The Mediterranean Diet is Not Related to Cognitive Change in a Large Prospective Investigation: The PATH Through Life Study

To determine whether the Mediterranean diet and other dietary variables are predictors of transition from healthy cognitive aging to mild cognitive impairment and cognitive decline. Longitudinal. We assessed 1528 individuals, aged 60–64 years, who were participating in a prospective epidemiological...

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Published in:	The American journal of geriatric psychiatry Vol. 20; no. 7; pp. 635 - 639
Main Authors:	Cherbuin, Nicolas, Anstey, Kaarin J.
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 01.07.2012 Elsevier Limited
Subjects:	Aged Aging Aging - psychology Caloric intake Cognition Cognitive change Cognitive Dysfunction - prevention & control Cognitive impairment Comorbidity Criteria Dementia Dementia - prevention & control Diet Diet, High-Fat - adverse effects Diet, Mediterranean - psychology Energy Intake Epidemiology Fats Female Humans Internal Medicine Male Measures Mediterranean diet Mental health Middle Aged mild cognitive impairment monounsaturated fat Neuropsychological Tests - statistics & numerical data Prospective Studies Ratings & rankings Risk Factors monounsaturated fat caloric intake Cognition mild cognitive impairment Mediterranean diet
ISSN:	1064-7481, 1545-7214, 1545-7214
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Abstract	To determine whether the Mediterranean diet and other dietary variables are predictors of transition from healthy cognitive aging to mild cognitive impairment and cognitive decline. Longitudinal. We assessed 1528 individuals, aged 60–64 years, who were participating in a prospective epidemiological study of mental health and aging. We tested participants at two time points, 4 years apart, for mild cognitive impairment using either the International Consensus Criteria, impairment on the Clinical Dementia Rating scale (Clinical Dementia Rating: 0.5), or any of a suite of criteria sets (any mild cognitive disorder). We used logistic regression to assess the dietary predictors of conversion to clinical diagnoses and multiple regression to identify the predictors of cognitive decline (change in global cognition) in healthy participants. Of the 1528 participants with no cognitive impairment in the first wave of assessment and complete data, 10 participants were diagnosed with mild cognitive impairment, 19 with Clinical Dementia Rating 0.5, and 37 participants presented with any mild cognitive disorder at follow-up. Adherence to Mediterranean diet was not found to be protective against cognitive decline but excessive caloric intake, and high intake of monounsaturated fats was predictive of mild cognitive impairment. In this large longitudinal investigation of generally healthy individuals Mediterranean diet was not found to be protective of cognitive decline.
AbstractList	To determine whether the Mediterranean diet and other dietary variables are predictors of transition from healthy cognitive aging to mild cognitive impairment and cognitive decline.OBJECTIVETo determine whether the Mediterranean diet and other dietary variables are predictors of transition from healthy cognitive aging to mild cognitive impairment and cognitive decline.Longitudinal.DESIGNLongitudinal.We assessed 1528 individuals, aged 60-64 years, who were participating in a prospective epidemiological study of mental health and aging. We tested participants at two time points, 4 years apart, for mild cognitive impairment using either the International Consensus Criteria, impairment on the Clinical Dementia Rating scale (Clinical Dementia Rating: 0.5), or any of a suite of criteria sets (any mild cognitive disorder). We used logistic regression to assess the dietary predictors of conversion to clinical diagnoses and multiple regression to identify the predictors of cognitive decline (change in global cognition) in healthy participants.PARTICIPANTSWe assessed 1528 individuals, aged 60-64 years, who were participating in a prospective epidemiological study of mental health and aging. We tested participants at two time points, 4 years apart, for mild cognitive impairment using either the International Consensus Criteria, impairment on the Clinical Dementia Rating scale (Clinical Dementia Rating: 0.5), or any of a suite of criteria sets (any mild cognitive disorder). We used logistic regression to assess the dietary predictors of conversion to clinical diagnoses and multiple regression to identify the predictors of cognitive decline (change in global cognition) in healthy participants.Of the 1528 participants with no cognitive impairment in the first wave of assessment and complete data, 10 participants were diagnosed with mild cognitive impairment, 19 with Clinical Dementia Rating 0.5, and 37 participants presented with any mild cognitive disorder at follow-up. Adherence to Mediterranean diet was not found to be protective against cognitive decline but excessive caloric intake, and high intake of monounsaturated fats was predictive of mild cognitive impairment.RESULTSOf the 1528 participants with no cognitive impairment in the first wave of assessment and complete data, 10 participants were diagnosed with mild cognitive impairment, 19 with Clinical Dementia Rating 0.5, and 37 participants presented with any mild cognitive disorder at follow-up. Adherence to Mediterranean diet was not found to be protective against cognitive decline but excessive caloric intake, and high intake of monounsaturated fats was predictive of mild cognitive impairment.In this large longitudinal investigation of generally healthy individuals Mediterranean diet was not found to be protective of cognitive decline.CONCLUSIONSIn this large longitudinal investigation of generally healthy individuals Mediterranean diet was not found to be protective of cognitive decline. To determine whether the Mediterranean diet and other dietary variables are predictors of transition from healthy cognitive aging to mild cognitive impairment and cognitive decline. Longitudinal. We assessed 1528 individuals, aged 60-64 years, who were participating in a prospective epidemiological study of mental health and aging. We tested participants at two time points, 4 years apart, for mild cognitive impairment using either the International Consensus Criteria, impairment on the Clinical Dementia Rating scale (Clinical Dementia Rating: 0.5), or any of a suite of criteria sets (any mild cognitive disorder). We used logistic regression to assess the dietary predictors of conversion to clinical diagnoses and multiple regression to identify the predictors of cognitive decline (change in global cognition) in healthy participants. Of the 1528 participants with no cognitive impairment in the first wave of assessment and complete data, 10 participants were diagnosed with mild cognitive impairment, 19 with Clinical Dementia Rating 0.5, and 37 participants presented with any mild cognitive disorder at follow-up. Adherence to Mediterranean diet was not found to be protective against cognitive decline but excessive caloric intake, and high intake of monounsaturated fats was predictive of mild cognitive impairment. In this large longitudinal investigation of generally healthy individuals Mediterranean diet was not found to be protective of cognitive decline. To determine whether the Mediterranean diet and other dietary variables are predictors of transition from healthy cognitive aging to mild cognitive impairment and cognitive decline. Longitudinal. We assessed 1528 individuals, aged 60–64 years, who were participating in a prospective epidemiological study of mental health and aging. We tested participants at two time points, 4 years apart, for mild cognitive impairment using either the International Consensus Criteria, impairment on the Clinical Dementia Rating scale (Clinical Dementia Rating: 0.5), or any of a suite of criteria sets (any mild cognitive disorder). We used logistic regression to assess the dietary predictors of conversion to clinical diagnoses and multiple regression to identify the predictors of cognitive decline (change in global cognition) in healthy participants. Of the 1528 participants with no cognitive impairment in the first wave of assessment and complete data, 10 participants were diagnosed with mild cognitive impairment, 19 with Clinical Dementia Rating 0.5, and 37 participants presented with any mild cognitive disorder at follow-up. Adherence to Mediterranean diet was not found to be protective against cognitive decline but excessive caloric intake, and high intake of monounsaturated fats was predictive of mild cognitive impairment. In this large longitudinal investigation of generally healthy individuals Mediterranean diet was not found to be protective of cognitive decline. Objective To determine whether the Mediterranean diet and other dietary variables are predictors of transition from healthy cognitive aging to mild cognitive impairment and cognitive decline. Design Longitudinal. Participants We assessed 1528 individuals, aged 60–64 years, who were participating in a prospective epidemiological study of mental health and aging. We tested participants at two time points, 4 years apart, for mild cognitive impairment using either the International Consensus Criteria, impairment on the Clinical Dementia Rating scale (Clinical Dementia Rating: 0.5), or any of a suite of criteria sets (any mild cognitive disorder). We used logistic regression to assess the dietary predictors of conversion to clinical diagnoses and multiple regression to identify the predictors of cognitive decline (change in global cognition) in healthy participants. Results Of the 1528 participants with no cognitive impairment in the first wave of assessment and complete data, 10 participants were diagnosed with mild cognitive impairment, 19 with Clinical Dementia Rating 0.5, and 37 participants presented with any mild cognitive disorder at follow-up. Adherence to Mediterranean diet was not found to be protective against cognitive decline but excessive caloric intake, and high intake of monounsaturated fats was predictive of mild cognitive impairment. Conclusions In this large longitudinal investigation of generally healthy individuals Mediterranean diet was not found to be protective of cognitive decline.
Author	Cherbuin, Nicolas Anstey, Kaarin J.
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Copyright	2012 American Association for Geriatric Psychiatry American Association for Geriatric Psychiatry Copyright Lippincott Williams & Wilkins Jul 2012
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Snippet	To determine whether the Mediterranean diet and other dietary variables are predictors of transition from healthy cognitive aging to mild cognitive impairment... Objective To determine whether the Mediterranean diet and other dietary variables are predictors of transition from healthy cognitive aging to mild cognitive...
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SubjectTerms	Aged Aging Aging - psychology Caloric intake Cognition Cognitive change Cognitive Dysfunction - prevention & control Cognitive impairment Comorbidity Criteria Dementia Dementia - prevention & control Diet Diet, High-Fat - adverse effects Diet, Mediterranean - psychology Energy Intake Epidemiology Fats Female Humans Internal Medicine Male Measures Mediterranean diet Mental health Middle Aged mild cognitive impairment monounsaturated fat Neuropsychological Tests - statistics & numerical data Prospective Studies Ratings & rankings Risk Factors
Title	The Mediterranean Diet is Not Related to Cognitive Change in a Large Prospective Investigation: The PATH Through Life Study
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