The Mediterranean Diet is Not Related to Cognitive Change in a Large Prospective Investigation: The PATH Through Life Study

To determine whether the Mediterranean diet and other dietary variables are predictors of transition from healthy cognitive aging to mild cognitive impairment and cognitive decline. Longitudinal. We assessed 1528 individuals, aged 60–64 years, who were participating in a prospective epidemiological...

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Bibliographic Details
Published in:The American journal of geriatric psychiatry Vol. 20; no. 7; pp. 635 - 639
Main Authors: Cherbuin, Nicolas, Anstey, Kaarin J.
Format: Journal Article
Language:English
Published: England Elsevier Inc 01.07.2012
Elsevier Limited
Subjects:
Aged
Aging
Aging - psychology
Caloric intake
Cognition
Cognitive change
Cognitive Dysfunction - prevention & control
Cognitive impairment
Comorbidity
Criteria
Dementia
Dementia - prevention & control
Diet
Diet, High-Fat - adverse effects
Diet, Mediterranean - psychology
Energy Intake
Epidemiology
Fats
Female
Humans
Internal Medicine
Male
Measures
Mediterranean diet
Mental health
Middle Aged
mild cognitive impairment
monounsaturated fat
Neuropsychological Tests - statistics & numerical data
Prospective Studies
Ratings & rankings
Risk Factors
monounsaturated fat
caloric intake
Cognition
mild cognitive impairment
Mediterranean diet
ISSN:1064-7481, 1545-7214, 1545-7214
Online Access:Get full text
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Summary:To determine whether the Mediterranean diet and other dietary variables are predictors of transition from healthy cognitive aging to mild cognitive impairment and cognitive decline. Longitudinal. We assessed 1528 individuals, aged 60–64 years, who were participating in a prospective epidemiological study of mental health and aging. We tested participants at two time points, 4 years apart, for mild cognitive impairment using either the International Consensus Criteria, impairment on the Clinical Dementia Rating scale (Clinical Dementia Rating: 0.5), or any of a suite of criteria sets (any mild cognitive disorder). We used logistic regression to assess the dietary predictors of conversion to clinical diagnoses and multiple regression to identify the predictors of cognitive decline (change in global cognition) in healthy participants. Of the 1528 participants with no cognitive impairment in the first wave of assessment and complete data, 10 participants were diagnosed with mild cognitive impairment, 19 with Clinical Dementia Rating 0.5, and 37 participants presented with any mild cognitive disorder at follow-up. Adherence to Mediterranean diet was not found to be protective against cognitive decline but excessive caloric intake, and high intake of monounsaturated fats was predictive of mild cognitive impairment. In this large longitudinal investigation of generally healthy individuals Mediterranean diet was not found to be protective of cognitive decline.
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ISSN:1064-7481
1545-7214
1545-7214
DOI:10.1097/JGP.0b013e31823032a9