Soya isoflavone consumption in relation to carotid intima–media thickness in Chinese equol excretors aged 40–65 years

Previous studies have suggested that the daidzein metabolite equol rather than daidzein itself contributes to the beneficial effect of soya foods in the prevention of CVD. The aim of the present study is to examine the proportion of equol excretion in Chinese adults and compare plasma lipids and car...

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Vydáno v:	British journal of nutrition Ročník 108; číslo 9; s. 1698 - 1704
Hlavní autoři:	Cai, Yun, Guo, Kaiping, Chen, Chaogang, Wang, Ping, Zhang, Bo, Zhou, Quan, Mei, Fang, Su, Yixiang
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cambridge, UK Cambridge University Press 14.11.2012
Témata:	Adult adults Aged Biological and medical sciences blood lipids blood serum Cardiovascular disease Cardiovascular Diseases - ethnology Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cardiovascular Diseases - prevention & control carotid arteries Carotid Arteries - diagnostic imaging Carotid Arteries - pathology Carotid Intima-Media Thickness China - epidemiology daidzein Diet Diet - ethnology Dietary Surveys and Nutritional Epidemiology Equol - administration & dosage Equol - metabolism Equol - urine excretion fasting Feeding. Feeding behavior Female food intake foods Fundamental and applied biological sciences. Psychology Glycine max - chemistry high density lipoprotein cholesterol Humans Isoflavones - administration & dosage Isoflavones - metabolism Isoflavones - therapeutic use Isoflavones - urine Lipids Lipids - blood Male men Metabolites Middle Aged Nutrition research Phytoestrogens - administration & dosage Phytoestrogens - metabolism Phytoestrogens - therapeutic use Phytoestrogens - urine Risk Factors Seeds - chemistry Soybeans Surveys and Questionnaires ultrasonics urine Vertebrates: anatomy and physiology, studies on body, several organs or systems women Blood lipids Carotid artery intima–media thickness Equol Isoflavones Isoflavone Media Lipids Artery Blood Thickness Vertebrata Mammalia Food intake Blood vessel Carotid Chinese Carotid artery intima—media thickness Circulatory system
ISSN:	0007-1145, 1475-2662, 1475-2662
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Shrnutí:	Previous studies have suggested that the daidzein metabolite equol rather than daidzein itself contributes to the beneficial effect of soya foods in the prevention of CVD. The aim of the present study is to examine the proportion of equol excretion in Chinese adults and compare plasma lipids and carotid artery intima–media thickness (IMT) between equol excretors and non-excretors, and to evaluate the effect of soya isoflavone intakes on serum lipids and IMT in either equol excretors or non-excretors. Subjects (n 572; women n 362, men n 210) were recruited for the present study. An overnight urine sample was provided by each subject on their usual diet to quantify urinary concentrations of daidzein and equol. Far-wall IMT was determined by B-mode ultrasound in the right carotid at two sites, carotid bulb (CB-IMT) and common carotid artery (CCA-IMT), and fasting serum lipids were measured. Habitual dietary intakes were estimated with a FFQ, and soya isoflavone intake derived from the FFQ was assessed. Of the 572 subjects, the proportion of equol excretors on their usual diet was 25·0 % (n 143). Compared with non-excretors, equol excretors showed significantly lower serum TAG ( − 38·2 (95 % CI − 70·4, − 5·9) %, P = 0·012) and CCA-IMT ( − 4·9 (95 % CI − 9·7, − 0·3) %, P = 0·033). Equol excretors with higher daily isoflavone intakes ( − 5·4 mg/d) had significantly lower IMT ( − 16·2 %, P = 0·035) and tended to have higher HDL-cholesterol (P = 0·055) than did those with lower daily isoflavone intakes (1·5 mg/d), while no association was observed between soya isoflavone intakes and serum lipids or IMT in non-excretors. In conclusion, the benefits of soya isoflavones in preventing CVD may be apparent among equol excretors only.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0007-1145 1475-2662 1475-2662
DOI:	10.1017/S0007114511007331