Chromatin remodeling at DNA double-strand breaks

DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to ionizing radiation. The repair of DSBs involves both posttranslational modification of nucleosomes and concentration of DNA-repair proteins at the site of damage. Consequently, nucleosome packing and chromatin arc...

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Vydáno v:Cell Ročník 152; číslo 6; s. 1344
Hlavní autoři: Price, Brendan D, D'Andrea, Alan D
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 14.03.2013
Témata:
Animals
Chromatin Assembly and Disassembly
DNA Breaks, Double-Stranded
DNA Repair
Genomic Instability
Histones - metabolism
Humans
Neoplasms - genetics
ISSN:1097-4172, 1097-4172
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Popis
Shrnutí:DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to ionizing radiation. The repair of DSBs involves both posttranslational modification of nucleosomes and concentration of DNA-repair proteins at the site of damage. Consequently, nucleosome packing and chromatin architecture surrounding the DSB may limit the ability of the DNA-damage response to access and repair the break. Here, we review early chromatin-based events that promote the formation of open, relaxed chromatin structures at DSBs and that allow the DNA-repair machinery to access the spatially confined region surrounding the DSB, thereby facilitating mammalian DSB repair.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2013.02.011