Fetal sex and the circulating renin–angiotensin system during early gestation in women who later develop preeclampsia or gestational hypertension

There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1–7) in the maternal circulation during pregnancy. To determine whether at 15 weeks’ gestation plasma levels of Ang II and Ang-(1–7), as well as levels of prorenin and Ang-converting enzyme (ACE), predicted...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of human hypertension Vol. 28; no. 2; pp. 133 - 139
Main Authors:	Sykes, S D, Pringle, K G, Zhou, A, Dekker, G A, Roberts, C T, Lumbers, E R
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.02.2014 Nature Publishing Group
Subjects:	631/443/494 631/443/592 692/699/75/243/793 Adult Angiotensin Angiotensin I - blood Angiotensin II Angiotensin II - blood Biomarkers - blood Blood Pressure Body mass index Case-Control Studies Development and progression Epidemiology Female Fetuses Gestation Gestational Age Health Administration Humans Hypertension Hypertension in pregnancy Hypertension, Pregnancy-Induced - blood Hypertension, Pregnancy-Induced - diagnosis Hypertension, Pregnancy-Induced - etiology Hypertension, Pregnancy-Induced - physiopathology Male Medicine Medicine & Public Health original-article Peptide Fragments - blood Peptidyl-Dipeptidase A - blood Plasma levels Pre-eclampsia Pre-Eclampsia - blood Pre-Eclampsia - diagnosis Pre-Eclampsia - etiology Pre-Eclampsia - physiopathology Preeclampsia Pregnancy Public Health Renin Renin - blood Renin-Angiotensin System Risk Assessment Risk Factors Sex Sex Determination Analysis Sex Factors Ultrasonography, Doppler Ultrasonography, Prenatal Young Adult gestational hypertension prorenin preeclampsia angiotensin II angiotensin-(1–7) angiotensin-converting enzyme
ISSN:	0950-9240, 1476-5527, 1476-5527
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1–7) in the maternal circulation during pregnancy. To determine whether at 15 weeks’ gestation plasma levels of Ang II and Ang-(1–7), as well as levels of prorenin and Ang-converting enzyme (ACE), predicted the development of gestational hypertension (GH) or preeclampsia (PreE) and were associated with estimates of fetal and maternal health, women who later developed GH ( n =50) or PreE ( n =50) were compared with body mass index-matched controls ( n =100). Women who subsequently developed PreE or GH had increased Ang-(1–7) levels at 15 weeks’ gestation compared with women with normal pregnancies. When separated by fetal sex, this difference was seen only in women carrying a female fetus. Prorenin and ACE concentrations were not useful biomarkers for the prediction of either PreE or GH at 15 weeks’ gestation. Women with a male fetus who developed PreE and women who subsequently developed GH had increased blood pressures at 15 weeks’ gestation compared with women with normal pregnancies, suggesting that these women were on an early trajectory for the development of hypertension. We propose that measurement of Ang-(1–7) during early gestation could be useful in predicting, those women who will go on to develop new-onset hypertension in pregnancy.
AbstractList	There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1-7) in the maternal circulation during pregnancy. To determine whether at 15 weeks' gestation plasma levels of Ang II and Ang-(1-7), as well as levels of prorenin and Ang-converting enzyme (ACE), predicted the development of gestational hypertension (GH) or preeclampsia (PreE) and were associated with estimates of fetal and maternal health, women who later developed GH (n = 50) or PreE (n = 50) were compared with body mass index-matched controls (n = 100). Women who subsequently developed PreE or GH had increased Ang-(1-7) levels at 15 weeks' gestation compared with women with normal pregnancies. When separated by fetal sex, this difference was seen only in women carrying a female fetus. Prorenin and ACE concentrations were not useful biomarkers for the prediction of either PreE or GH at 15 weeks' gestation. Women with a male fetus who developed PreE and women who subsequently developed GH had increased blood pressures at 15 weeks' gestation compared with women with normal pregnancies, suggesting that these women were on an early trajectory for the development of hypertension. We propose that measurement of Ang-(1-7) during early gestation could be useful in predicting, those women who will go on to develop new-onset hypertension in pregnancy. Journal of Human Hypertension (2014) 28, 133-139; doi: 10.1038/jhh.2013.51; published online 20 June 2013 Keywords: angiotensin II; angiotensin-(1-7); preeclampsia; gestational hypertension; prorenin; angiotensin-converting enzyme There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1-7) in the maternal circulation during pregnancy. To determine whether at 15 weeks' gestation plasma levels of Ang II and Ang-(1-7), as well as levels of prorenin and Ang-converting enzyme (ACE), predicted the development of gestational hypertension (GH) or preeclampsia (PreE) and were associated with estimates of fetal and maternal health, women who later developed GH (n = 50) or PreE (n = 50) were compared with body mass index-matched controls (n = 100). Women who subsequently developed PreE or GH had increased Ang-(1-7) levels at 15 weeks' gestation compared with women with normal pregnancies. When separated by fetal sex, this difference was seen only in women carrying a female fetus. Prorenin and ACE concentrations were not useful biomarkers for the prediction of either PreE or GH at 15 weeks' gestation. Women with a male fetus who developed PreE and women who subsequently developed GH had increased blood pressures at 15 weeks' gestation compared with women with normal pregnancies, suggesting that these women were on an early trajectory for the development of hypertension. We propose that measurement of Ang-(1-7) during early gestation could be useful in predicting, those women who will go on to develop new-onset hypertension in pregnancy. There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1-7) in the maternal circulation during pregnancy. To determine whether at 15 weeks' gestation plasma levels of Ang II and Ang-(1-7), as well as levels of prorenin and Ang-converting enzyme (ACE), predicted the development of gestational hypertension (GH) or preeclampsia (PreE) and were associated with estimates of fetal and maternal health, women who later developed GH (n=50) or PreE (n=50) were compared with body mass index-matched controls (n=100). Women who subsequently developed PreE or GH had increased Ang-(1-7) levels at 15 weeks' gestation compared with women with normal pregnancies. When separated by fetal sex, this difference was seen only in women carrying a female fetus. Prorenin and ACE concentrations were not useful biomarkers for the prediction of either PreE or GH at 15 weeks' gestation. Women with a male fetus who developed PreE and women who subsequently developed GH had increased blood pressures at 15 weeks' gestation compared with women with normal pregnancies, suggesting that these women were on an early trajectory for the development of hypertension. We propose that measurement of Ang-(1-7) during early gestation could be useful in predicting, those women who will go on to develop new-onset hypertension in pregnancy.There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1-7) in the maternal circulation during pregnancy. To determine whether at 15 weeks' gestation plasma levels of Ang II and Ang-(1-7), as well as levels of prorenin and Ang-converting enzyme (ACE), predicted the development of gestational hypertension (GH) or preeclampsia (PreE) and were associated with estimates of fetal and maternal health, women who later developed GH (n=50) or PreE (n=50) were compared with body mass index-matched controls (n=100). Women who subsequently developed PreE or GH had increased Ang-(1-7) levels at 15 weeks' gestation compared with women with normal pregnancies. When separated by fetal sex, this difference was seen only in women carrying a female fetus. Prorenin and ACE concentrations were not useful biomarkers for the prediction of either PreE or GH at 15 weeks' gestation. Women with a male fetus who developed PreE and women who subsequently developed GH had increased blood pressures at 15 weeks' gestation compared with women with normal pregnancies, suggesting that these women were on an early trajectory for the development of hypertension. We propose that measurement of Ang-(1-7) during early gestation could be useful in predicting, those women who will go on to develop new-onset hypertension in pregnancy. There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1–7) in the maternal circulation during pregnancy. To determine whether at 15 weeks’ gestation plasma levels of Ang II and Ang-(1–7), as well as levels of prorenin and Ang-converting enzyme (ACE), predicted the development of gestational hypertension (GH) or preeclampsia (PreE) and were associated with estimates of fetal and maternal health, women who later developed GH ( n =50) or PreE ( n =50) were compared with body mass index-matched controls ( n =100). Women who subsequently developed PreE or GH had increased Ang-(1–7) levels at 15 weeks’ gestation compared with women with normal pregnancies. When separated by fetal sex, this difference was seen only in women carrying a female fetus. Prorenin and ACE concentrations were not useful biomarkers for the prediction of either PreE or GH at 15 weeks’ gestation. Women with a male fetus who developed PreE and women who subsequently developed GH had increased blood pressures at 15 weeks’ gestation compared with women with normal pregnancies, suggesting that these women were on an early trajectory for the development of hypertension. We propose that measurement of Ang-(1–7) during early gestation could be useful in predicting, those women who will go on to develop new-onset hypertension in pregnancy.
Audience	Academic
Author	Zhou, A Lumbers, E R Sykes, S D Pringle, K G Dekker, G A Roberts, C T
Author_xml	– sequence: 1 givenname: S D surname: Sykes fullname: Sykes, S D organization: Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, Robinson Institute, University of Adelaide – sequence: 2 givenname: K G surname: Pringle fullname: Pringle, K G organization: Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle – sequence: 3 givenname: A surname: Zhou fullname: Zhou, A organization: Robinson Institute, University of Adelaide – sequence: 4 givenname: G A surname: Dekker fullname: Dekker, G A organization: Robinson Institute, University of Adelaide, Women’s and Children’s Division, Lyell McEwin Hospital – sequence: 5 givenname: C T surname: Roberts fullname: Roberts, C T organization: Robinson Institute, University of Adelaide – sequence: 6 givenname: E R surname: Lumbers fullname: Lumbers, E R email: eugenie.lumbers@newcastle.edu.au organization: Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/23782994$$D View this record in MEDLINE/PubMed
BookMark	eNp9kl9r1TAYxoNM3Nn0ynsJCCJoj0natM3lGE6FgTd6HdL07WkOaVKTVj13-w77hvskpp7p_jAlkEDye9734c1zhA6cd4DQc0rWlOT1u23frxmh-ZrTR2hFi6rMOGfVAVoRwUkmWEEO0VGMW0KWx_oJOmR5VTMhihW6PINJWRzhJ1auxVMPWJugZ6sm4zY4gDPu6uJSuY3xE7hoHI67OMGA2zksBKhgd3gDcUoK73ACfvgB0t57nKpAwC18B-tHPAYAbdUwRqOwDzeiZKDfjRB-N_DuKXrcKRvh2fV5jL6evf9y-jE7__zh0-nJeaZ5UU5ZU7CW1bwDXrYdtEXe1KTTuQateNMJ4KQsa9VBnbegK-CiFoI0vMnZAnGRH6PX-7pj8N_mZEYOJmqwVjnwc5S0EKRidVku6Mt76NbPIRmPkpUF4YIzWvyPSpPnlOWclTfURlmQxnV-CkovreVJzitRVqLiiVo_QKXVwmB0SkBn0v0dwatbgh6Unfro7bwMON4FX1y7nJsBWjkGM6iwk39CkYA3e0AHH2OA7i9CiVwiJ1Pk5BI5yWmi6T1am_23JsPG_kPzdq-J4xIiCLcG9QD-CwN16e0
CitedBy_id	crossref_primary_10_3389_fimmu_2022_861245 crossref_primary_10_1016_j_preghy_2016_01_006 crossref_primary_10_3390_ijms241612728 crossref_primary_10_1097_HJH_0000000000000212 crossref_primary_10_1080_14767058_2018_1488163 crossref_primary_10_3389_fped_2017_00144 crossref_primary_10_1038_s41440_022_00959_4 crossref_primary_10_1038_jhh_2014_42 crossref_primary_10_1152_physrev_00023_2016 crossref_primary_10_1186_s13293_020_00299_3 crossref_primary_10_1016_j_preghy_2015_11_004 crossref_primary_10_1097_MD_0000000000012498 crossref_primary_10_1093_molehr_gaaa030 crossref_primary_10_1016_j_placenta_2017_01_119 crossref_primary_10_1017_thg_2023_38 crossref_primary_10_1111_1471_0528_14163 crossref_primary_10_3109_10641955_2014_988352 crossref_primary_10_1096_fj_202301480 crossref_primary_10_1016_j_mehy_2015_06_001 crossref_primary_10_3389_fendo_2019_00563 crossref_primary_10_1007_s12020_020_02296_3 crossref_primary_10_14814_phy2_12586 crossref_primary_10_18203_2320_1770_ijrcog20251230 crossref_primary_10_1038_s41440_020_00610_0 crossref_primary_10_1016_j_preghy_2019_09_020 crossref_primary_10_1016_j_preghy_2018_10_003 crossref_primary_10_1016_j_scitotenv_2023_165674 crossref_primary_10_1038_s41598_020_75969_8 crossref_primary_10_3389_fphys_2020_590787 crossref_primary_10_1038_s41598_020_76196_x
Cites_doi	10.1111/j.1471-0528.1975.tb00700.x 10.1016/j.ajog.2004.03.004 10.1016/j.preghy.2012.01.001 10.1042/cs0790403 10.1016/S0140-6736(06)68397-9 10.1097/00004872-199816060-00017 10.1093/ajh/2.5.403 10.1172/JCI4106 10.1161/01.HYP.37.1.72 10.1111/j.1471-0528.1991.tb13361.x 10.1161/HYPERTENSIONAHA.109.140061 10.1016/j.cellsig.2012.02.005 10.1158/1535-7163.MCT-09-0161 10.1111/j.1471-0528.1986.tb07830.x 10.1016/0005-2744(70)90090-2 10.1053/j.semperi.2009.02.010 10.1590/S0100-879X2007000400018 10.1016/j.placenta.2010.12.006 10.1186/1477-7827-8-135 10.1016/j.placenta.2005.02.015 10.1152/ajpregu.90724.2008 10.1007/s12020-007-9022-1 10.1136/bmj.d1875 10.1095/biolreprod.112.099861 10.1016/S0029-7844(97)00660-1 10.1016/j.placenta.2011.09.020 10.1001/jama.290.22.2945 10.1074/jbc.M200581200 10.1111/j.1471-0528.2000.tb13312.x 10.1152/ajpregu.2001.280.4.R994 10.1038/nm1429 10.1016/0960-0760(91)90270-F 10.1016/j.autrev.2004.07.002 10.1385/ENDO:18:3:239 10.1016/j.regpep.2006.12.014 10.1177/1470320313477174
ContentType	Journal Article
Copyright	Macmillan Publishers Limited 2013 COPYRIGHT 2014 Nature Publishing Group Copyright Nature Publishing Group Feb 2014 Macmillan Publishers Limited 2013.
Copyright_xml	– notice: Macmillan Publishers Limited 2013 – notice: COPYRIGHT 2014 Nature Publishing Group – notice: Copyright Nature Publishing Group Feb 2014 – notice: Macmillan Publishers Limited 2013.
CorporateAuthor	on behalf of the SCOPE consortium SCOPE consortium
CorporateAuthor_xml	– name: on behalf of the SCOPE consortium – name: SCOPE consortium
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7T5 7X7 7XB 88E 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8
DOI	10.1038/jhh.2013.51
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Immunology Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database ProQuest Biological Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE ProQuest Central Student MEDLINE - Academic ProQuest Central Student
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Public Health
EISSN	1476-5527
EndPage	139
ExternalDocumentID	3175451971 A357967975 23782994 10_1038_jhh_2013_51
Genre	Research Support, Non-U.S. Gov't Journal Article Comparative Study
GroupedDBID	--- -Q- 0R~ 29K 2WC 36B 39C 3V. 4.4 406 53G 5GY 5RE 70F 7X7 88E 8AO 8FI 8FJ 8R4 8R5 A8Z AACDK AANZL AASML AATNV AAYZH AAZLF ABAKF ABAWZ ABCQX ABDBF ABJNI ABLJU ABOCM ABUWG ABZZP ACAOD ACGFS ACKTT ACPRK ACRQY ACUHS ACZOJ ADBBV ADHDB AEFQL AEJRE AEMSY AENEX AEVLU AEXYK AFBBN AFKRA AFSHS AGAYW AGHAI AGQEE AHMBA AHSBF AIGIU AILAN AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF AXYYD B0M BAWUL BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CAG CCPQU COF CS3 D-I DIK DNIVK DPUIP DU5 E3Z EAD EAP EBC EBD EBLON EBS EE. EIOEI EJD EMB EMK EMOBN EPL ESX F5P FDQFY FERAY FIGPU FIZPM FSGXE FYUFA HCIFZ HMCUK HZ~ IAO IHR IHW INH INR ITC IWAJR JSO JZLTJ KQ8 L7B M1P M7P NAO NQJWS O9- OK1 OVD P2P PQQKQ PROAC PSQYO Q2X RNS RNT RNTTT ROL SNX SNYQT SOHCF SOJ SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TEORI TR2 TSG TUS UKHRP W2D YYP ZXP ~8M AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC AEZWR AFDZB AFFHD AFHIU AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7T5 7XB 8FE 8FH 8FK AZQEC DWQXO ESTFP GNUQQ H94 K9. LK8 PKEHL PQEST PQUKI PRINS 7X8 PUEGO
ID	FETCH-LOGICAL-c546t-b42d285fe56dfed43b80fc3ceca5bf9e50668afe83dec7e598990b5b32c3ce593
IEDL.DBID	M7P
ISICitedReferencesCount	26
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000329441300012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0950-9240 1476-5527
IngestDate	Sun Sep 28 08:19:07 EDT 2025 Fri Oct 03 11:00:09 EDT 2025 Mon Oct 06 17:24:54 EDT 2025 Sat Nov 29 13:03:06 EST 2025 Sat Nov 29 10:04:14 EST 2025 Thu May 22 21:00:10 EDT 2025 Mon Jul 21 06:05:04 EDT 2025 Sat Nov 29 05:32:49 EST 2025 Tue Nov 18 19:50:38 EST 2025 Fri Feb 21 02:39:45 EST 2025
IsPeerReviewed	true
IsScholarly	true
Issue	2
Keywords	gestational hypertension prorenin preeclampsia angiotensin II angiotensin-(1–7) angiotensin-converting enzyme
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c546t-b42d285fe56dfed43b80fc3ceca5bf9e50668afe83dec7e598990b5b32c3ce593
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23
PMID	23782994
PQID	1475123526
PQPubID	35973
PageCount	7
ParticipantIDs	proquest_miscellaneous_1490728669 proquest_journals_2640595214 proquest_journals_1475123526 gale_infotracmisc_A357967975 gale_infotracacademiconefile_A357967975 gale_healthsolutions_A357967975 pubmed_primary_23782994 crossref_primary_10_1038_jhh_2013_51 crossref_citationtrail_10_1038_jhh_2013_51 springer_journals_10_1038_jhh_2013_51
PublicationCentury	2000
PublicationDate	2014-02-01
PublicationDateYYYYMMDD	2014-02-01
PublicationDate_xml	– month: 02 year: 2014 text: 2014-02-01 day: 01
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Journal of human hypertension
PublicationTitleAbbrev	J Hum Hypertens
PublicationTitleAlternate	J Hum Hypertens
PublicationYear	2014
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Carbajo-Lozoya, Lutz, Feng, Kroll, Hammes, Wieland (CR31) 2012; 24 Duley (CR2) 2009; 33 Soto-Pantoja, Menon, Gallagher, Tallant (CR34) 2009; 8 Jasovic-Siveska, Jasovic (CR39) 2011; 82 Roberts, Escudero (CR8) 2012; 2 Heitsch, Brovkovych, Malinski, Wiemer (CR29) 2001; 37 Gilbert, Nijland (CR4) 2008; 295 Sesso, Buring, Rifai, Blake, Gaziano, Ridker (CR38) 2003; 290 Silvestre, Levy (CR30) 2004; 188 Anton, Merrill, Neves, Brosnihan (CR33) 2007; 32 Khan, Wojdyla, Say, Gulmezoglu, Van Look (CR1) 2006; 367 Symonds, Broughton Pipkin, Craven (CR16) 1975; 82 Simmons, Hennessy, Gillin, Jeremy (CR22) 2000; 107 Wallukat, Homuth, Fischer, Lindschau, Horstkamp, Jupner (CR24) 1999; 103 Hanssens, Keirse, Spitz, van Assche (CR11) 1991; 98 Machado, Santos, Andrade (CR32) 2001; 280 Valdes, Neves, Anton, Corthorn, Chacon, Germain (CR20) 2006; 27 Siddiqui, Irani, Blackwell, Ramin, Kellems, Xia (CR25) 2010; 55 Bachmann, Feldmer, Ganten, Stock, Ganten (CR5) 1991; 40 Velloso, Vieira, Cabral, Kalapothakis, Santos (CR17) 2007; 40 Merrill, Karoly, Chen, Ferrario, Brosnihan (CR15) 2002; 18 Smookler, Severs, Kinnard, Buckley (CR28) 1966; 153 Kooner, May, Peart, Mathias (CR27) 1997; 273 CR7 Clauser, Gaillard, Wei, Corvol (CR6) 1989; 2 Pringle, Tadros, Callister, Lumbers (CR19) 2011; 32 Khong, De Wolf, Robertson, Brosens (CR21) 1986; 93 Dechend, Muller, Wallukat, Homuth, Krause, Dudenhausen (CR26) 2005; 4 Vickers, Hales, Kaushik, Dick, Gavin, Tang (CR35) 2002; 277 Danser, Derkx, Schalekamp, Hense, Riegger, Schunkert (CR3) 1998; 16 Nogueira, Souza Santos, Simoes, Cabral, Vieira, Drumond (CR12) 2007; 141 Venkatesha, Toporsian, Lam, Hanai, Mammoto, Kim (CR36) 2006; 12 North, McCowan, Dekker, Poston, Chan, Stewart (CR10) 2011; 342 Piquilloud, Reinharz, Roth (CR40) 1970; 206 Marques, Pringle, Conquest, Hirst, Markus, Sarris (CR18) 2011; 32 Anton, Merrill, Neves, Gruver, Moorefield, Brosnihan (CR9) 2010; 8 Baker, Broughton Pipkin, Symonds (CR13) 1990; 79 Laresgoiti-Servitje, Gomez-Lopez (CR23) 2012; 87 McKeeman, Ardill, Caldwell, Hunter, McClure (CR37) 2004; 191 Langer, Grima, Coquard, Bader, Schlaeder, Imbs (CR14) 1998; 91 L Anton (BFjhh201351_CR9) 2010; 8 FZ Marques (BFjhh201351_CR18) 2011; 32 Y Piquilloud (BFjhh201351_CR40) 1970; 206 KS Khan (BFjhh201351_CR1) 2006; 367 M Hanssens (BFjhh201351_CR11) 1991; 98 J Bachmann (BFjhh201351_CR5) 1991; 40 KG Pringle (BFjhh201351_CR19) 2011; 32 R Dechend (BFjhh201351_CR26) 2005; 4 JS Gilbert (BFjhh201351_CR4) 2008; 295 J Carbajo-Lozoya (BFjhh201351_CR31) 2012; 24 DC Merrill (BFjhh201351_CR15) 2002; 18 G Wallukat (BFjhh201351_CR24) 1999; 103 JS Kooner (BFjhh201351_CR27) 1997; 273 RA North (BFjhh201351_CR10) 2011; 342 E Jasovic-Siveska (BFjhh201351_CR39) 2011; 82 AI Nogueira (BFjhh201351_CR12) 2007; 141 EM Symonds (BFjhh201351_CR16) 1975; 82 HH Smookler (BFjhh201351_CR28) 1966; 153 C Vickers (BFjhh201351_CR35) 2002; 277 RD Machado (BFjhh201351_CR32) 2001; 280 GC McKeeman (BFjhh201351_CR37) 2004; 191 JM Roberts (BFjhh201351_CR8) 2012; 2 DR Soto-Pantoja (BFjhh201351_CR34) 2009; 8 AH Danser (BFjhh201351_CR3) 1998; 16 S Venkatesha (BFjhh201351_CR36) 2006; 12 EP Velloso (BFjhh201351_CR17) 2007; 40 AH Siddiqui (BFjhh201351_CR25) 2010; 55 L Duley (BFjhh201351_CR2) 2009; 33 H Heitsch (BFjhh201351_CR29) 2001; 37 L Anton (BFjhh201351_CR33) 2007; 32 G Valdes (BFjhh201351_CR20) 2006; 27 BFjhh201351_CR7 PN Baker (BFjhh201351_CR13) 1990; 79 LA Simmons (BFjhh201351_CR22) 2000; 107 JS Silvestre (BFjhh201351_CR30) 2004; 188 HD Sesso (BFjhh201351_CR38) 2003; 290 E Clauser (BFjhh201351_CR6) 1989; 2 B Langer (BFjhh201351_CR14) 1998; 91 E Laresgoiti-Servitje (BFjhh201351_CR23) 2012; 87 TY Khong (BFjhh201351_CR21) 1986; 93 15507947 - Am J Obstet Gynecol. 2004 Oct;191(4):1240-6 21215447 - Placenta. 2011 Mar;32(3):214-21 22374305 - Cell Signal. 2012 Jun;24(6):1261-9 1958553 - J Steroid Biochem Mol Biol. 1991;40(4-6):511-5 16751767 - Nat Med. 2006 Jun;12 (6):642-9 15652781 - Autoimmun Rev. 2005 Jan;4(1):61-5 19464502 - Semin Perinatol. 2009 Jun;33(3):130-7 4315054 - Biochim Biophys Acta. 1970 Apr 22;206(1):136-42 22018415 - Placenta. 2011 Dec;32(12):956-62 2004051 - Br J Obstet Gynaecol. 1991 Feb;98(2):155-61 2171863 - Clin Sci (Lond). 1990 Oct;79(4):403-8 1180953 - Br J Obstet Gynaecol. 1975 Aug;82(8):643-50 10826585 - BJOG. 2000 May;107(5):678-85 9469275 - Obstet Gynecol. 1998 Feb;91(2):196-202 23438673 - J Renin Angiotensin Aldosterone Syst. 2014 Dec;15(4):523-31 9663926 - J Hypertens. 1998 Jun;16(6):853-62 19509262 - Mol Cancer Ther. 2009 Jun;8(6):1676-83 18971349 - Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1941-52 22745921 - Pregnancy Hypertens. 2012 Apr 1;2(2):72-83 21050477 - Reprod Biol Endocrinol. 2010 Nov 04;8:135 14665655 - JAMA. 2003 Dec 10;290(22):2945-51 21474517 - BMJ. 2011 Apr 07;342:d1875 11247819 - Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R994-R1000 22649072 - Biol Reprod. 2012 Aug 23;87(2):36 3790464 - Br J Obstet Gynaecol. 1986 Oct;93(10):1049-59 15587684 - Bull Acad Natl Med. 2004;188(4):649-59; discussion 659 10194466 - J Clin Invest. 1999 Apr;103(7):945-52 12450315 - Endocrine. 2002 Aug;18(3):239-45 9435595 - Am J Physiol. 1997 Dec;273(6 Pt 2):H2620-6 2566314 - Am J Hypertens. 1989 May;2(5 Pt 1):403-10 16338465 - Placenta. 2006 Feb-Mar;27(2-3):200-7 4288411 - J Pharmacol Exp Ther. 1966 Sep;153(3):485-94 17401503 - Braz J Med Biol Res. 2007 Apr;40(4):583-90 16581405 - Lancet. 2006 Apr 1;367(9516):1066-74 11208759 - Hypertension. 2001 Jan;37(1):72-76 18008188 - Endocrine. 2007 Oct;32(2):212-8 19996068 - Hypertension. 2010 Feb;55(2):386-93 22384618 - Ginekol Pol. 2011 Nov;82(11):845-50 17291601 - Regul Pept. 2007 Jun 7;141(1-3):55-60 11815627 - J Biol Chem. 2002 Apr 26;277(17):14838-43
References_xml	– volume: 82 start-page: 643 issue: 8 year: 1975 end-page: 650 ident: CR16 article-title: Changes in the renin-angiotensin system in primigravidae with hypertensive disease of pregnancy publication-title: Br J Obstet Gynaecol doi: 10.1111/j.1471-0528.1975.tb00700.x – volume: 191 start-page: 1240 issue: 4 year: 2004 end-page: 1246 ident: CR37 article-title: Soluble vascular endothelial growth factor receptor-1 (sFlt-1) is increased throughout gestation in patients who have preeclampsia develop publication-title: Am J Obst Gynecol doi: 10.1016/j.ajog.2004.03.004 – volume: 2 start-page: 72 issue: 2 year: 2012 end-page: 83 ident: CR8 article-title: The placenta in preeclampsia publication-title: Pregnancy Hypertens doi: 10.1016/j.preghy.2012.01.001 – volume: 79 start-page: 403 issue: 4 year: 1990 end-page: 408 ident: CR13 article-title: Platelet angiotensin II binding and plasma renin concentration, plasma renin substrate and plasma angiotensin II in human pregnancy publication-title: Clin Sci (Lond) doi: 10.1042/cs0790403 – volume: 367 start-page: 1066 issue: 9516 year: 2006 end-page: 1074 ident: CR1 article-title: WHO analysis of causes of maternal death: a systematic review publication-title: Lancet doi: 10.1016/S0140-6736(06)68397-9 – volume: 16 start-page: 853 issue: 6 year: 1998 end-page: 862 ident: CR3 article-title: Determinants of interindividual variation of renin and prorenin concentrations: evidence for a sexual dimorphism of (pro)renin levels in humans publication-title: J Hypertens doi: 10.1097/00004872-199816060-00017 – volume: 2 start-page: 403 issue: 5 Pt 1 year: 1989 end-page: 410 ident: CR6 article-title: Regulation of angiotensinogen gene publication-title: Am JHypertens doi: 10.1093/ajh/2.5.403 – volume: 103 start-page: 945 issue: 7 year: 1999 end-page: 952 ident: CR24 article-title: Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor publication-title: J Clin Invest doi: 10.1172/JCI4106 – volume: 37 start-page: 72 issue: 1 year: 2001 end-page: 76 ident: CR29 article-title: Angiotensin-(1-7)-stimulated nitric oxide and superoxide release from endothelial cells publication-title: Hypertension doi: 10.1161/01.HYP.37.1.72 – volume: 98 start-page: 155 issue: 2 year: 1991 end-page: 161 ident: CR11 article-title: Angiotensin II levels in hypertensive and normotensive pregnancies publication-title: Br J Obstet Gynaecol doi: 10.1111/j.1471-0528.1991.tb13361.x – volume: 55 start-page: 386 issue: 2 year: 2010 end-page: 393 ident: CR25 article-title: Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: correlation with disease severity publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.109.140061 – volume: 24 start-page: 1261 issue: 6 year: 2012 end-page: 1269 ident: CR31 article-title: Angiotensin II modulates VEGF-driven angiogenesis by opposing effects of type 1 and type 2 receptor stimulation in the microvascular endothelium publication-title: Cell Signal doi: 10.1016/j.cellsig.2012.02.005 – volume: 8 start-page: 1676 issue: 6 year: 2009 end-page: 1683 ident: CR34 article-title: Angiotensin-(1-7) inhibits tumor angiogenesis in human lung cancer xenografts with a reduction in vascular endothelial growth factor publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-09-0161 – volume: 93 start-page: 1049 issue: 10 year: 1986 end-page: 1059 ident: CR21 article-title: Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants publication-title: Br J Obstet Gynaecol doi: 10.1111/j.1471-0528.1986.tb07830.x – volume: 206 start-page: 136 issue: 1 year: 1970 end-page: 142 ident: CR40 article-title: Studies on the angiotensin converting enzyme with different substrates publication-title: Biochim Biophys Acta doi: 10.1016/0005-2744(70)90090-2 – volume: 33 start-page: 130 issue: 3 year: 2009 end-page: 137 ident: CR2 article-title: The global impact of pre-eclampsia and eclampsia publication-title: Semin Perinatol doi: 10.1053/j.semperi.2009.02.010 – volume: 40 start-page: 583 issue: 4 year: 2007 end-page: 590 ident: CR17 article-title: Reduced plasma levels of angiotensin-(1-7) and renin activity in preeclamptic patients are associated with the angiotensin I- converting enzyme deletion/deletion genotype publication-title: Braz J Med Biol Res doi: 10.1590/S0100-879X2007000400018 – volume: 82 start-page: 845 issue: 11 year: 2011 end-page: 850 ident: CR39 article-title: Prediction of mild and severe preeclampsia with blood pressure measurements in first and second trimester of pregnancy publication-title: Ginekol Pol – volume: 153 start-page: 485 issue: 3 year: 1966 end-page: 494 ident: CR28 article-title: Centrally mediated cardiovascular effects of angiotensin II publication-title: J Pharmacol Exp Ther – volume: 32 start-page: 214 issue: 3 year: 2011 end-page: 221 ident: CR18 article-title: Molecular characterization of renin-angiotensin system components in human intrauterine tissues and fetal membranes from vaginal delivery and cesarean section publication-title: Placenta doi: 10.1016/j.placenta.2010.12.006 – volume: 273 start-page: H2620 issue: 6 Pt 2 year: 1997 end-page: H2626 ident: CR27 article-title: Separation of peripheral and central cardiovascular actions of angiotensin II publication-title: Am J Physiol – volume: 8 start-page: 135 year: 2010 ident: CR9 article-title: Angiotensin II and angiotensin-(1-7) decrease sFlt1 release in normal but not preeclamptic chorionic villi: an study publication-title: Reprod Biol Endocrinol doi: 10.1186/1477-7827-8-135 – volume: 27 start-page: 200 issue: 2-3 year: 2006 end-page: 207 ident: CR20 article-title: Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies publication-title: Placenta doi: 10.1016/j.placenta.2005.02.015 – volume: 295 start-page: R1941 issue: 6 year: 2008 end-page: R1952 ident: CR4 article-title: Sex differences in the developmental origins of hypertension and cardiorenal disease publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.90724.2008 – volume: 32 start-page: 212 issue: 2 year: 2007 end-page: 218 ident: CR33 article-title: Angiotensin-(1-7) inhibits endothelial cell tube formation in human umbilical vein endothelial cells through the AT(1-7) receptor publication-title: Endocrine doi: 10.1007/s12020-007-9022-1 – volume: 342 start-page: d1875 year: 2011 ident: CR10 article-title: Clinical risk prediction for pre-eclampsia in nulliparous women: development of model in international prospective cohort publication-title: BMJ doi: 10.1136/bmj.d1875 – volume: 87 start-page: 36 issue: 2 year: 2012 ident: CR23 article-title: The pathophysiology of preeclampsia involves altered levels of angiogenic factors promoted by hypoxia and autoantibody-mediated mechanisms publication-title: Biol Reprod doi: 10.1095/biolreprod.112.099861 – volume: 91 start-page: 196 issue: 2 year: 1998 end-page: 202 ident: CR14 article-title: Plasma active renin, angiotensin I, and angiotensin II during pregnancy and in preeclampsia publication-title: Obstet Gynecol doi: 10.1016/S0029-7844(97)00660-1 – volume: 32 start-page: 956 issue: 12 year: 2011 end-page: 962 ident: CR19 article-title: The expression and localization of the human placental prorenin/renin-angiotensin system throughout pregnancy: roles in trophoblast invasion and angiogenesis? publication-title: Placenta doi: 10.1016/j.placenta.2011.09.020 – volume: 290 start-page: 2945 issue: 22 year: 2003 end-page: 2951 ident: CR38 article-title: C-reactive protein and the risk of developing hypertension publication-title: JAMA doi: 10.1001/jama.290.22.2945 – volume: 188 start-page: 649 issue: 4 year: 2004 end-page: 659 ident: CR30 article-title: [The renin-angiotensin system and post-ischemic angiogenesis] publication-title: Bull Acad Natl Med – volume: 277 start-page: 14838 issue: 17 year: 2002 end-page: 14843 ident: CR35 article-title: Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase publication-title: J Biol Chem doi: 10.1074/jbc.M200581200 – volume: 107 start-page: 678 issue: 5 year: 2000 end-page: 685 ident: CR22 article-title: Uteroplacental blood flow and placental vascular endothelial growth factor in normotensive and pre-eclamptic pregnancy publication-title: BJOG doi: 10.1111/j.1471-0528.2000.tb13312.x – volume: 280 start-page: R994 issue: 4 year: 2001 end-page: R1000 ident: CR32 article-title: Mechanisms of angiotensin-(1-7)-induced inhibition of angiogenesis publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.2001.280.4.R994 – ident: CR7 – volume: 12 start-page: 642 issue: 6 year: 2006 end-page: 649 ident: CR36 article-title: Soluble endoglin contributes to the pathogenesis of preeclampsia publication-title: Nat Med doi: 10.1038/nm1429 – volume: 40 start-page: 511 issue: 4-6 year: 1991 end-page: 515 ident: CR5 article-title: Sexual dimorphism of blood pressure: possible role of the renin-angiotensin system publication-title: J Steroid Biochem Mol Biol doi: 10.1016/0960-0760(91)90270-F – volume: 4 start-page: 61 issue: 1 year: 2005 end-page: 65 ident: CR26 article-title: Activating auto-antibodies against the AT1 receptor in preeclampsia publication-title: Autoimmun Rev doi: 10.1016/j.autrev.2004.07.002 – volume: 18 start-page: 239 issue: 3 year: 2002 end-page: 245 ident: CR15 article-title: Angiotensin-(1-7) in normal and preeclamptic pregnancy publication-title: Endocrine doi: 10.1385/ENDO:18:3:239 – volume: 141 start-page: 55 issue: 1-3 year: 2007 end-page: 60 ident: CR12 article-title: The pregnancy-induced increase of plasma angiotensin-(1-7) is blunted in gestational diabetes publication-title: Regul Pept doi: 10.1016/j.regpep.2006.12.014 – volume: 55 start-page: 386 issue: 2 year: 2010 ident: BFjhh201351_CR25 publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.109.140061 – volume: 32 start-page: 214 issue: 3 year: 2011 ident: BFjhh201351_CR18 publication-title: Placenta doi: 10.1016/j.placenta.2010.12.006 – volume: 32 start-page: 212 issue: 2 year: 2007 ident: BFjhh201351_CR33 publication-title: Endocrine doi: 10.1007/s12020-007-9022-1 – volume: 277 start-page: 14838 issue: 17 year: 2002 ident: BFjhh201351_CR35 publication-title: J Biol Chem doi: 10.1074/jbc.M200581200 – volume: 295 start-page: R1941 issue: 6 year: 2008 ident: BFjhh201351_CR4 publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.90724.2008 – volume: 37 start-page: 72 issue: 1 year: 2001 ident: BFjhh201351_CR29 publication-title: Hypertension doi: 10.1161/01.HYP.37.1.72 – volume: 2 start-page: 403 issue: 5 Pt 1 year: 1989 ident: BFjhh201351_CR6 publication-title: Am JHypertens doi: 10.1093/ajh/2.5.403 – volume: 342 start-page: d1875 year: 2011 ident: BFjhh201351_CR10 publication-title: BMJ doi: 10.1136/bmj.d1875 – volume: 16 start-page: 853 issue: 6 year: 1998 ident: BFjhh201351_CR3 publication-title: J Hypertens doi: 10.1097/00004872-199816060-00017 – volume: 40 start-page: 511 issue: 4-6 year: 1991 ident: BFjhh201351_CR5 publication-title: J Steroid Biochem Mol Biol doi: 10.1016/0960-0760(91)90270-F – volume: 32 start-page: 956 issue: 12 year: 2011 ident: BFjhh201351_CR19 publication-title: Placenta doi: 10.1016/j.placenta.2011.09.020 – volume: 12 start-page: 642 issue: 6 year: 2006 ident: BFjhh201351_CR36 publication-title: Nat Med doi: 10.1038/nm1429 – volume: 8 start-page: 1676 issue: 6 year: 2009 ident: BFjhh201351_CR34 publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-09-0161 – volume: 4 start-page: 61 issue: 1 year: 2005 ident: BFjhh201351_CR26 publication-title: Autoimmun Rev doi: 10.1016/j.autrev.2004.07.002 – volume: 103 start-page: 945 issue: 7 year: 1999 ident: BFjhh201351_CR24 publication-title: J Clin Invest doi: 10.1172/JCI4106 – volume: 280 start-page: R994 issue: 4 year: 2001 ident: BFjhh201351_CR32 publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.2001.280.4.R994 – volume: 367 start-page: 1066 issue: 9516 year: 2006 ident: BFjhh201351_CR1 publication-title: Lancet doi: 10.1016/S0140-6736(06)68397-9 – volume: 33 start-page: 130 issue: 3 year: 2009 ident: BFjhh201351_CR2 publication-title: Semin Perinatol doi: 10.1053/j.semperi.2009.02.010 – volume: 290 start-page: 2945 issue: 22 year: 2003 ident: BFjhh201351_CR38 publication-title: JAMA doi: 10.1001/jama.290.22.2945 – volume: 91 start-page: 196 issue: 2 year: 1998 ident: BFjhh201351_CR14 publication-title: Obstet Gynecol doi: 10.1016/S0029-7844(97)00660-1 – volume: 2 start-page: 72 issue: 2 year: 2012 ident: BFjhh201351_CR8 publication-title: Pregnancy Hypertens doi: 10.1016/j.preghy.2012.01.001 – volume: 206 start-page: 136 issue: 1 year: 1970 ident: BFjhh201351_CR40 publication-title: Biochim Biophys Acta doi: 10.1016/0005-2744(70)90090-2 – volume: 82 start-page: 643 issue: 8 year: 1975 ident: BFjhh201351_CR16 publication-title: Br J Obstet Gynaecol doi: 10.1111/j.1471-0528.1975.tb00700.x – volume: 191 start-page: 1240 issue: 4 year: 2004 ident: BFjhh201351_CR37 publication-title: Am J Obst Gynecol doi: 10.1016/j.ajog.2004.03.004 – volume: 141 start-page: 55 issue: 1-3 year: 2007 ident: BFjhh201351_CR12 publication-title: Regul Pept doi: 10.1016/j.regpep.2006.12.014 – ident: BFjhh201351_CR7 doi: 10.1177/1470320313477174 – volume: 273 start-page: H2620 issue: 6 Pt 2 year: 1997 ident: BFjhh201351_CR27 publication-title: Am J Physiol – volume: 153 start-page: 485 issue: 3 year: 1966 ident: BFjhh201351_CR28 publication-title: J Pharmacol Exp Ther – volume: 24 start-page: 1261 issue: 6 year: 2012 ident: BFjhh201351_CR31 publication-title: Cell Signal doi: 10.1016/j.cellsig.2012.02.005 – volume: 40 start-page: 583 issue: 4 year: 2007 ident: BFjhh201351_CR17 publication-title: Braz J Med Biol Res doi: 10.1590/S0100-879X2007000400018 – volume: 107 start-page: 678 issue: 5 year: 2000 ident: BFjhh201351_CR22 publication-title: BJOG doi: 10.1111/j.1471-0528.2000.tb13312.x – volume: 93 start-page: 1049 issue: 10 year: 1986 ident: BFjhh201351_CR21 publication-title: Br J Obstet Gynaecol doi: 10.1111/j.1471-0528.1986.tb07830.x – volume: 82 start-page: 845 issue: 11 year: 2011 ident: BFjhh201351_CR39 publication-title: Ginekol Pol – volume: 8 start-page: 135 year: 2010 ident: BFjhh201351_CR9 publication-title: Reprod Biol Endocrinol doi: 10.1186/1477-7827-8-135 – volume: 18 start-page: 239 issue: 3 year: 2002 ident: BFjhh201351_CR15 publication-title: Endocrine doi: 10.1385/ENDO:18:3:239 – volume: 79 start-page: 403 issue: 4 year: 1990 ident: BFjhh201351_CR13 publication-title: Clin Sci (Lond) doi: 10.1042/cs0790403 – volume: 87 start-page: 36 issue: 2 year: 2012 ident: BFjhh201351_CR23 publication-title: Biol Reprod doi: 10.1095/biolreprod.112.099861 – volume: 188 start-page: 649 issue: 4 year: 2004 ident: BFjhh201351_CR30 publication-title: Bull Acad Natl Med – volume: 98 start-page: 155 issue: 2 year: 1991 ident: BFjhh201351_CR11 publication-title: Br J Obstet Gynaecol doi: 10.1111/j.1471-0528.1991.tb13361.x – volume: 27 start-page: 200 issue: 2-3 year: 2006 ident: BFjhh201351_CR20 publication-title: Placenta doi: 10.1016/j.placenta.2005.02.015 – reference: 21050477 - Reprod Biol Endocrinol. 2010 Nov 04;8:135 – reference: 11247819 - Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R994-R1000 – reference: 15652781 - Autoimmun Rev. 2005 Jan;4(1):61-5 – reference: 10826585 - BJOG. 2000 May;107(5):678-85 – reference: 15587684 - Bull Acad Natl Med. 2004;188(4):649-59; discussion 659 – reference: 22745921 - Pregnancy Hypertens. 2012 Apr 1;2(2):72-83 – reference: 9435595 - Am J Physiol. 1997 Dec;273(6 Pt 2):H2620-6 – reference: 18008188 - Endocrine. 2007 Oct;32(2):212-8 – reference: 10194466 - J Clin Invest. 1999 Apr;103(7):945-52 – reference: 17401503 - Braz J Med Biol Res. 2007 Apr;40(4):583-90 – reference: 21215447 - Placenta. 2011 Mar;32(3):214-21 – reference: 1180953 - Br J Obstet Gynaecol. 1975 Aug;82(8):643-50 – reference: 22374305 - Cell Signal. 2012 Jun;24(6):1261-9 – reference: 15507947 - Am J Obstet Gynecol. 2004 Oct;191(4):1240-6 – reference: 12450315 - Endocrine. 2002 Aug;18(3):239-45 – reference: 2171863 - Clin Sci (Lond). 1990 Oct;79(4):403-8 – reference: 22018415 - Placenta. 2011 Dec;32(12):956-62 – reference: 14665655 - JAMA. 2003 Dec 10;290(22):2945-51 – reference: 17291601 - Regul Pept. 2007 Jun 7;141(1-3):55-60 – reference: 19509262 - Mol Cancer Ther. 2009 Jun;8(6):1676-83 – reference: 4288411 - J Pharmacol Exp Ther. 1966 Sep;153(3):485-94 – reference: 11208759 - Hypertension. 2001 Jan;37(1):72-76 – reference: 21474517 - BMJ. 2011 Apr 07;342:d1875 – reference: 2004051 - Br J Obstet Gynaecol. 1991 Feb;98(2):155-61 – reference: 9663926 - J Hypertens. 1998 Jun;16(6):853-62 – reference: 9469275 - Obstet Gynecol. 1998 Feb;91(2):196-202 – reference: 19464502 - Semin Perinatol. 2009 Jun;33(3):130-7 – reference: 18971349 - Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1941-52 – reference: 19996068 - Hypertension. 2010 Feb;55(2):386-93 – reference: 23438673 - J Renin Angiotensin Aldosterone Syst. 2014 Dec;15(4):523-31 – reference: 16751767 - Nat Med. 2006 Jun;12 (6):642-9 – reference: 11815627 - J Biol Chem. 2002 Apr 26;277(17):14838-43 – reference: 22384618 - Ginekol Pol. 2011 Nov;82(11):845-50 – reference: 16581405 - Lancet. 2006 Apr 1;367(9516):1066-74 – reference: 3790464 - Br J Obstet Gynaecol. 1986 Oct;93(10):1049-59 – reference: 22649072 - Biol Reprod. 2012 Aug 23;87(2):36 – reference: 16338465 - Placenta. 2006 Feb-Mar;27(2-3):200-7 – reference: 4315054 - Biochim Biophys Acta. 1970 Apr 22;206(1):136-42 – reference: 2566314 - Am J Hypertens. 1989 May;2(5 Pt 1):403-10 – reference: 1958553 - J Steroid Biochem Mol Biol. 1991;40(4-6):511-5
SSID	ssj0014768
Score	2.2426515
Snippet	There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1–7) in the maternal circulation during pregnancy. To determine... There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1-7) in the maternal circulation during pregnancy. To determine...
SourceID	proquest gale pubmed crossref springer
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	133
SubjectTerms	631/443/494 631/443/592 692/699/75/243/793 Adult Angiotensin Angiotensin I - blood Angiotensin II Angiotensin II - blood Biomarkers - blood Blood Pressure Body mass index Case-Control Studies Development and progression Epidemiology Female Fetuses Gestation Gestational Age Health Administration Humans Hypertension Hypertension in pregnancy Hypertension, Pregnancy-Induced - blood Hypertension, Pregnancy-Induced - diagnosis Hypertension, Pregnancy-Induced - etiology Hypertension, Pregnancy-Induced - physiopathology Male Medicine Medicine & Public Health original-article Peptide Fragments - blood Peptidyl-Dipeptidase A - blood Plasma levels Pre-eclampsia Pre-Eclampsia - blood Pre-Eclampsia - diagnosis Pre-Eclampsia - etiology Pre-Eclampsia - physiopathology Preeclampsia Pregnancy Public Health Renin Renin - blood Renin-Angiotensin System Risk Assessment Risk Factors Sex Sex Determination Analysis Sex Factors Ultrasonography, Doppler Ultrasonography, Prenatal Young Adult
Title	Fetal sex and the circulating renin–angiotensin system during early gestation in women who later develop preeclampsia or gestational hypertension
URI	https://link.springer.com/article/10.1038/jhh.2013.51 https://www.ncbi.nlm.nih.gov/pubmed/23782994 https://www.proquest.com/docview/1475123526 https://www.proquest.com/docview/2640595214 https://www.proquest.com/docview/1490728669
Volume	28
WOSCitedRecordID	wos000329441300012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1476-5527 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0014768 issn: 0950-9240 databaseCode: M7P dateStart: 19970101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1476-5527 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0014768 issn: 0950-9240 databaseCode: 7X7 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-5527 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0014768 issn: 0950-9240 databaseCode: BENPR dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZoi1AvvCmBshipCAkpNIntODmhgrriwmqFQNpblNiT7iKULMkW-Bv8Y2Yc77ZbKi5ccvH4kcyM_TnzYuwIT4QS8roObQkqlKa2YVVH5PYHcVQLC1IPxSb0ZJLNZvnU_3DrvVvlek90G7VtDf0jP46lVhTXmaRvl99DqhpF1lVfQmOH7VGWBOFc96YbK4LULhQOUUQU4j0j8vF5kciOv87JEhGLNyreOpGu7suXDqYrllJ3AI3v_O_S77LbHnryk0FW7rEb0Nxntz564_oD9nsMiMR5D7942ViOyJCbRWdcfa_mjJNbXhOWzdmidV7vDR-yQPMh0pEDpUrmZK5yzOZI4NI78J_zluMY0HEfocWXHYBBUVz2i5K33UUnnH6OF-POTdA2D9mX8enn9x9CX7EhNEqmq7CSiU0yVYNKbQ1WiiqLaiMMmFJVdQ4KAU5W1pChEBgNKsfbXlSpSiREpHLxiO02bQOPGaebkQIEW1YlskpUid1Eai3CtyS2oAP2es21wvh05lRV41vhzOoiK5DFBbG4UHHAjjbEyyGLx_Vkz4n9xRCCutH94kRQxK7OtQrYK0dB2o-zmdIHMeCaKY_WFuXhFiVqrdluXstK4XeNvrgQlGubEbsiGEbtkgF7sWmmgclRroH2nIbII51kaZoH7GCQ3M0bJwLhYJ5j75drUb4099-f48m_1_iU7SOhHFzYD9nuqjuHZ-ym-bFa9N2I7eiZds9sxPbenU6mn0ZOO_8Af4pCPw
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELaqgoAL70egUCO1QkJKm9hxHgeEKmDVqu2KQ5H2FhJ70l2EkiXZUvgZ_BF-IzPOo91SceuBs8eP9c58MxPPg7EN1AgZJEXhmgyUG-jCuHnhUdgf-F4hDQRR22wiGo_jyST5uMJ-97kwFFbZY6IFalNp-ka-7QeRorxOEb6df3OpaxS9rvYtNFq22Iefp-iyNW_23uP_uynE6MPRu1236yrgahWECzcPhBGxKkCFpgATyDz2Ci016EzlRQIKlXCcFRDjQXUEKkGPxMtVLgURKSq-hJB_DXE8ohCyaDI4eHhEm3qHVovnol_jdfmAnoy3v0zp5cOXW8pf0oAX9cA5RXjhZdYqvNGd_-2q7rLbnWnNd1pZuMdWoLzPbhx2wQMP2K8RoKfBG_jBs9JwtHy5ntXa9i8rjzmFHZZuVh7PKhvVX_K2yjVvMzk5UCloTs9xlpk5EtjyFfx0WnFcA2reZaDxeQ2gUdTmzSzjVX02CbefouNf2w2q8iH7dCUX8oitllUJTxgnz08BGpNGiSAXKsNpMjQGzVPhG4gc9rrnklR35dqpa8jX1IYNyDhFlkqJpVLlO2xjIJ63VUouJ1sndkvbFNsB29IdSRnJURIph72yFIRuuJvOuiQNPDPVCVuiXFuiRFTSy8M9b6YdKjbpGWNeOoy2ORr7iB6Bw14Ow7QwBQKWUJ3QEokXiTgME4c9biVl-MVCormbJDh7sxedc3v_fR1P_33GdXZz9-jwID3YG-8_Y7dwUtCG66-x1UV9As_Zdf19MWvqFxYFOPt81bL0Bx6ZnyU
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELaqgiouvB-BQo3UCgkpbOLEeRwQqigrqsJqDyD1FhJ73F2EkpBsKf0Z_B1-HTNOsu2WilsPnD1-rHee8TczjG2jRcghNcbVOUg3VEa7hfEI9ge-ZwINYdw1m4gnk-TwMJ2usd9DLgzBKgedaBW1rhR9Ix_5YSwpr1NEI9PDIqZ74zf1d5c6SNFL69BOo2ORAzg9wfCtfb2_h__1jhDjd5_evnf7DgOukmG0cItQaJFIAzLSBnQYFIlnVKBA5bIwKUg0yEluIMFDqxhkitGJV8giEEQkqRATqv9rMRUtt7DB6fIFI4xtGh56MJ6LMY7X5wZ6QTL6OqNXED94Jf0Va3jRJpwzihdeaa3xG9_6n6_tNrvZu9x8t5ORO2wNyrts42MPKrjHfo0BIxDewk-el5qjR8zVvFG2r1l5xAmOWLp5eTSvLNq_5F31a95leHKgEtGcnuksk3MksGUt-Mms4rgGNLzPTON1A6BQBOt2nvOqOZuE289Oa2jsBlV5n32-kgt5wNbLqoRHjFNEKAGdTC1FWAiZ47Qg0hrdVuFriB32cuCYTPVl3KmbyLfMwgmCJEP2yoi9Muk7bHtJXHfVSy4n2yLWy7rU26XOy3YDylSO01g67IWlIK2Hu6m8T97AM1P9sBXKzRVK1FZqdXjg06zXlm12xqSXDqPPjkEAapXQYc-Xw7QwAQRLqI5pidSLRRJFqcMedlKz_MUiQDc4TXH2ziBG5_b--zoe__uMW2wDRSj7sD85eMJu4JywQ_FvsvVFcwxP2XX1YzFvm2dWIXD25apF6Q9zzqfz
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fetal+sex+and+the+circulating+renin-angiotensin+system+during+early+gestation+in+women+who+later+develop+preeclampsia+or+gestational+hypertension&rft.jtitle=Journal+of+human+hypertension&rft.au=Sykes%2C+S+D&rft.au=Pringle%2C+K+G&rft.au=Zhou%2C+A&rft.au=Dekker%2C+G+A&rft.date=2014-02-01&rft.pub=Nature+Publishing+Group&rft.issn=0950-9240&rft.eissn=1476-5527&rft.volume=28&rft.issue=2&rft.spage=133&rft_id=info:doi/10.1038%2Fjhh.2013.51&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=3175451971
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0950-9240&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0950-9240&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0950-9240&client=summon