Purifying stem cell‐derived red blood cells: a high‐throughput label‐free downstream processing strategy based on microfluidic spiral inertial separation and membrane filtration

Cell‐based therapeutics, such as in vitro manufactured red blood cells (mRBCs), are different to traditional biopharmaceutical products (the final product being the cells themselves as opposed to biological molecules such as proteins) and that presents a challenge of developing new robust and econom...

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Bibliographic Details
Published in:	Biotechnology and bioengineering Vol. 117; no. 7; pp. 2032 - 2045
Main Authors:	Guzniczak, Ewa, Otto, Oliver, Whyte, Graeme, Chandra, Tamir, Robertson, Neil A., Willoughby, Nik, Jimenez, Melanie, Bridle, Helen
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.07.2020 John Wiley and Sons Inc
Subjects:	Biopharmaceuticals CD34 antigen Cell Line Cell Separation - instrumentation Cord blood Deformability Equipment Design Erythrocytes Erythrocytes - cytology Erythropoiesis Filtration Filtration - instrumentation Fluorescence Formability Gene expression Humans Manufacturing industry Mechanical properties Membrane filtration Membranes Microfluidic Analytical Techniques - instrumentation Microfluidics Nuclei (cytology) Purification Purity Separation sorting spiral microchannel Stem cells Stem Cells - cytology stem cell‐derived red blood cells Umbilical cord deformability stem cell-derived red blood cells purification sorting spiral microchannel
ISSN:	0006-3592, 1097-0290, 1097-0290
Online Access:	Get full text
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