Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression

Preclinical and clinical studies suggest that inflammation and vascular dysfunction contribute to the pathogenesis of major depressive disorder (MDD). Chronic social stress alters blood-brain barrier (BBB) integrity through loss of tight junction protein claudin-5 (cldn5) in male mice, promoting pas...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 6; p. 3326
Main Authors:	Dudek, Katarzyna A, Dion-Albert, Laurence, Lebel, Manon, LeClair, Katherine, Labrecque, Simon, Tuck, Ellen, Ferrer Perez, Carmen, Golden, Sam A, Tamminga, Carol, Turecki, Gustavo, Mechawar, Naguib, Russo, Scott J, Menard, Caroline
Format:	Journal Article
Language:	English
Published:	United States 11.02.2020
Subjects:	Animals Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Blood-Brain Barrier - metabolism Claudin-5 - metabolism Depression - drug therapy Depression - metabolism Depressive Disorder, Major - metabolism Disease Models, Animal Epigenesis, Genetic - drug effects Epigenesis, Genetic - physiology Histone Deacetylase 1 - metabolism Humans Inflammation - metabolism Male Mice Mice, Inbred C57BL Nucleus Accumbens - metabolism Signal Transduction - drug effects Signal Transduction - physiology Stress, Psychological - metabolism epigenetic inflammation vascular mood disorders antidepressant
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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