo 6126; s. 1423
Hlavní autoři:	Arnoult, Laurent, Su, Kathy F Y, Manoel, Diogo, Minervino, Caroline, Magriña, Justine, Gompel, Nicolas, Prud'homme, Benjamin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 22.03.2013
Témata:	Animals Binding Sites Biological Evolution Drosophila - anatomy & histology Drosophila - genetics Drosophila - growth & development Drosophila melanogaster - anatomy & histology Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Evolution, Molecular Gene Expression Profiling Gene Expression Regulation, Developmental Gene Regulatory Networks Genes, Insect Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Phylogeny Pigmentation - genetics Pigments, Biological - analysis Pigments, Biological - metabolism Pupa RNA Interference Transcription Factors - genetics Transcription Factors - metabolism Wings, Animal - anatomy & histology Wings, Animal - chemistry
ISSN:	1095-9203, 1095-9203
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Shrnutí:	The typical pattern of morphological evolution associated with the radiation of a group of related species is the emergence of a novel trait and its subsequent diversification. Yet the genetic mechanisms associated with these two evolutionary steps are poorly characterized. Here, we show that a spot of dark pigment on fly wings emerged from the assembly of a novel gene regulatory module in which a set of pigmentation genes evolved to respond to a common transcriptional regulator determining their spatial distribution. The primitive wing spot pattern subsequently diversified through changes in the expression pattern of this regulator. These results suggest that the genetic changes underlying the emergence and diversification of wing pigmentation patterns are partitioned within genetic networks.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1095-9203 1095-9203
DOI:	10.1126/science.1233749