Muscarinic receptor regulates extracellular signal regulated kinase by two modes of arrestin binding

Binding of agonists to G-protein-coupled receptors (GPCRs) activates heterotrimeric G proteins and downstream signaling. Agonist-bound GPCRs are then phosphorylated by protein kinases and bound by arrestin to trigger desensitization and endocytosis. Arrestin plays another important signaling functio...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 28; p. E5579
Main Authors:	Jung, Seung-Ryoung, Kushmerick, Christopher, Seo, Jong Bae, Koh, Duk-Su, Hille, Bertil
Format:	Journal Article
Language:	English
Published:	United States 11.07.2017
Subjects:	GPCR arrestin muscarinic receptor ERK receptor kinase
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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