Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma

Esophageal adenocarcinoma (EAC) has a dismal prognosis, and survival benefits of recent multimodality treatments remain small. Cancer-associated fibroblasts (CAFs) are known to contribute to poor outcome by conferring therapy resistance to various cancer types, but this has not been explored in EAC....

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 116; H. 6; S. 2237
Hauptverfasser:	Ebbing, Eva A, van der Zalm, Amber P, Steins, Anne, Creemers, Aafke, Hermsen, Simone, Rentenaar, Rosa, Klein, Michelle, Waasdorp, Cynthia, Hooijer, Gerrit K J, Meijer, Sybren L, Krishnadath, Kausilia K, Punt, Cornelis J A, van Berge Henegouwen, Mark I, Gisbertz, Suzanne S, van Delden, Otto M, Hulshof, Maarten C C M, Medema, Jan Paul, van Laarhoven, Hanneke W M, Bijlsma, Maarten F
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.02.2019
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma - therapy Animals Antineoplastic Agents - pharmacology Cancer-Associated Fibroblasts - metabolism Cell Line, Tumor Cell Movement - drug effects Cell Movement - radiation effects Disease Models, Animal Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Drug Resistance, Neoplasm Epithelial-Mesenchymal Transition - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Humans Interleukin-6 - metabolism Mice Radiation Tolerance Stromal Cells - metabolism Tissue Culture Techniques Xenograft Model Antitumor Assays tumor stroma esophageal adenocarcinoma IL-6 epithelial-to-mesenchymal transition therapy resistance
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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