Non-coding RNA networks in cancer

Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from 'junk' transcriptional products to functional regulatory molecules that mediate cellular processes including chromatin remodelling, transcription, po...

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Vydáno v:Nature reviews. Cancer Ročník 18; číslo 1; s. 5
Hlavní autoři: Anastasiadou, Eleni, Jacob, Leni S, Slack, Frank J
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Nature Publishing Group 01.01.2018
Témata:
Animals
Cancer
Chromatin remodeling
Humans
Neoplasms - genetics
Non-coding RNA
Post-transcription
RNA Processing, Post-Transcriptional - genetics
RNA, Untranslated - genetics
Signal transduction
Signal Transduction - genetics
Therapeutic applications
Transcription, Genetic - genetics
Transduction
Tumors
ISSN:1474-175X, 1474-1768, 1474-1768
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Shrnutí:Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from 'junk' transcriptional products to functional regulatory molecules that mediate cellular processes including chromatin remodelling, transcription, post-transcriptional modifications and signal transduction. The networks in which ncRNAs engage can influence numerous molecular targets to drive specific cell biological responses and fates. Consequently, ncRNAs act as key regulators of physiological programmes in developmental and disease contexts. Particularly relevant in cancer, ncRNAs have been identified as oncogenic drivers and tumour suppressors in every major cancer type. Thus, a deeper understanding of the complex networks of interactions that ncRNAs coordinate would provide a unique opportunity to design better therapeutic interventions.
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ISSN:1474-175X
1474-1768
1474-1768
DOI:10.1038/nrc.2017.99