DNA damage tolerance in hematopoietic stem and progenitor cells in mice

DNA damage tolerance (DDT) enables bypassing of DNA lesions during replication, thereby preventing fork stalling, replication stress, and secondary DNA damage related to fork stalling. Three modes of DDT have been documented: translesion synthesis (TLS), template switching (TS), and repriming. TLS a...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 33; p. E6875
Main Authors:	Pilzecker, Bas, Buoninfante, Olimpia Alessandra, van den Berk, Paul, Lancini, Cesare, Song, Ji-Ying, Citterio, Elisabetta, Jacobs, Heinz
Format:	Journal Article
Language:	English
Published:	United States 15.08.2017
Subjects:	hematopoietic stem and progenitor cells DNA damage tolerance template switching proliferating cell nuclear antigen K164 ubiquitination translesion synthesis
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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