PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs

Most BRAF (V600E) mutant melanomas are sensitive to selective BRAF inhibitors, but BRAF mutant colon cancers are intrinsically resistant to these drugs because of feedback activation of EGFR. We performed an RNA-interference-based genetic screen in BRAF mutant colon cancer cells to search for phosph...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 12; no. 12; pp. 1978 - 1985
Main Authors:	Prahallad, Anirudh, Heynen, Guus J.J.E., Germano, Giovanni, Willems, Stefan M., Evers, Bastiaan, Vecchione, Loredana, Gambino, Valentina, Lieftink, Cor, Beijersbergen, Roderick L., Di Nicolantonio, Federica, Bardelli, Alberto, Bernards, Rene
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 29.09.2015 Elsevier
Subjects:	Animals Antineoplastic Agents - pharmacology Cell Line, Tumor Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic Genetic Vectors Genomic Library High-Throughput Nucleotide Sequencing Humans Indoles - pharmacology Lentivirus - genetics MAP Kinase Signaling System Melanoma - drug therapy Melanoma - genetics Melanoma - metabolism Melanoma - pathology Mice Mice, Inbred NOD Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism ras Proteins - genetics ras Proteins - metabolism Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Sulfonamides - pharmacology Transduction, Genetic Xenograft Model Antitumor Assays
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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