A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer

The primary aim of our study was to evaluate the safety and potential toxicity of gemcitabine combined with microbubbles under sonication in inoperable pancreatic cancer patients. The secondary aim was to evaluate a novel image-guided microbubble-based therapy, based on commercially available techno...

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Bibliographic Details
Published in:	Journal of controlled release Vol. 243; pp. 172 - 181
Main Authors:	Dimcevski, Georg, Kotopoulis, Spiros, Bjånes, Tormod, Hoem, Dag, Schjøtt, Jan, Gjertsen, Bjørn Tore, Biermann, Martin, Molven, Anders, Sorbye, Halfdan, McCormack, Emmet, Postema, Michiel, Gilja, Odd Helge
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 10.12.2016 Elsevier
Subjects:	adenocarcinoma adverse effects Aged Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - therapeutic use Bioengineering Cancer Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - therapy Clinical trial clinical trials Combined Modality Therapy Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Female Human health and pathology Humans Hépatology and Gastroenterology Image-guided therapy Imaging Infusions, Intravenous intravenous injection Life Sciences Male Microbubbles Microbubbles - therapeutic use Middle Aged Pancreatic cancer pancreatic neoplasms Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy patients Pharmaceutical sciences Pharmacology quality of life Sonoporation Survival Rate t-test toxicity Treatment Outcome Ultrasonic Therapy - methods ultrasonic treatment Ultrasound Microbubbles Clinical trial Image-guided therapy Ultrasound Sonoporation Pancreatic cancer
ISSN:	0168-3659, 1873-4995, 1873-4995
Online Access:	Get full text
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