Rapid hippocampal plasticity supports motor sequence learning

Recent evidence suggests that gains in performance observed while humans learn a novel motor sequence occur during the quiet rest periods interleaved with practice (micro-offline gains, MOGs). This phenomenon is reminiscent of memory replay observed in the hippocampus during spatial learning in rode...

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Vydané v:Proceedings of the National Academy of Sciences - PNAS Ročník 117; číslo 38; s. 23898
Hlavní autori: Jacobacci, Florencia, Armony, Jorge L, Yeffal, Abraham, Lerner, Gonzalo, Amaro, Jr, Edson, Jovicich, Jorge, Doyon, Julien, Della-Maggiore, Valeria
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 22.09.2020
Predmet:
Adolescent
Adult
Female
Hippocampus - physiology
Humans
Learning - physiology
Magnetic Resonance Imaging
Male
Memory
Motor Skills - physiology
Young Adult
functional MRI
structural plasticity
reactivation
hippocampus
motor sequence learning
ISSN:1091-6490, 1091-6490
On-line prístup:Zistit podrobnosti o prístupe
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Shrnutí:Recent evidence suggests that gains in performance observed while humans learn a novel motor sequence occur during the quiet rest periods interleaved with practice (micro-offline gains, MOGs). This phenomenon is reminiscent of memory replay observed in the hippocampus during spatial learning in rodents. Whether the hippocampus is also involved in the production of MOGs remains currently unknown. Using a multimodal approach in humans, here we show that activity in the hippocampus and the precuneus increases during the quiet rest periods and predicts the level of MOGs before asymptotic performance is achieved. These functional changes were followed by rapid alterations in brain microstructure in the order of minutes, suggesting that the same network that reactivates during the quiet periods of training undergoes structural plasticity. Our work points to the involvement of the hippocampal system in the reactivation of procedural memories.
Bibliografia:ObjectType-Article-1
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content type line 23
ISSN:1091-6490
1091-6490
DOI:10.1073/pnas.2009576117