Short Term Palmitate Supply Impairs Intestinal Insulin Signaling via Ceramide Production

The worldwide prevalence of metabolic diseases is increasing, and there are global recommendations to limit consumption of certain nutrients, especially saturated lipids. Insulin resistance, a common trait occurring in obesity and type 2 diabetes, is associated with intestinal lipoprotein overproduc...

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Veröffentlicht in:	The Journal of biological chemistry Jg. 291; H. 31; S. 16328
Hauptverfasser:	Tran, Thi Thu Trang, Postal, Bárbara Graziela, Demignot, Sylvie, Ribeiro, Agnès, Osinski, Céline, Pais de Barros, Jean-Paul, Blachnio-Zabielska, Agnieszka, Leturque, Armelle, Rousset, Monique, Ferré, Pascal, Hajduch, Eric, Carrière, Véronique
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 29.07.2016
Schlagworte:	Animals Caco-2 Cells Ceramides - biosynthesis Enterocytes - metabolism Humans Insulin - metabolism Intestinal Mucosa - metabolism Mice Palm Oil Palmitic Acid - metabolism Palmitic Acid - pharmacology Phosphorylation - drug effects Plant Oils - pharmacology Proto-Oncogene Proteins c-akt - metabolism Signal Transduction ceramide intestine signaling insulin fatty acid Akt PKB lipid palmitic acid
ISSN:	1083-351X, 1083-351X
Online-Zugang:	Weitere Angaben
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