Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression

Preclinical and clinical studies suggest that inflammation and vascular dysfunction contribute to the pathogenesis of major depressive disorder (MDD). Chronic social stress alters blood-brain barrier (BBB) integrity through loss of tight junction protein claudin-5 (cldn5) in male mice, promoting pas...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 117; H. 6; S. 3326
Hauptverfasser:	Dudek, Katarzyna A, Dion-Albert, Laurence, Lebel, Manon, LeClair, Katherine, Labrecque, Simon, Tuck, Ellen, Ferrer Perez, Carmen, Golden, Sam A, Tamminga, Carol, Turecki, Gustavo, Mechawar, Naguib, Russo, Scott J, Menard, Caroline
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 11.02.2020
Schlagworte:	Animals Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Blood-Brain Barrier - metabolism Claudin-5 - metabolism Depression - drug therapy Depression - metabolism Depressive Disorder, Major - metabolism Disease Models, Animal Epigenesis, Genetic - drug effects Epigenesis, Genetic - physiology Histone Deacetylase 1 - metabolism Humans Inflammation - metabolism Male Mice Mice, Inbred C57BL Nucleus Accumbens - metabolism Signal Transduction - drug effects Signal Transduction - physiology Stress, Psychological - metabolism epigenetic inflammation vascular mood disorders antidepressant
ISSN:	1091-6490, 1091-6490
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