Raltegravir with Optimized Background Therapy for Resistant HIV-1 Infection

For patients infected with multidrug-resistant human immunodeficiency virus type 1 (HIV-1), therapeutic options are limited. Raltegravir is a new molecule that inhibits HIV integrase. In two phase 3 studies, raltegravir was found to be superior to placebo, in the context of optimized background anti...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 359; no. 4; pp. 339 - 354
Main Authors:	Steigbigel, Roy T, Cooper, David A, Kumar, Princy N, Eron, Joseph E, Schechter, Mauro, Markowitz, Martin, Loutfy, Mona R, Lennox, Jeffrey L, Gatell, Jose M, Rockstroh, Jurgen K, Katlama, Christine, Yeni, Patrick, Lazzarin, Adriano, Clotet, Bonaventura, Zhao, Jing, Chen, Joshua, Ryan, Desmond M, Rhodes, Rand R, Killar, John A, Gilde, Lucinda R, Strohmaier, Kim M, Meibohm, Anne R, Miller, Michael D, Hazuda, Daria J, Nessly, Michael L, DiNubile, Mark J, Isaacs, Robin D, Nguyen, Bach-Yen, Teppler, Hedy
Format:	Journal Article
Language:	English
Published:	Boston, MA Massachusetts Medical Society 24.07.2008
Subjects:	Adolescent Adult Aged Antiretroviral drugs Biological and medical sciences CD4 Lymphocyte Count Clinical trials Double-Blind Method Drug dosages Drug Resistance, Viral Drug therapy Drug Therapy, Combination Female Follow-Up Studies General aspects HIV HIV Infections - drug therapy HIV Integrase Inhibitors - adverse effects HIV Integrase Inhibitors - therapeutic use HIV Integrase Inhibitors/adverse effects/therapeutic use HIV-1 - genetics HIV-1 - isolation & purification HIV-1/genetics/isolation & purification Human health sciences Human immunodeficiency virus Human viral diseases Humans Immunologie & maladie infectieuse Immunology & infectious disease Infectious diseases Logistic Models Male Medical sciences Middle Aged Neoplasms - etiology Organic Chemicals - adverse effects Organic Chemicals - therapeutic use Organic Chemicals/adverse effects/therapeutic use Pyrrolidinones Raltegravir Potassium RNA, Viral - blood Sciences de la santé humaine Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Immunopathology Antiretroviral agent HIV-1 virus Retroviridae AIDS Immune deficiency Lentivirus Infection Virus Medicine Resistance Integrase inhibitor Treatment Viral disease Antiviral Human immunodeficiency virus Raltegravir
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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