Muscarinic receptor regulates extracellular signal regulated kinase by two modes of arrestin binding

Binding of agonists to G-protein-coupled receptors (GPCRs) activates heterotrimeric G proteins and downstream signaling. Agonist-bound GPCRs are then phosphorylated by protein kinases and bound by arrestin to trigger desensitization and endocytosis. Arrestin plays another important signaling functio...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 114; číslo 28; s. E5579
Hlavní autori:	Jung, Seung-Ryoung, Kushmerick, Christopher, Seo, Jong Bae, Koh, Duk-Su, Hille, Bertil
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 11.07.2017
Predmet:	GPCR arrestin muscarinic receptor ERK receptor kinase
ISSN:	1091-6490, 1091-6490
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