Small molecule ISRIB suppresses the integrated stress response within a defined window of activation

Activation of the integrated stress response (ISR) by a variety of stresses triggers phosphorylation of the α-subunit of translation initiation factor eIF2. P-eIF2α inhibits eIF2B, the guanine nucleotide exchange factor that recycles inactive eIF2•GDP to active eIF2•GTP. eIF2 phosphorylation thereby...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 6; p. 2097
Main Authors:	Rabouw, Huib H, Langereis, Martijn A, Anand, Aditya A, Visser, Linda J, de Groot, Raoul J, Walter, Peter, van Kuppeveld, Frank J M
Format:	Journal Article
Language:	English
Published:	United States 05.02.2019
Subjects:	Acetamides - chemistry Acetamides - pharmacology Animals Arsenites - pharmacology Cell Line Cyclohexylamines - chemistry Cyclohexylamines - pharmacology Eukaryotic Initiation Factor-2 - antagonists & inhibitors Eukaryotic Initiation Factor-2 - metabolism Humans Phosphorylation Picornaviridae Picornaviridae Infections - metabolism Picornaviridae Infections - virology Poly I-C - pharmacology Stress, Physiological - drug effects P-eIF2 ISRIB eIF2B integrated stress response
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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