Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE

In vivo, ectopic accumulation of fatty acids in muscles leads to alterations in insulin signaling at both the IRS1 and Akt steps. However, in vitro treatments with saturated fatty acids or their derivative ceramide demonstrate an effect only at the Akt step. In this study, we adapted our experimenta...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 291; no. 6; p. 3019
Main Authors:	Hage Hassan, Rima, Pacheco de Sousa, Ana Catarina, Mahfouz, Rana, Hainault, Isabelle, Blachnio-Zabielska, Agnieszka, Bourron, Olivier, Koskas, Fabien, Górski, Jan, Ferré, Pascal, Foufelle, Fabienne, Hajduch, Eric
Format:	Journal Article
Language:	English
Published:	United States 05.02.2016
Subjects:	Animals Cell Line Ceramides - genetics Ceramides - metabolism eIF-2 Kinase - genetics eIF-2 Kinase - metabolism Humans Insulin - genetics Insulin - metabolism Insulin Receptor Substrate Proteins - genetics Insulin Receptor Substrate Proteins - metabolism Insulin Resistance - physiology Male MAP Kinase Kinase 4 - genetics MAP Kinase Kinase 4 - metabolism Mice Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Phosphorylation Proto-Oncogene Proteins c-akt Signal Transduction - physiology protein kinase RNA-activated (PKR) ceramide insulin signaling type 2 diabetes Akt PKB skeletal muscle
ISSN:	1083-351X, 1083-351X
Online Access:	Get more information
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