Phosphoinositide 5- and 3-phosphatase activities of a voltage-sensing phosphatase in living cells show identical voltage dependence

Voltage-sensing phosphatases (VSPs) are homologs of phosphatase and tensin homolog (PTEN), a phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] 3-phosphatase. However, VSPs have a wider range of substrates, cleaving 3-phosphate from PI(3,4)P2...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 26; p. E3686
Main Authors:	Keum, Dongil, Kruse, Martin, Kim, Dong-Il, Hille, Bertil, Suh, Byung-Chang
Format:	Journal Article
Language:	English
Published:	United States 28.06.2016
Subjects:	Fluorescence Resonance Energy Transfer Humans Kinetics Phosphatidylinositol Phosphates - chemistry Phosphatidylinositol Phosphates - metabolism Phosphoric Monoester Hydrolases - chemistry Phosphoric Monoester Hydrolases - metabolism PTEN Phosphohydrolase - chemistry PTEN Phosphohydrolase - metabolism Substrate Specificity Dr-VSP Ci-VSP PI(3,4,5)P3 phosphoinositide PI(4,5)P2
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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