Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling

It is widely accepted that the essential role of TRAF6 in vivo is to generate the Lys63-linked ubiquitin (K63-Ub) chains needed to activate the "master" protein kinase TAK1. Here, we report that TRAF6 E3 ligase activity contributes to but is not essential for the IL-1-dependent formation o...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 17; p. E3481
Main Authors:	Strickson, Sam, Emmerich, Christoph H, Goh, Eddy T H, Zhang, Jiazhen, Kelsall, Ian R, Macartney, Thomas, Hastie, C James, Knebel, Axel, Peggie, Mark, Marchesi, Francesco, Arthur, J Simon C, Cohen, Philip
Format:	Journal Article
Language:	English
Published:	United States 25.04.2017
Subjects:	Amino Acid Substitution Animals Gene Knockdown Techniques HEK293 Cells Humans Intracellular Signaling Peptides and Proteins MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism Mice Mice, Knockout Mutation, Missense Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Polyubiquitin - genetics Polyubiquitin - metabolism RANK Ligand - genetics RANK Ligand - metabolism Signal Transduction TNF Receptor-Associated Factor 6 - genetics TNF Receptor-Associated Factor 6 - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitin TAK1 IL-1 Pellino TRAF6
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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