Matrix metalloproteinase-9 is increased in obese subjects and decreases in response to pioglitazone

The study investigated the regulation of matrix metalloproteinases (MMP)-9 in obesity-associated insulin resistance in humans. The objectives of the investigation were to study MMP-9 regulation by insulin resistance and pioglitazone treatment in impaired glucose tolerant subjects using adipose tissu...

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Bibliographic Details
Published in:	The journal of clinical endocrinology and metabolism Vol. 95; no. 6; p. 2993
Main Authors:	Unal, Resat, Yao-Borengasser, Aiwei, Varma, Vijayalakshmi, Rasouli, Neda, Labbate, Craig, Kern, Philip A, Ranganathan, Gouri
Format:	Journal Article
Language:	English
Published:	United States 01.06.2010
Subjects:	Adipocytes - drug effects Adipocytes - enzymology Adipose Tissue - enzymology Adult Aged Blotting, Western Body Mass Index Cells, Cultured Coculture Techniques Female Humans Hypoglycemic Agents - therapeutic use Insulin Resistance Male Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors Middle Aged Obesity - enzymology Oligonucleotides - metabolism Pioglitazone Protein Kinase C-alpha - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA - biosynthesis RNA - genetics Stromal Cells - drug effects Stromal Cells - enzymology Th1 Cells - drug effects Th1 Cells - enzymology Thiazolidinediones - therapeutic use Transfection Young Adult
ISSN:	1945-7197, 1945-7197
Online Access:	Get more information
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