Monounsaturated fatty acids promote cancer radioresistance by inhibiting ferroptosis through ACSL3

Radioresistance is a major challenge in tumor radiotherapy and involves in a mixture of cellular events, including ferroptosis, a new type of programmed cell death characterized by the excess accumulation of iron-dependent lipid peroxides. In the present study, we observed that surviving cancer tiss...

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Veröffentlicht in:	Cell death & disease Jg. 16; H. 1; S. 184 - 13
Hauptverfasser:	Cao, Yulin, Li, Jiuming, Chen, Ying, Wang, Yuanben, Liu, Zhiang, Huang, Liuying, Liu, Bingxin, Feng, Yuyang, Yao, Surui, Zhou, Leyuan, Yin, Yuan, Huang, Zhaohui
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 18.03.2025 Springer Nature B.V Nature Publishing Group
Schlagworte:	13/51 14/28 631/67/395 64/60 692/699/67/1059/2326 692/699/67/1059/485 692/699/67/1504/1885/1777 82/58 82/80 82/81 Animals Antibodies Antitumor activity Apoptosis Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Culture Cell death Cell Line, Tumor Coenzyme A Ligases - genetics Coenzyme A Ligases - metabolism Fatty acids Fatty Acids, Monounsaturated - metabolism Fatty Acids, Monounsaturated - pharmacology Female Ferroptosis Ferroptosis - drug effects Ferroptosis - radiation effects Glutathione Humans Imidazole Immunology Life Sciences Lipids Long-Chain-Fatty-Acid-CoA Ligase Mice Mice, Nude Neoplasms - metabolism Neoplasms - pathology Neoplasms - radiotherapy Oleic acid Oleic Acid - pharmacology Palmitoleic acid Phospholipids Piperazines - pharmacology Polyunsaturated fatty acids Radiation therapy Radiation Tolerance - drug effects Radioresistance Reactive oxygen species Reactive Oxygen Species - metabolism Tumors
ISSN:	2041-4889, 2041-4889
Online-Zugang:	Volltext
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