Carboxypeptidase U (TAFIa): a metallocarboxypeptidase with a distinct role in haemostasis and a possible risk factor for thrombotic disease

Since the discovery of Carboxypeptidase U (CPU) in 1988, considerable information has been gathered about its biochemistry and function in physiological and pathophysiological circumstances. A variety of tools such as assays to measure proCPU and CPU, antibodies raised against (pro)CPU, selective CP...

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Vydáno v:Thrombosis and haemostasis Ročník 94; číslo 3; s. 471
Hlavní autoři: Leurs, Judith, Hendriks, Dirk
Médium: Journal Article
Jazyk:angličtina
Vydáno: Germany 01.09.2005
Témata:
3-Mercaptopropionic Acid - analogs & derivatives
3-Mercaptopropionic Acid - pharmacology
3-Mercaptopropionic Acid - therapeutic use
Animals
Blood Platelets - metabolism
Carboxypeptidase B2 - antagonists & inhibitors
Carboxypeptidase B2 - blood
Carboxypeptidase B2 - physiology
Enzyme Stability
Fibrinolysin - metabolism
Hemostasis - physiology
Humans
Liver - metabolism
Mice
Mice, Knockout
Polymorphism, Genetic
Protein Denaturation
Risk Factors
Succinates - pharmacology
Succinates - therapeutic use
Thrombin - metabolism
Thrombosis - drug therapy
Thrombosis - etiology
Thrombosis - physiopathology
ISSN:0340-6245
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Popis
Shrnutí:Since the discovery of Carboxypeptidase U (CPU) in 1988, considerable information has been gathered about its biochemistry and function in physiological and pathophysiological circumstances. A variety of tools such as assays to measure proCPU and CPU, antibodies raised against (pro)CPU, selective CPU inhibitors and knock-out mice have been developed and are currently being used to explore the role of this metallocarboxypeptidase in different in vivo and in vitro settings. The knowledge that proCPU can be activated by thrombin and plasmin, enzymes with a key function in coagulation and fibrinolysis, and the ability of CPU to remove C-terminal lysine residues has led to the hypothesis that the proCPU/CPU pathway plays a role in the balance between coagulation and fibrinolysis. The maintenance of the equilibrium between coagulation and fibrinolysis is crucial for normal haemostasis and disturbance of this delicate balance can lead either to bleeding tendency or thrombosis. This review provides an update on several aspects of CPU known at the moment, including an extensive overview on the clinical studies performed up till now.
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ISSN:0340-6245
DOI:10.1160/TH04-07-0454