P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition

Chronic neurodegeneration in survivors of traumatic brain injury (TBI) is a major cause of morbidity, with no effective therapies to mitigate this progressive and debilitating form of nerve cell death. Here, we report that pharmacologic restoration of the blood-brain barrier (BBB), 12 mo after murin...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 44; p. 27667
Main Authors:	Vázquez-Rosa, Edwin, Shin, Min-Kyoo, Dhar, Matasha, Chaubey, Kalyani, Cintrón-Pérez, Coral J, Tang, Xinmiao, Liao, Xudong, Miller, Emiko, Koh, Yeojung, Barker, Sarah, Franke, Kathryn, Crosby, Danyel R, Schroeder, Rachel, Emery, Josie, Yin, Terry C, Fujioka, Hisashi, Reynolds, James D, Harper, Matthew M, Jain, Mukesh K, Pieper, Andrew A
Format:	Journal Article
Language:	English
Published:	United States 03.11.2020
Subjects:	Animals Behavior, Animal - drug effects Behavior, Animal - physiology Blood-Brain Barrier - cytology Blood-Brain Barrier - drug effects Blood-Brain Barrier - pathology Blood-Brain Barrier - ultrastructure Brain Injuries, Traumatic - complications Brain Injuries, Traumatic - drug therapy Brain Injuries, Traumatic - pathology Carbazoles - pharmacology Carbazoles - therapeutic use Cells, Cultured Chronic Disease - drug therapy Cognition - drug effects Cognition - physiology Disease Models, Animal Endothelial Cells Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Humans Male Mice Microscopy, Electron Microvessels - cytology Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - etiology Neurodegenerative Diseases - pathology Neurodegenerative Diseases - physiopathology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Primary Cell Culture Survivors neurodegeneration traumatic brain injury blood–brain barrier inflammation neuroprotection
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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