TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria

Systemic infections with Gram-negative bacteria are characterized by high mortality rates due to the "sepsis syndrome," a widespread and uncontrolled inflammatory response. Though it is well recognized that the immune response during Gram-negative bacterial infection is initiated after the...

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Bibliographic Details
Published in:	Cell Vol. 150; no. 3; p. 606
Main Authors:	Rathinam, Vijay A K, Vanaja, Sivapriya Kailasan, Waggoner, Lisa, Sokolovska, Anna, Becker, Christine, Stuart, Lynda M, Leong, John M, Fitzgerald, Katherine A
Format:	Journal Article
Language:	English
Published:	United States 03.08.2012
Subjects:	Adaptor Proteins, Vesicular Transport - metabolism Animals Carrier Proteins - metabolism Caspases - metabolism Citrobacter rodentium - immunology Citrobacter rodentium - metabolism Enterohemorrhagic Escherichia coli - immunology Enterohemorrhagic Escherichia coli - metabolism Gram-Negative Bacteria - immunology Gram-Negative Bacteria - metabolism Gram-Positive Bacteria - immunology Gram-Positive Bacteria - metabolism Inflammasomes - metabolism Interferons - metabolism Mice NLR Family, Pyrin Domain-Containing 3 Protein Signal Transduction
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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