CircRNA: a novel type of biomarker for cancer

Circular RNAs (circRNAs) are a class of long, non-coding RNAs molecules that shape a covalently closed continuous loop which have no 5′–3′ polarity and contain no polyA tail. CircRNAs also possess relatively jarless framework and are highly tissue-specific expressed in the eukaryotic transcriptome....

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Published in:Breast cancer (Tokyo, Japan) Vol. 25; no. 1; pp. 1 - 7
Main Authors: Zhang, He-da, Jiang, Lin-hong, Sun, Da-wei, Hou, Jun-chen, Ji, Zhen-ling
Format: Journal Article
Language:English
Published: Tokyo Springer Japan 01.01.2018
Springer
Subjects:
Animals
Biomarkers - analysis
Blood circulation disorders
Breast Neoplasms - diagnosis
Breast Neoplasms - genetics
Cancer
Cancer Research
Cells
Colorectal cancer
Female
Genes
Genetic aspects
Genetic transcription
Health aspects
Humans
Medicine
Medicine & Public Health
MicroRNA
Oncology
Osteoarthritis
Review Article
RNA - genetics
RNA, Long Noncoding - genetics
Surgery
Surgical Oncology
Circular RNA
Biomarker
MicroRNA
Cancer
ISSN:1340-6868, 1880-4233, 1880-4233
Online Access:Get full text
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Summary:Circular RNAs (circRNAs) are a class of long, non-coding RNAs molecules that shape a covalently closed continuous loop which have no 5′–3′ polarity and contain no polyA tail. CircRNAs also possess relatively jarless framework and are highly tissue-specific expressed in the eukaryotic transcriptome. Emerging evidences have discovered that thousands of endogenous circRNAs are present in mammalian cells and they mediate gene expression at the transcriptional or post-transcriptional level by binding to microRNAs or other molecules and then inhibit their function. Similarly, increasing evidence indicates that circRNAs may play a role in the development of several types of diseases, including atherosclerotic vascular disease risk, neurological disorders, prion diseases, osteoarthritis and diabetes. Furthermore, circRNAs exhibit aberrant expression in multiform types of cancer, including colorectal cancer, hepatocellular carcinoma and pancreatic ductal adenocarcinoma. And based on the function of circRNAs in cancer, we believe that circRNAs may serve as diagnostic or tumor promising biomarkers. Moreover, it will provide a new therapeutic target for the treatment of cancer.
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ISSN:1340-6868
1880-4233
1880-4233
DOI:10.1007/s12282-017-0793-9