Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology

Although the hippocampus is one of the most studied structures in the human brain, limited quantitative data exist on its 3D organization, anatomical variability, and effects of disease on its subregions. Histological studies provide restricted reference information due to their 2D nature. In this p...

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Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 115; číslo 16; s. 4252
Hlavní autoři:	Adler, Daniel H, Wisse, Laura E M, Ittyerah, Ranjit, Pluta, John B, Ding, Song-Lin, Xie, Long, Wang, Jiancong, Kadivar, Salmon, Robinson, John L, Schuck, Theresa, Trojanowski, John Q, Grossman, Murray, Detre, John A, Elliott, Mark A, Toledo, Jon B, Liu, Weixia, Pickup, Stephen, Miller, Michael I, Das, Sandhitsu R, Wolk, David A, Yushkevich, Paul A
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 17.04.2018
Témata:	Aged Aging - pathology Alzheimer Disease - pathology Atlases as Topic Atrophy Dentate Gyrus - pathology Hippocampus - pathology Humans Imaging, Three-Dimensional Magnetic Resonance Imaging Neuroimaging Organ Size computational anatomy hippocampal subfields ex vivo MRI Alzheimer’s disease histology
ISSN:	1091-6490, 1091-6490
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Shrnutí:	Although the hippocampus is one of the most studied structures in the human brain, limited quantitative data exist on its 3D organization, anatomical variability, and effects of disease on its subregions. Histological studies provide restricted reference information due to their 2D nature. In this paper, high-resolution (∼200 × 200 × 200 μm ) ex vivo MRI scans of 31 human hippocampal specimens are combined using a groupwise diffeomorphic registration approach into a 3D probabilistic atlas that captures average anatomy and anatomic variability of hippocampal subfields. Serial histological imaging in 9 of the 31 specimens was used to label hippocampal subfields in the atlas based on cytoarchitecture. Specimens were obtained from autopsies in patients with a clinical diagnosis of Alzheimer's disease (AD; 9 subjects, 13 hemispheres), of other dementia (nine subjects, nine hemispheres), and in subjects without dementia (seven subjects, nine hemispheres), and morphometric analysis was performed in atlas space to measure effects of age and AD on hippocampal subfields. Disproportional involvement of the cornu ammonis (CA) 1 subfield and stratum radiatum lacunosum moleculare was found in AD, with lesser involvement of the dentate gyrus and CA2/3 subfields. An association with age was found for the dentate gyrus and, to a lesser extent, for CA1. Three-dimensional patterns of variability and disease and aging effects discovered via the ex vivo hippocampus atlas provide information highly relevant to the active field of in vivo hippocampal subfield imaging.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1091-6490 1091-6490
DOI:	10.1073/pnas.1801093115