Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries
One of the objectives of the ESC-EORP EUROASPIRE V survey is to determine how well European guidelines on the management of dyslipidaemias are implemented in coronary patients. Standardized methods were used by trained technicians to collect information on 7824 patients from 130 centers in 27 countr...
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| Veröffentlicht in: | Atherosclerosis Jg. 285; S. 135 - 146 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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Ireland
Elsevier B.V
01.06.2019
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| ISSN: | 0021-9150, 1879-1484, 1879-1484 |
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| Abstract | One of the objectives of the ESC-EORP EUROASPIRE V survey is to determine how well European guidelines on the management of dyslipidaemias are implemented in coronary patients.
Standardized methods were used by trained technicians to collect information on 7824 patients from 130 centers in 27 countries, from the medical records and at a visit at least 6 months after hospitalization for a coronary event. All lipid measurements were performed in one central laboratory. Patients were divided into three groups: on high-intensity LDL-C-lowering-drug therapy (LLT), on low or moderate-intensity LLT and on no LLT.
At the time of the visit, almost half of the patients were on a high-intensity LLT. Between hospital discharge and the visit, LLT had been reduced in intensity or interrupted in 20.8% of the patients and had been started or increased in intensity in 11.7%. In those who had interrupted LLT or had reduced the intensity, intolerance to LLT and the advice of their physician were reported as the reason why in 15.8 and 36.8% of the cases, respectively. LDL-C control was better in those on a high-intensity LLT compared to those on low or moderate intensity LLT. LDL-C control was better in men than women and in patients with self-reported diabetes.
The results of the EUROASPIRE V survey show that most coronary patients have a less than optimal management of LDL-C. More professional strategies are needed, aiming at lifestyle changes and LLT adapted to the need of the individual patient.
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•Most patients with established coronary artery disease have suboptimal lipid management.•More professional strategies are needed aiming at lifestyle changes and LLT adapted to the need of the individual patient.•The striking variability between countries and centers with several examples of well managed patients illustrates that the present conditions can be improved. |
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| AbstractList | One of the objectives of the ESC-EORP EUROASPIRE V survey is to determine how well European guidelines on the management of dyslipidaemias are implemented in coronary patients.
Standardized methods were used by trained technicians to collect information on 7824 patients from 130 centers in 27 countries, from the medical records and at a visit at least 6 months after hospitalization for a coronary event. All lipid measurements were performed in one central laboratory. Patients were divided into three groups: on high-intensity LDL-C-lowering-drug therapy (LLT), on low or moderate-intensity LLT and on no LLT.
At the time of the visit, almost half of the patients were on a high-intensity LLT. Between hospital discharge and the visit, LLT had been reduced in intensity or interrupted in 20.8% of the patients and had been started or increased in intensity in 11.7%. In those who had interrupted LLT or had reduced the intensity, intolerance to LLT and the advice of their physician were reported as the reason why in 15.8 and 36.8% of the cases, respectively. LDL-C control was better in those on a high-intensity LLT compared to those on low or moderate intensity LLT. LDL-C control was better in men than women and in patients with self-reported diabetes.
The results of the EUROASPIRE V survey show that most coronary patients have a less than optimal management of LDL-C. More professional strategies are needed, aiming at lifestyle changes and LLT adapted to the need of the individual patient.
[Display omitted]
•Most patients with established coronary artery disease have suboptimal lipid management.•More professional strategies are needed aiming at lifestyle changes and LLT adapted to the need of the individual patient.•The striking variability between countries and centers with several examples of well managed patients illustrates that the present conditions can be improved. One of the objectives of the ESC-EORP EUROASPIRE V survey is to determine how well European guidelines on the management of dyslipidaemias are implemented in coronary patients.BACKGROUND AND AIMSOne of the objectives of the ESC-EORP EUROASPIRE V survey is to determine how well European guidelines on the management of dyslipidaemias are implemented in coronary patients.Standardized methods were used by trained technicians to collect information on 7824 patients from 130 centers in 27 countries, from the medical records and at a visit at least 6 months after hospitalization for a coronary event. All lipid measurements were performed in one central laboratory. Patients were divided into three groups: on high-intensity LDL-C-lowering-drug therapy (LLT), on low or moderate-intensity LLT and on no LLT.METHODSStandardized methods were used by trained technicians to collect information on 7824 patients from 130 centers in 27 countries, from the medical records and at a visit at least 6 months after hospitalization for a coronary event. All lipid measurements were performed in one central laboratory. Patients were divided into three groups: on high-intensity LDL-C-lowering-drug therapy (LLT), on low or moderate-intensity LLT and on no LLT.At the time of the visit, almost half of the patients were on a high-intensity LLT. Between hospital discharge and the visit, LLT had been reduced in intensity or interrupted in 20.8% of the patients and had been started or increased in intensity in 11.7%. In those who had interrupted LLT or had reduced the intensity, intolerance to LLT and the advice of their physician were reported as the reason why in 15.8 and 36.8% of the cases, respectively. LDL-C control was better in those on a high-intensity LLT compared to those on low or moderate intensity LLT. LDL-C control was better in men than women and in patients with self-reported diabetes.RESULTSAt the time of the visit, almost half of the patients were on a high-intensity LLT. Between hospital discharge and the visit, LLT had been reduced in intensity or interrupted in 20.8% of the patients and had been started or increased in intensity in 11.7%. In those who had interrupted LLT or had reduced the intensity, intolerance to LLT and the advice of their physician were reported as the reason why in 15.8 and 36.8% of the cases, respectively. LDL-C control was better in those on a high-intensity LLT compared to those on low or moderate intensity LLT. LDL-C control was better in men than women and in patients with self-reported diabetes.The results of the EUROASPIRE V survey show that most coronary patients have a less than optimal management of LDL-C. More professional strategies are needed, aiming at lifestyle changes and LLT adapted to the need of the individual patient.CONCLUSIONSThe results of the EUROASPIRE V survey show that most coronary patients have a less than optimal management of LDL-C. More professional strategies are needed, aiming at lifestyle changes and LLT adapted to the need of the individual patient. One of the objectives of the ESC-EORP EUROASPIRE V survey is to determine how well European guidelines on the management of dyslipidaemias are implemented in coronary patients. Standardized methods were used by trained technicians to collect information on 7824 patients from 130 centers in 27 countries, from the medical records and at a visit at least 6 months after hospitalization for a coronary event. All lipid measurements were performed in one central laboratory. Patients were divided into three groups: on high-intensity LDL-C-lowering-drug therapy (LLT), on low or moderate-intensity LLT and on no LLT. At the time of the visit, almost half of the patients were on a high-intensity LLT. Between hospital discharge and the visit, LLT had been reduced in intensity or interrupted in 20.8% of the patients and had been started or increased in intensity in 11.7%. In those who had interrupted LLT or had reduced the intensity, intolerance to LLT and the advice of their physician were reported as the reason why in 15.8 and 36.8% of the cases, respectively. LDL-C control was better in those on a high-intensity LLT compared to those on low or moderate intensity LLT. LDL-C control was better in men than women and in patients with self-reported diabetes. The results of the EUROASPIRE V survey show that most coronary patients have a less than optimal management of LDL-C. More professional strategies are needed, aiming at lifestyle changes and LLT adapted to the need of the individual patient. |
| Author | Bajare, I. Sileikienė, V. Peachey, T. Castro, A. Rodrigo, M. Dzubur, A. Houlihan, A. Mosad, E. Baigaziev, K. Angelov, A. Amirov, B. Haberka, M. Bozkurt, E. Colman, R. Barreñada, E. Rydén, L. Rodrigues, I. Lalic, N. Kanazirev, B. Kabil, H. Kordic, K. Neronova, K. Milicic, D. Van Genechten, G. İ Yakut Bruthans, J. Gaita, L. Nesukai, V. Sousa, J. Lovic, D. Bućko, J. Aguiar, C. Idress, T. Oganov, R. Mellbin, L. Çatakoğlu, A.B. Deckers, J.W. Sokolova, O. Fernández-Olmo, M.R. Paniczko, M. Radini, D. Hövelborn, T. Bosnic, A. Cifkova, R. Stagmo, M. Vaitiekiene, A. Karpova, A. Kucika, G. Konoplianyk, L. Topic, G. Gulizia, M.M. Sanidas, E. De Backer, G. Vélez, A. Haupt, A. Vasiljevaite, K. DeSmedt, D. Crljenko, K. Guerreiro, R. Wright, J. Stensgaard-Nake, E. Christenssen, V. Kaprielian, R. Daniel, P. Lalic, K. Liszka, J. Marcos Gómez, G. Kelly, C. Gedvilaite, L. Karmann, W. Vogiatzi, G. Koutsoukis, A. Missiamenou, V. Adamska, A. Moreira, R. Mustonen, J. Martínez, G. Iglica, A. Ergene, O. Kaminska, K. Forward, H. Fras, Z. Tonkova, D. Torres-LLergo, J. Delgado, J. Wiśniewski, A. Wa |
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| ContentType | Journal Article |
| Contributor | Fras, Z Dendale, P Durak Nalbantic, A Gyberg, V Miličić, D Störk, S Dilic, M Hadzibegic, N Dekimpe, E Persu, A DeSmedt, D Aguiar, C Hasan Ali, H Sundvall, J Erglis, A Wood, D Begic, A Kapidjic, S Gaita, D Taylor, C Stagmo, M Adamska, A Wood, D A Missiamenou, V Cifkova, R Hoes, A W Chenu, P Schnell, O Glemot, M Raman, L De Bacquer, D Reiner, Ž Adamska, S Bouvier, C A Deckers, J W Pogosova, N De Sutter, J Mirrakhimov, E Vulic, D Dzubur, A Lalic, N De Pauw, M Crowley, J Mellbin, L Van Genechten, G Jankowski, P Vervaet, P Lemaitre, K Tuomilehto, J Reiner, Z Lehto, S Rydén, L De Smedt, D Badariene, J Marques-Vidal, P De Backer, G Grobbee, D E Larras, F Tsioufis, K Dzerve, V Ferreira, T Heuschmann, P Willems, A M Lovic, D Iglica, A Druais, H Kotseva, K Jennings, C Huyberechts, D Bruthans, J Bacquer, D De Oganov, R Maggioni, A Mommen, N Tokgözoğlu, L Abreu, A Dolzhenko, M Fiorucci, E Gotcheva, N Mancas, S Bollen, J Davletov, K Maggioni, A P Castro Conde, A |
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School, Hippokrateio Hospital, Athens, Greece – sequence: 56 givenname: D surname: Vulic fullname: Vulic, D organization: Faculty of Medicine, Banja Luka, Bosnia and Herzegovina – sequence: 57 givenname: D A surname: Wood fullname: Wood, D A organization: Cardiovascular Medicine, National Heart and Lung Institute, Medical Faculty, Imperial College London, London, UK – sequence: 58 givenname: K surname: Kotseva fullname: Kotseva, K organization: Cardiovascular Medicine, National Heart and Lung Institute, Medical Faculty, Imperial College London, London, UK – sequence: 59 givenname: C surname: Jennings fullname: Jennings, C organization: Cardiovascular Medicine, National Heart and Lung Institute, Medical Faculty, Imperial College London, London, UK – sequence: 60 givenname: A surname: Adamska fullname: Adamska, A organization: Cardiovascular Medicine, National Heart and Lung Institute, Medical Faculty, Imperial College London, London, UK – sequence: 61 givenname: S surname: Adamska 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fullname: Glemot, M organization: EURObservational Research Programme Department, European Heart House, Sophia Antipolis, Nice, France – sequence: 68 givenname: F surname: Larras fullname: Larras, F organization: EURObservational Research Programme Department, European Heart House, Sophia Antipolis, Nice, France – sequence: 69 givenname: V surname: Missiamenou fullname: Missiamenou, V organization: EURObservational Research Programme Department, European Heart House, Sophia Antipolis, Nice, France – sequence: 70 givenname: A surname: Maggioni fullname: Maggioni, A organization: EURObservational Research Programme Department, European Heart House, Sophia Antipolis, Nice, France – sequence: 71 givenname: C surname: Taylor fullname: Taylor, C organization: EURObservational Research Programme Department, European Heart House, Sophia Antipolis, Nice, France – sequence: 72 givenname: T surname: Ferreira fullname: Ferreira, T organization: EURObservational Research Programme Department, 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organization: University Hospital Gent, Belgium – sequence: 80 givenname: P surname: Vervaet fullname: Vervaet, P organization: University Hospital Gent, Belgium – sequence: 81 givenname: J surname: Bollen fullname: Bollen, J organization: Jessa Ziekenhuis, Hasselt, Belgium – sequence: 82 givenname: E surname: Dekimpe fullname: Dekimpe, E organization: Jessa Ziekenhuis, Hasselt, Belgium – sequence: 83 givenname: N surname: Mommen fullname: Mommen, N organization: Jessa Ziekenhuis, Hasselt, Belgium – sequence: 84 givenname: G surname: Van Genechten fullname: Van Genechten, G organization: Jessa Ziekenhuis, Hasselt, Belgium – sequence: 85 givenname: P surname: Dendale fullname: Dendale, P organization: Heart Centre Hasselt and Hasselt University, Belgium – sequence: 86 givenname: C A surname: Bouvier fullname: Bouvier, C A organization: Liniques Universitaires Saint Luc, Bruxelles, Belgium – sequence: 87 givenname: P surname: Chenu fullname: Chenu, P organization: Liniques Universitaires Saint Luc, Bruxelles, Belgium – sequence: 88 givenname: D surname: Huyberechts fullname: Huyberechts, D organization: Liniques Universitaires Saint Luc, Bruxelles, Belgium – sequence: 89 givenname: A surname: Persu fullname: Persu, A organization: Liniques Universitaires Saint Luc, Bruxelles, Belgium – sequence: 90 givenname: M surname: Dilic fullname: Dilic, M organization: Clinical Centre University of Sarajevo, Bosnia and Herzegovina – sequence: 91 givenname: A surname: Begic fullname: Begic, A organization: Clinical Centre University of Sarajevo, Bosnia and Herzegovina – sequence: 92 givenname: A surname: Durak Nalbantic fullname: Durak Nalbantic, A organization: Clinical Centre University of Sarajevo, Bosnia and Herzegovina – sequence: 93 givenname: A surname: Dzubur fullname: Dzubur, A organization: Clinical Centre University of Sarajevo, Bosnia and Herzegovina – sequence: 94 givenname: N surname: Hadzibegic fullname: Hadzibegic, N organization: Clinical Centre University of Sarajevo, Bosnia and Herzegovina – sequence: 95 givenname: A surname: Iglica fullname: Iglica, A organization: Clinical Centre University of Sarajevo, Bosnia and Herzegovina – sequence: 96 givenname: S surname: Kapidjic fullname: Kapidjic, S organization: Clinical Centre University of Sarajevo, Bosnia and Herzegovina |
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| Keywords | LDL-Cholesterol EUROASPIRE Secondary prevention Lipid lowering therapy Dyslipidaemia Coronary heart disease |
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| Title | Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries |
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