Differential RelA- and RelB-dependent gene transcription in LTβR-stimulated mouse embryonic fibroblasts
Background Lymphotoxin signaling via the lymphotoxin-β receptor (LTβR) has been implicated in biological processes ranging from development of secondary lymphoid organs, maintenance of spleen architecture, host defense against pathogens, autoimmunity, and lipid homeostasis. The major transcription f...
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| Veröffentlicht in: | BMC genomics Jg. 9; H. 1; S. 606 |
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| Sprache: | Englisch |
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| Abstract | Background
Lymphotoxin signaling via the lymphotoxin-β receptor (LTβR) has been implicated in biological processes ranging from development of secondary lymphoid organs, maintenance of spleen architecture, host defense against pathogens, autoimmunity, and lipid homeostasis. The major transcription factor that is activated by LTβR crosslinking is NF-κB. Two signaling pathways have been described, the classical inhibitor of NF-κB α (IκBα)-regulated and the alternative p100-regulated pathway that result in the activation of p50-RelA and p52-RelB NF-κB heterodimers, respectively.
Results
Using microarray analysis, we investigated the transcriptional response downstream of the LTβR in mouse embryonic fibroblasts (MEFs) and its regulation by the RelA and RelB subunits of NF-κB. We describe novel LTβR-responsive genes that were regulated by RelA and/or RelB. The majority of LTβR-regulated genes required the presence of both RelA and RelB, revealing significant crosstalk between the two NF-κB activation pathways. Gene Ontology (GO) analysis confirmed that LTβR-NF-κB target genes are predominantly involved in the regulation of immune responses. However, other biological processes, such as apoptosis/cell death, cell cycle, angiogenesis, and taxis were also regulated by LTβR signaling. Moreover, LTβR activation inhibited expression of a key adipogenic transcription factor, peroxisome proliferator activated receptor-γ (
pparg
), suggesting that LTβR signaling may interfere with adipogenic differentiation.
Conclusion
Microarray analysis of LTβR-stimulated fibroblasts provided comprehensive insight into the transcriptional response of LTβR signaling and its regulation by the NF-κB family members RelA and RelB. |
|---|---|
| AbstractList | Abstract Background Lymphotoxin signaling via the lymphotoxin-β receptor (LTβR) has been implicated in biological processes ranging from development of secondary lymphoid organs, maintenance of spleen architecture, host defense against pathogens, autoimmunity, and lipid homeostasis. The major transcription factor that is activated by LTβR crosslinking is NF-κB. Two signaling pathways have been described, the classical inhibitor of NF-κB α (IκBα)-regulated and the alternative p100-regulated pathway that result in the activation of p50-RelA and p52-RelB NF-κB heterodimers, respectively. Results Using microarray analysis, we investigated the transcriptional response downstream of the LTβR in mouse embryonic fibroblasts (MEFs) and its regulation by the RelA and RelB subunits of NF-κB. We describe novel LTβR-responsive genes that were regulated by RelA and/or RelB. The majority of LTβR-regulated genes required the presence of both RelA and RelB, revealing significant crosstalk between the two NF-κB activation pathways. Gene Ontology (GO) analysis confirmed that LTβR-NF-κB target genes are predominantly involved in the regulation of immune responses. However, other biological processes, such as apoptosis/cell death, cell cycle, angiogenesis, and taxis were also regulated by LTβR signaling. Moreover, LTβR activation inhibited expression of a key adipogenic transcription factor, peroxisome proliferator activated receptor-γ (pparg), suggesting that LTβR signaling may interfere with adipogenic differentiation. Conclusion Microarray analysis of LTβR-stimulated fibroblasts provided comprehensive insight into the transcriptional response of LTβR signaling and its regulation by the NF-κB family members RelA and RelB. Background Lymphotoxin signaling via the lymphotoxin-β receptor (LTβR) has been implicated in biological processes ranging from development of secondary lymphoid organs, maintenance of spleen architecture, host defense against pathogens, autoimmunity, and lipid homeostasis. The major transcription factor that is activated by LTβR crosslinking is NF-κB. Two signaling pathways have been described, the classical inhibitor of NF-κB α (IκBα)-regulated and the alternative p100-regulated pathway that result in the activation of p50-RelA and p52-RelB NF-κB heterodimers, respectively. Results Using microarray analysis, we investigated the transcriptional response downstream of the LTβR in mouse embryonic fibroblasts (MEFs) and its regulation by the RelA and RelB subunits of NF-κB. We describe novel LTβR-responsive genes that were regulated by RelA and/or RelB. The majority of LTβR-regulated genes required the presence of both RelA and RelB, revealing significant crosstalk between the two NF-κB activation pathways. Gene Ontology (GO) analysis confirmed that LTβR-NF-κB target genes are predominantly involved in the regulation of immune responses. However, other biological processes, such as apoptosis/cell death, cell cycle, angiogenesis, and taxis were also regulated by LTβR signaling. Moreover, LTβR activation inhibited expression of a key adipogenic transcription factor, peroxisome proliferator activated receptor-γ ( pparg ), suggesting that LTβR signaling may interfere with adipogenic differentiation. Conclusion Microarray analysis of LTβR-stimulated fibroblasts provided comprehensive insight into the transcriptional response of LTβR signaling and its regulation by the NF-κB family members RelA and RelB. |
| ArticleNumber | 606 |
| Audience | Academic |
| Author | Möller, Ulrich Radke, Dörte Habenicht, Andreas JR Weih, Falk Lovas, Agnes Yilmaz, Z Buket Albrecht, Daniela |
| AuthorAffiliation | 2 Bioinformatics – Pattern Recognition, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Beutenbergstrasse 11a, 07745 Jena, Germany 6 Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, Walther Rathenau Strasse 48, 17475 Greifswald, Germany 5 Institute for Vascular Medicine, Friedrich Schiller University of Jena, Bachstrasse 18, 07743 Jena, Germany 1 Research Group Immunology, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany 4 Signal Transduction in Tumor Cells, Max Delbrück Center for Molecular Medicine, Robert Rössle Strasse 10, 13092 Berlin-Buch, Germany 3 Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Beutenbergstrasse 11a, 07745 Jena, Germany |
| AuthorAffiliation_xml | – name: 1 Research Group Immunology, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany – name: 6 Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, Walther Rathenau Strasse 48, 17475 Greifswald, Germany – name: 3 Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Beutenbergstrasse 11a, 07745 Jena, Germany – name: 5 Institute for Vascular Medicine, Friedrich Schiller University of Jena, Bachstrasse 18, 07743 Jena, Germany – name: 4 Signal Transduction in Tumor Cells, Max Delbrück Center for Molecular Medicine, Robert Rössle Strasse 10, 13092 Berlin-Buch, Germany – name: 2 Bioinformatics – Pattern Recognition, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Beutenbergstrasse 11a, 07745 Jena, Germany |
| Author_xml | – sequence: 1 givenname: Agnes surname: Lovas fullname: Lovas, Agnes organization: Research Group Immunology, Leibniz Institute for Age Research, Fritz Lipmann Institute – sequence: 2 givenname: Dörte surname: Radke fullname: Radke, Dörte organization: Bioinformatics – Pattern Recognition, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Institute for Vascular Medicine, Friedrich Schiller University of Jena, Institute for Community Medicine, Ernst Moritz Arndt University Greifswald – sequence: 3 givenname: Daniela surname: Albrecht fullname: Albrecht, Daniela organization: Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute – sequence: 4 givenname: Z Buket surname: Yilmaz fullname: Yilmaz, Z Buket organization: Research Group Immunology, Leibniz Institute for Age Research, Fritz Lipmann Institute, Signal Transduction in Tumor Cells, Max Delbrück Center for Molecular Medicine – sequence: 5 givenname: Ulrich surname: Möller fullname: Möller, Ulrich organization: Bioinformatics – Pattern Recognition, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute – sequence: 6 givenname: Andreas JR surname: Habenicht fullname: Habenicht, Andreas JR organization: Institute for Vascular Medicine, Friedrich Schiller University of Jena – sequence: 7 givenname: Falk surname: Weih fullname: Weih, Falk email: fweih@fli-leibniz.de organization: Research Group Immunology, Leibniz Institute for Age Research, Fritz Lipmann Institute |
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| Cites_doi | 10.1038/ncb942 10.4049/jimmunol.167.4.1909 10.1016/j.cell.2008.01.020 10.1074/jbc.M210768200 10.1126/science.1137221 10.1016/S0092-8674(02)00703-1 10.1016/j.bcp.2006.08.007 10.1074/jbc.M300106200 10.1038/sj.onc.1209933 10.4049/jimmunol.168.10.5079 10.1016/S1097-2765(00)80210-5 10.1101/gad.1228704 10.1016/j.immuni.2005.10.002 10.1016/S1097-2765(03)00227-2 10.1016/j.imbio.2007.10.011 10.1038/sj.onc.1204868 10.1016/0092-8674(95)90416-6 10.1074/jbc.M701642200 10.1111/j.2517-6161.1995.tb02031.x 10.1093/emboj/cdg004 10.1158/0008-5472.CAN-06-0217 10.1093/nar/17.15.6419 10.1034/j.1600-065X.2003.00064.x 10.1016/S1074-7613(02)00423-5 10.1006/excr.2002.5573 10.1038/sj.emboj.7600391 10.1016/j.it.2004.03.008 10.1016/j.cell.2006.12.033 10.1128/MCB.01469-07 10.1038/nri1054 10.1002/jlb.67.4.577 10.1016/j.cytogfr.2008.04.005 10.1128/MCB.25.6.2130-2137.2005 10.4049/jimmunol.174.9.5526 10.1038/ni1573 10.1038/376167a0 10.1111/j.0105-2896.2004.00206.x 10.4049/jimmunol.175.2.1295 10.1146/annurev.immunol.23.021704.115719 |
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| Copyright | Lovas et al; licensee BioMed Central Ltd. 2008 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. COPYRIGHT 2008 BioMed Central Ltd. Copyright © 2008 Lovas et al; licensee BioMed Central Ltd. 2008 Lovas et al; licensee BioMed Central Ltd. |
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| Keywords | Hepatic Lipase Enrich Biological Process Motif Ligand Gene Ontology Adipogenic Differentiation |
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| References | S Basak (1799_CR13) 2008; 28 S Basak (1799_CR14) 2008; 19 K Schneider (1799_CR16) 2004; 202 N Kubota (1799_CR35) 1999; 4 H Kanda (1799_CR29) 2008; 9 S Saccani (1799_CR25) 2003; 11 E Dejardin (1799_CR5) 2002; 17 CF Ware (1799_CR17) 2005; 23 YS Kim (1799_CR24) 2005; 25 C Huber (1799_CR27) 2005; 174 M Suzawa (1799_CR36) 2003; 5 M Lukashev (1799_CR34) 2006; 66 A Hoffmann (1799_CR4) 2006; 25 F Weih (1799_CR37) 1994; 9 Y Benjamini (1799_CR39) 1995; 57 E Derudder (1799_CR6) 2003; 278 S Ghosh (1799_CR1) 2002; 109 JL Browning (1799_CR30) 2005; 23 E Dejardin (1799_CR11) 2006; 72 GE Garcia (1799_CR32) 2000; 67 J Barlic (1799_CR33) 2007; 282 AA Beg (1799_CR18) 1995; 376 S Basak (1799_CR12) 2007; 128 G Bonizzi (1799_CR31) 2004; 23 S Kutsch (1799_CR41) 2008; 213 ZB Yilmaz (1799_CR9) 2003; 22 RA Anders (1799_CR21) 2005; 175 S Rozen (1799_CR40) 2000; 132 JC Lo (1799_CR22) 2007; 316 MS Hayden (1799_CR2) 2004; 18 YH Chang (1799_CR23) 2002; 278 GD Bren (1799_CR26) 2001; 20 G Bonizzi (1799_CR10) 2004; 25 F Weih (1799_CR8) 2003; 195 RE Mebius (1799_CR15) 2003; 3 MS Hayden (1799_CR3) 2008; 132 DS Weih (1799_CR20) 2001; 167 JR Muller (1799_CR7) 2003; 278 JL Browning (1799_CR28) 2002; 168 E Schreiber (1799_CR38) 1989; 17 F Weih (1799_CR19) 1995; 80 |
| References_xml | – volume: 5 start-page: 224 year: 2003 ident: 1799_CR36 publication-title: Nat Cell Biol doi: 10.1038/ncb942 – volume: 167 start-page: 1909 year: 2001 ident: 1799_CR20 publication-title: J Immunol doi: 10.4049/jimmunol.167.4.1909 – volume: 132 start-page: 344 year: 2008 ident: 1799_CR3 publication-title: Cell doi: 10.1016/j.cell.2008.01.020 – volume: 278 start-page: 12006 year: 2003 ident: 1799_CR7 publication-title: J Biol Chem doi: 10.1074/jbc.M210768200 – volume: 316 start-page: 285 year: 2007 ident: 1799_CR22 publication-title: Science doi: 10.1126/science.1137221 – volume: 109 start-page: S81 issue: Suppl year: 2002 ident: 1799_CR1 publication-title: Cell doi: 10.1016/S0092-8674(02)00703-1 – volume: 72 start-page: 1161 year: 2006 ident: 1799_CR11 publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2006.08.007 – volume: 278 start-page: 23278 year: 2003 ident: 1799_CR6 publication-title: J Biol Chem doi: 10.1074/jbc.M300106200 – volume: 25 start-page: 6706 year: 2006 ident: 1799_CR4 publication-title: Oncogene doi: 10.1038/sj.onc.1209933 – volume: 168 start-page: 5079 year: 2002 ident: 1799_CR28 publication-title: J Immunol doi: 10.4049/jimmunol.168.10.5079 – volume: 4 start-page: 597 year: 1999 ident: 1799_CR35 publication-title: Mol Cell doi: 10.1016/S1097-2765(00)80210-5 – volume: 18 start-page: 2195 year: 2004 ident: 1799_CR2 publication-title: Genes Dev doi: 10.1101/gad.1228704 – volume: 23 start-page: 539 year: 2005 ident: 1799_CR30 publication-title: Immunity doi: 10.1016/j.immuni.2005.10.002 – volume: 11 start-page: 1563 year: 2003 ident: 1799_CR25 publication-title: Mol Cell doi: 10.1016/S1097-2765(03)00227-2 – volume: 213 start-page: 353 year: 2008 ident: 1799_CR41 publication-title: Immunobiology doi: 10.1016/j.imbio.2007.10.011 – volume: 20 start-page: 7722 year: 2001 ident: 1799_CR26 publication-title: Oncogene doi: 10.1038/sj.onc.1204868 – volume: 80 start-page: 331 year: 1995 ident: 1799_CR19 publication-title: Cell doi: 10.1016/0092-8674(95)90416-6 – volume: 282 start-page: 19167 year: 2007 ident: 1799_CR33 publication-title: J Biol Chem doi: 10.1074/jbc.M701642200 – volume: 57 start-page: 289 year: 1995 ident: 1799_CR39 publication-title: J R Stat Soc Ser B doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 22 start-page: 121 year: 2003 ident: 1799_CR9 publication-title: EMBO J doi: 10.1093/emboj/cdg004 – volume: 66 start-page: 9617 year: 2006 ident: 1799_CR34 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-0217 – volume: 17 start-page: 6419 year: 1989 ident: 1799_CR38 publication-title: Nucleic Acids Res doi: 10.1093/nar/17.15.6419 – volume: 195 start-page: 91 year: 2003 ident: 1799_CR8 publication-title: Immunol Rev doi: 10.1034/j.1600-065X.2003.00064.x – volume: 17 start-page: 525 year: 2002 ident: 1799_CR5 publication-title: Immunity doi: 10.1016/S1074-7613(02)00423-5 – volume: 278 start-page: 166 year: 2002 ident: 1799_CR23 publication-title: Exp Cell Res doi: 10.1006/excr.2002.5573 – volume: 23 start-page: 4202 year: 2004 ident: 1799_CR31 publication-title: EMBO J doi: 10.1038/sj.emboj.7600391 – volume: 25 start-page: 280 year: 2004 ident: 1799_CR10 publication-title: Trends Immunol doi: 10.1016/j.it.2004.03.008 – volume: 128 start-page: 369 year: 2007 ident: 1799_CR12 publication-title: Cell doi: 10.1016/j.cell.2006.12.033 – volume: 28 start-page: 3139 year: 2008 ident: 1799_CR13 publication-title: Mol Cell Biol doi: 10.1128/MCB.01469-07 – volume: 3 start-page: 292 year: 2003 ident: 1799_CR15 publication-title: Nat Rev Immunol doi: 10.1038/nri1054 – volume: 67 start-page: 577 year: 2000 ident: 1799_CR32 publication-title: J Leukoc Biol doi: 10.1002/jlb.67.4.577 – volume: 19 start-page: 187 year: 2008 ident: 1799_CR14 publication-title: Cytokine Growth Factor Rev doi: 10.1016/j.cytogfr.2008.04.005 – volume: 25 start-page: 2130 year: 2005 ident: 1799_CR24 publication-title: Mol Cell Biol doi: 10.1128/MCB.25.6.2130-2137.2005 – volume: 174 start-page: 5526 year: 2005 ident: 1799_CR27 publication-title: J Immunol doi: 10.4049/jimmunol.174.9.5526 – volume: 9 start-page: 415 year: 2008 ident: 1799_CR29 publication-title: Nat Immunol doi: 10.1038/ni1573 – volume: 376 start-page: 167 year: 1995 ident: 1799_CR18 publication-title: Nature doi: 10.1038/376167a0 – volume: 202 start-page: 49 year: 2004 ident: 1799_CR16 publication-title: Immunol Rev doi: 10.1111/j.0105-2896.2004.00206.x – volume: 175 start-page: 1295 year: 2005 ident: 1799_CR21 publication-title: J Immunol doi: 10.4049/jimmunol.175.2.1295 – volume: 132 start-page: 365 year: 2000 ident: 1799_CR40 publication-title: Methods Mol Biol – volume: 23 start-page: 787 year: 2005 ident: 1799_CR17 publication-title: Annu Rev Immunol doi: 10.1146/annurev.immunol.23.021704.115719 – volume: 9 start-page: 3289 year: 1994 ident: 1799_CR37 publication-title: Oncogene |
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| Snippet | Background
Lymphotoxin signaling via the lymphotoxin-β receptor (LTβR) has been implicated in biological processes ranging from development of secondary... Abstract Background Lymphotoxin signaling via the lymphotoxin-β receptor (LTβR) has been implicated in biological processes ranging from development of... |
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| StartPage | 606 |
| SubjectTerms | Animal Genetics and Genomics Biomedical and Life Sciences Cellular signal transduction DNA binding proteins Fibroblasts Genetic aspects Health aspects Life Sciences Microarrays Microbial Genetics and Genomics Physiological aspects Plant Genetics and Genomics Proteomics Research Article |
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| Title | Differential RelA- and RelB-dependent gene transcription in LTβR-stimulated mouse embryonic fibroblasts |
| URI | https://link.springer.com/article/10.1186/1471-2164-9-606 https://pubmed.ncbi.nlm.nih.gov/PMC2637282 https://doaj.org/article/7d4447a4f9ef4068b77b9586a9425a1c |
| Volume | 9 |
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