Gender-specific differences in the kinetics of nonfasting TRL, IDL, and LDL apolipoprotein B-100 in men and premenopausal women

To investigate mechanisms underlying gender differences in serum lipoprotein concentrations, the kinetic behavior of apoB-100 was assessed. Twenty subjects (<50 years; 12 men and 8 premenopausal women) were provided a Western diet for 4 to 6 weeks, after which the kinetics of apoB-100 in triglyce...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology Jg. 28; H. 10; S. 1838
Hauptverfasser:	Matthan, Nirupa R, Jalbert, Susan M, Barrett, P Hugh R, Dolnikowski, Gregory G, Schaefer, Ernst J, Lichtenstein, Alice H
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2008
Schlagworte:	Adult Apolipoprotein B-100 - blood Cardiovascular Diseases - blood Cardiovascular Diseases - etiology Cholesterol - blood Female Humans Kinetics Lipoproteins - blood Lipoproteins, IDL - blood Lipoproteins, LDL - blood Male Models, Biological Postprandial Period Premenopause - metabolism Risk Factors Sex Factors Triglycerides - blood
ISSN:	1524-4636, 1524-4636
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	To investigate mechanisms underlying gender differences in serum lipoprotein concentrations, the kinetic behavior of apoB-100 was assessed. Twenty subjects (<50 years; 12 men and 8 premenopausal women) were provided a Western diet for 4 to 6 weeks, after which the kinetics of apoB-100 in triglyceride-rich, intermediate-density, and low-density lipoprotein (TRL, IDL, and LDL) were determined in the fed state. Nonfasting plasma TC, LDL-C, and triglyceride concentrations were 23%, 34%, and 57% lower, respectively, in the women compared with men. Plasma TRL and LDL apoB 100 pool sizes were lower by 40% and 30%, respectively. These differences were accounted for by higher TRL and LDL apoB 100 fractional catabolic rates (FCR), rather than differences in production rates (PR). Plasma TRL-C and LDL-C were positively correlated with TRL and LDL apoB 100 concentrations and pool size, and negatively correlated with TRL and LDL apoB 100 FCR (women: r=-0.59, P<0.01 and r=-0.54, P<0.04, and men: r=-0.43, P<0.05 and r=-0.44, P<0.05). No significant associations were observed between plasma TRL-C and LDL-C and PR. These data suggest the mechanism for lower TRL-C and LDL-C concentrations in women was determined predominantly by higher TRL and LDL FCR rather than lower PR. This could explain, in part, the lower CVD risk in premenopausal women relative to men.
AbstractList	To investigate mechanisms underlying gender differences in serum lipoprotein concentrations, the kinetic behavior of apoB-100 was assessed. Twenty subjects (<50 years; 12 men and 8 premenopausal women) were provided a Western diet for 4 to 6 weeks, after which the kinetics of apoB-100 in triglyceride-rich, intermediate-density, and low-density lipoprotein (TRL, IDL, and LDL) were determined in the fed state. Nonfasting plasma TC, LDL-C, and triglyceride concentrations were 23%, 34%, and 57% lower, respectively, in the women compared with men. Plasma TRL and LDL apoB 100 pool sizes were lower by 40% and 30%, respectively. These differences were accounted for by higher TRL and LDL apoB 100 fractional catabolic rates (FCR), rather than differences in production rates (PR). Plasma TRL-C and LDL-C were positively correlated with TRL and LDL apoB 100 concentrations and pool size, and negatively correlated with TRL and LDL apoB 100 FCR (women: r=-0.59, P<0.01 and r=-0.54, P<0.04, and men: r=-0.43, P<0.05 and r=-0.44, P<0.05). No significant associations were observed between plasma TRL-C and LDL-C and PR. These data suggest the mechanism for lower TRL-C and LDL-C concentrations in women was determined predominantly by higher TRL and LDL FCR rather than lower PR. This could explain, in part, the lower CVD risk in premenopausal women relative to men. To investigate mechanisms underlying gender differences in serum lipoprotein concentrations, the kinetic behavior of apoB-100 was assessed.OBJECTIVETo investigate mechanisms underlying gender differences in serum lipoprotein concentrations, the kinetic behavior of apoB-100 was assessed.Twenty subjects (<50 years; 12 men and 8 premenopausal women) were provided a Western diet for 4 to 6 weeks, after which the kinetics of apoB-100 in triglyceride-rich, intermediate-density, and low-density lipoprotein (TRL, IDL, and LDL) were determined in the fed state. Nonfasting plasma TC, LDL-C, and triglyceride concentrations were 23%, 34%, and 57% lower, respectively, in the women compared with men. Plasma TRL and LDL apoB 100 pool sizes were lower by 40% and 30%, respectively. These differences were accounted for by higher TRL and LDL apoB 100 fractional catabolic rates (FCR), rather than differences in production rates (PR). Plasma TRL-C and LDL-C were positively correlated with TRL and LDL apoB 100 concentrations and pool size, and negatively correlated with TRL and LDL apoB 100 FCR (women: r=-0.59, P<0.01 and r=-0.54, P<0.04, and men: r=-0.43, P<0.05 and r=-0.44, P<0.05). No significant associations were observed between plasma TRL-C and LDL-C and PR.METHODS AND RESULTSTwenty subjects (<50 years; 12 men and 8 premenopausal women) were provided a Western diet for 4 to 6 weeks, after which the kinetics of apoB-100 in triglyceride-rich, intermediate-density, and low-density lipoprotein (TRL, IDL, and LDL) were determined in the fed state. Nonfasting plasma TC, LDL-C, and triglyceride concentrations were 23%, 34%, and 57% lower, respectively, in the women compared with men. Plasma TRL and LDL apoB 100 pool sizes were lower by 40% and 30%, respectively. These differences were accounted for by higher TRL and LDL apoB 100 fractional catabolic rates (FCR), rather than differences in production rates (PR). Plasma TRL-C and LDL-C were positively correlated with TRL and LDL apoB 100 concentrations and pool size, and negatively correlated with TRL and LDL apoB 100 FCR (women: r=-0.59, P<0.01 and r=-0.54, P<0.04, and men: r=-0.43, P<0.05 and r=-0.44, P<0.05). No significant associations were observed between plasma TRL-C and LDL-C and PR.These data suggest the mechanism for lower TRL-C and LDL-C concentrations in women was determined predominantly by higher TRL and LDL FCR rather than lower PR. This could explain, in part, the lower CVD risk in premenopausal women relative to men.CONCLUSIONSThese data suggest the mechanism for lower TRL-C and LDL-C concentrations in women was determined predominantly by higher TRL and LDL FCR rather than lower PR. This could explain, in part, the lower CVD risk in premenopausal women relative to men.
Author	Barrett, P Hugh R Schaefer, Ernst J Matthan, Nirupa R Dolnikowski, Gregory G Lichtenstein, Alice H Jalbert, Susan M
Author_xml	– sequence: 1 givenname: Nirupa R surname: Matthan fullname: Matthan, Nirupa R email: nirupa.matthan@tufts.edu organization: Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. nirupa.matthan@tufts.edu – sequence: 2 givenname: Susan M surname: Jalbert fullname: Jalbert, Susan M – sequence: 3 givenname: P Hugh R surname: Barrett fullname: Barrett, P Hugh R – sequence: 4 givenname: Gregory G surname: Dolnikowski fullname: Dolnikowski, Gregory G – sequence: 5 givenname: Ernst J surname: Schaefer fullname: Schaefer, Ernst J – sequence: 6 givenname: Alice H surname: Lichtenstein fullname: Lichtenstein, Alice H
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18658047$$D View this record in MEDLINE/PubMed
BookMark	eNpNkEtLxDAUhYOMOA_9Ay4kK1d2TNIkbZfz0JmBgiCj25KmNxpt09q0iCv_ulVHcHPvOfDdw-FO0cjVDhA6p2ROqaTXi_3jcrFdzCmJ51SGSUiP0IQKxgMuQzn6p8do6v0LIYQzRk7QmMZSxIRHE_S5AVdAG_gGtDVW48IaAy04DR5bh7tnwK_WQWe1x7XBQwWjfGfdE97fp1d4tx6GcgVO1ylWTV3apm7auoPhdhlQQr5DKnA_TNPCIOtG9V6V-L0ezCk6Nqr0cHbYM_Rwe7NfbYP0brNbLdJACy5FwEDEKjQREVIWBePAQxUTIw2nkkUyURHkOqGaMykFzWMhNNWM5iQXCdeMsxm6_M0dyr314Lussl5DWSoHde8zmYiYcR4P4MUB7PMKiqxpbaXaj-zvZewLTwpvBw
CitedBy_id	crossref_primary_10_1017_S000711451200534X crossref_primary_10_3389_fcvm_2021_707889 crossref_primary_10_1016_j_atherosclerosis_2017_08_014 crossref_primary_10_1016_j_ogc_2009_03_001 crossref_primary_10_3390_ph17070913 crossref_primary_10_1007_s10557_021_07273_0 crossref_primary_10_1111_j_1365_2362_2011_02591_x crossref_primary_10_1161_ATVBAHA_120_315260 crossref_primary_10_3390_ijms252011237 crossref_primary_10_1089_met_2018_0067 crossref_primary_10_1210_jc_2010_2061 crossref_primary_10_3389_fendo_2014_00162 crossref_primary_10_3389_fmed_2024_1458025 crossref_primary_10_1016_j_jlr_2024_100526 crossref_primary_10_1017_S0007114521002671 crossref_primary_10_1177_20420188231199359 crossref_primary_10_3390_jcm8010098 crossref_primary_10_3390_ph16060853 crossref_primary_10_3168_jds_2010_3311 crossref_primary_10_1016_j_molmet_2018_05_008 crossref_primary_10_1016_j_ajhg_2012_08_032 crossref_primary_10_1194_jlr_P024315 crossref_primary_10_7717_peerj_19883 crossref_primary_10_1093_infdis_jiv310 crossref_primary_10_3389_fphys_2019_01486 crossref_primary_10_1007_s00059_020_04911_5 crossref_primary_10_3390_nu13124339 crossref_primary_10_3390_metabo11100690 crossref_primary_10_1126_scitranslmed_aaw7905 crossref_primary_10_1097_MD_0000000000019535 crossref_primary_10_1186_s12917_017_1152_y crossref_primary_10_3389_fnut_2023_1020678 crossref_primary_10_1186_s12889_020_09011_x crossref_primary_10_3390_cells10092502 crossref_primary_10_3390_nu15081865 crossref_primary_10_1017_S1368980014002122 crossref_primary_10_1161_ATVBAHA_123_318980 crossref_primary_10_1007_s11745_010_3513_1 crossref_primary_10_1210_jc_2011_1251
ContentType	Journal Article
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1161/ATVBAHA.108.163931
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Medicine
EISSN	1524-4636
ExternalDocumentID	18658047
Genre	Comparative Study Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NHLBI NIH HHS grantid: HL 39236 – fundername: NHLBI NIH HHS grantid: R01 HL054727 – fundername: NIBIB NIH HHS grantid: P41 EB-001975 – fundername: NIBIB NIH HHS grantid: P41 EB001975 – fundername: NHLBI NIH HHS grantid: HL 54727
GroupedDBID	--- .3C .55 .GJ .Z2 01R 0R~ 1J1 23N 2WC 3O- 40H 4Q1 4Q2 4Q3 53G 5GY 5RE 5VS 71W 77Y 7O~ AAAAV AAAXR AAGIX AAHPQ AAIQE AAMOA AAMTA AAQKA AARTV AASCR AASOK AAXQO ABASU ABBUW ABDIG ABJNI ABPXF ABQRW ABVCZ ABXVJ ABZAD ABZZY ACCJW ACDDN ACEWG ACGFS ACGOD ACILI ACLDA ACPRK ACWDW ACWRI ACXJB ACXNZ ACZKN ADBBV ADFPA ADGGA ADGHP ADHPY ADNKB AE3 AE6 AEETU AENEX AFBFQ AFDTB AFFNX AFUWQ AGINI AHJKT AHMBA AHOMT AHQNM AHRYX AHVBC AIJEX AINUH AJCLO AJIOK AJNWD AJNYG AJZMW AKCTQ AKULP ALKUP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AOQMC AYCSE BAWUL BOYCO BQLVK BS7 C1A C45 CGR CS3 CUY CVF DIK DIWNM DUNZO E.X E3Z EBS ECM EEVPB EIF EJD ERAAH EX3 F2K F2L F2M F2N F5P FCALG FL- FRP FW0 GNXGY GQDEL GX1 H0~ H13 HLJTE HZ~ IKREB IKYAY IN~ IPNFZ J5H JF9 JG8 JK3 JK8 K8S KD2 KMI KQ8 L-C L7B N9A NPM N~7 N~B N~M O9- OAG OAH OB2 OCUKA ODA OL1 OLG OLH OLU OLV OLY OLZ OPUJH ORVUJ OUVQU OVD OVDNE OVIDH OVLEI OWU OWV OWW OWX OWY OWZ OXXIT P-K P2P PQQKQ PZZ RAH RIG RLZ S4R S4S T8P TEORI TR2 TSPGW V2I VVN W3M W8F WOQ WOW X3V X3W X7M XXN XYM YFH ZGI ZZMQN 7X8 ADKSD
ID	FETCH-LOGICAL-c5465-2e58a3f70566dd24e43a80f6f4162769a7ebc91c426651b855c1c21b0b594c242
IEDL.DBID	7X8
ISICitedReferencesCount	44
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000259278200025&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1524-4636
IngestDate	Sat Sep 27 20:14:35 EDT 2025 Mon Jul 21 05:36:58 EDT 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	10
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c5465-2e58a3f70566dd24e43a80f6f4162769a7ebc91c426651b855c1c21b0b594c242
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
OpenAccessLink	https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.108.163931
PMID	18658047
PQID	69582448
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_69582448 pubmed_primary_18658047
PublicationCentury	2000
PublicationDate	2008-October
PublicationDateYYYYMMDD	2008-10-01
PublicationDate_xml	– month: 10 year: 2008 text: 2008-October
PublicationDecade	2000
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Arteriosclerosis, thrombosis, and vascular biology
PublicationTitleAlternate	Arterioscler Thromb Vasc Biol
PublicationYear	2008
SSID	ssj0004220
Score	2.1492739
Snippet	To investigate mechanisms underlying gender differences in serum lipoprotein concentrations, the kinetic behavior of apoB-100 was assessed. Twenty subjects... To investigate mechanisms underlying gender differences in serum lipoprotein concentrations, the kinetic behavior of apoB-100 was assessed.OBJECTIVETo...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	1838
SubjectTerms	Adult Apolipoprotein B-100 - blood Cardiovascular Diseases - blood Cardiovascular Diseases - etiology Cholesterol - blood Female Humans Kinetics Lipoproteins - blood Lipoproteins, IDL - blood Lipoproteins, LDL - blood Male Models, Biological Postprandial Period Premenopause - metabolism Risk Factors Sex Factors Triglycerides - blood
Title	Gender-specific differences in the kinetics of nonfasting TRL, IDL, and LDL apolipoprotein B-100 in men and premenopausal women
URI	https://www.ncbi.nlm.nih.gov/pubmed/18658047 https://www.proquest.com/docview/69582448
Volume	28
WOSCitedRecordID	wos000259278200025&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LSwMxEA5qRbz4fr9y8GjsZjfZ3YAg9YVCW4rU0lvJJlkQcbda69W_7ky6Cx4ED15ySkLIzs58SWa-j5DTyHFhbBSxHDPbRRhELANkwEKbKWWtjFNfCzNoJ91uOhyq3hy5qGthMK2y9oneUdvS4B15M1YyhVCUXo7fGGpG4dtqJaAxTxoRABm06WT4gys89KSMEKAEQ1qsumQm5s1Wf3DVum9hgt05ABJVScz9CjB9oLlb_d8S18hKBTBpa2YR62TOFRtkqVM9oW-Sr5l4HMMSS0wTorVECjgM-lxQAIT0BXoifTMtc1qURa4nmBxN-4_tM_pwA40uLG3ftKlGjYdx6ckeYOwVuNsAJ3l1he8z9rePcC6fTmBNnu1hizzd3fav71mlwsAMCqWz0MlUR3kCSCm2NhRORDoN8jgHKBcmsdKJy4ziBkO95FkqpeEm5FmQSSUMIIBtsgBLdbuE4uFSZEJHQmphhVZxYnIYk0gN83C3R07qjR2BlePThS5cOZ2M6q3dIzuzbzMaz8g4RjwFDBWIZP_PsQdkOazJbPkhaeTwf7sjsmg-P54n78feeKDt9jrf5tbMMw
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Gender-specific+differences+in+the+kinetics+of+nonfasting+TRL%2C+IDL%2C+and+LDL+apolipoprotein+B-100+in+men+and+premenopausal+women&rft.jtitle=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.au=Matthan%2C+Nirupa+R&rft.au=Jalbert%2C+Susan+M&rft.au=Barrett%2C+P+Hugh+R&rft.au=Dolnikowski%2C+Gregory+G&rft.date=2008-10-01&rft.eissn=1524-4636&rft.volume=28&rft.issue=10&rft.spage=1838&rft_id=info:doi/10.1161%2FATVBAHA.108.163931&rft_id=info%3Apmid%2F18658047&rft_id=info%3Apmid%2F18658047&rft.externalDocID=18658047
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1524-4636&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1524-4636&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1524-4636&client=summon