Chromatin remodeling at DNA double-strand breaks

DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to ionizing radiation. The repair of DSBs involves both posttranslational modification of nucleosomes and concentration of DNA-repair proteins at the site of damage. Consequently, nucleosome packing and chromatin arc...

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Bibliographic Details
Published in:Cell Vol. 152; no. 6; p. 1344
Main Authors: Price, Brendan D, D'Andrea, Alan D
Format: Journal Article
Language:English
Published: United States 14.03.2013
Subjects:
Animals
Chromatin Assembly and Disassembly
DNA Breaks, Double-Stranded
DNA Repair
Genomic Instability
Histones - metabolism
Humans
Neoplasms - genetics
ISSN:1097-4172, 1097-4172
Online Access:Get more information
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Summary:DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to ionizing radiation. The repair of DSBs involves both posttranslational modification of nucleosomes and concentration of DNA-repair proteins at the site of damage. Consequently, nucleosome packing and chromatin architecture surrounding the DSB may limit the ability of the DNA-damage response to access and repair the break. Here, we review early chromatin-based events that promote the formation of open, relaxed chromatin structures at DSBs and that allow the DNA-repair machinery to access the spatially confined region surrounding the DSB, thereby facilitating mammalian DSB repair.
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ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2013.02.011