Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans

Parental care influences development across mammals. In humans such influences include effects on phenotypes, such as stress reactivity, which determine individual differences in the vulnerability for affective disorders. Thus, the adult offspring of rat mothers that show an increased frequency of p...

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Bibliographic Details
Published in:	Neuropsychopharmacology (New York, N.Y.) Vol. 38; no. 1; pp. 111 - 123
Main Authors:	Zhang, Tie Yuan, Labonté, Benoit, Wen, Xiang Lan, Turecki, Gustavo, Meaney, Michael J
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.01.2013
Subjects:	Affective disorders Animals Behavior Child abuse & neglect Children Clinical outcomes Development DNA methylation Environmental regulations Epigenesis, Genetic - physiology Epigenetics Families & family life Gene expression Gene Expression Regulation Genomes Glucocorticoid receptors Grooming Hippocampus Hippocampus - physiology Histones Humans Hypothalamic-pituitary-adrenal axis Influence Intracellular signalling Maternal Behavior - physiology Maternal Behavior - psychology Mental depression Mental disorders Mental health Neuropsychopharmacology Reviews Post-translation Progeny Promoters Rats Receptors, Glucocorticoid - biosynthesis Receptors, Glucocorticoid - genetics Reviews Sex crimes Sexual abuse Social Environment Stress Canada Singapore
ISSN:	0893-133X, 1740-634X, 1740-634X
Online Access:	Get full text
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