Cells respond to mechanical stress by rapid disassembly of caveolae

The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretchin...

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Vydáno v:	Cell Ročník 144; číslo 3; s. 402
Hlavní autoři:	Sinha, Bidisha, Köster, Darius, Ruez, Richard, Gonnord, Pauline, Bastiani, Michele, Abankwa, Daniel, Stan, Radu V, Butler-Browne, Gillian, Vedie, Benoit, Johannes, Ludger, Morone, Nobuhiro, Parton, Robert G, Raposo, Graça, Sens, Pierre, Lamaze, Christophe, Nassoy, Pierre
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 04.02.2011
Témata:	Actins - physiology Adenosine Triphosphate - physiology Animals Caveolae - physiology Caveolae - ultrastructure Cell Line Endothelial Cells - cytology Endothelial Cells - physiology Humans Mice Muscle Cells - cytology Muscle Cells - physiology Stress, Mechanical
ISSN:	1097-4172, 1097-4172
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretching results in a rapid disappearance of caveolae, in a reduced caveolin/Cavin1 interaction, and in an increase of free caveolins at the plasma membrane. Tether-pulling force measurements in cells and in plasma membrane spheres demonstrate that caveola flattening and disassembly is the primary actin- and ATP-independent cell response that buffers membrane tension surges during mechanical stress. Conversely, stress release leads to complete caveola reassembly in an actin- and ATP-dependent process. The absence of a functional caveola reservoir in myotubes from muscular dystrophic patients enhanced membrane fragility under mechanical stress. Our findings support a new role for caveolae as a physiological membrane reservoir that quickly accommodates sudden and acute mechanical stresses.
AbstractList	The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretching results in a rapid disappearance of caveolae, in a reduced caveolin/Cavin1 interaction, and in an increase of free caveolins at the plasma membrane. Tether-pulling force measurements in cells and in plasma membrane spheres demonstrate that caveola flattening and disassembly is the primary actin- and ATP-independent cell response that buffers membrane tension surges during mechanical stress. Conversely, stress release leads to complete caveola reassembly in an actin- and ATP-dependent process. The absence of a functional caveola reservoir in myotubes from muscular dystrophic patients enhanced membrane fragility under mechanical stress. Our findings support a new role for caveolae as a physiological membrane reservoir that quickly accommodates sudden and acute mechanical stresses.The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretching results in a rapid disappearance of caveolae, in a reduced caveolin/Cavin1 interaction, and in an increase of free caveolins at the plasma membrane. Tether-pulling force measurements in cells and in plasma membrane spheres demonstrate that caveola flattening and disassembly is the primary actin- and ATP-independent cell response that buffers membrane tension surges during mechanical stress. Conversely, stress release leads to complete caveola reassembly in an actin- and ATP-dependent process. The absence of a functional caveola reservoir in myotubes from muscular dystrophic patients enhanced membrane fragility under mechanical stress. Our findings support a new role for caveolae as a physiological membrane reservoir that quickly accommodates sudden and acute mechanical stresses. The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretching results in a rapid disappearance of caveolae, in a reduced caveolin/Cavin1 interaction, and in an increase of free caveolins at the plasma membrane. Tether-pulling force measurements in cells and in plasma membrane spheres demonstrate that caveola flattening and disassembly is the primary actin- and ATP-independent cell response that buffers membrane tension surges during mechanical stress. Conversely, stress release leads to complete caveola reassembly in an actin- and ATP-dependent process. The absence of a functional caveola reservoir in myotubes from muscular dystrophic patients enhanced membrane fragility under mechanical stress. Our findings support a new role for caveolae as a physiological membrane reservoir that quickly accommodates sudden and acute mechanical stresses.
Author	Sinha, Bidisha Morone, Nobuhiro Nassoy, Pierre Butler-Browne, Gillian Parton, Robert G Köster, Darius Raposo, Graça Gonnord, Pauline Ruez, Richard Johannes, Ludger Sens, Pierre Abankwa, Daniel Lamaze, Christophe Vedie, Benoit Stan, Radu V Bastiani, Michele
Author_xml	– sequence: 1 givenname: Bidisha surname: Sinha fullname: Sinha, Bidisha organization: Université P. et M. Curie/CNRS UMR, Paris, France – sequence: 2 givenname: Darius surname: Köster fullname: Köster, Darius – sequence: 3 givenname: Richard surname: Ruez fullname: Ruez, Richard – sequence: 4 givenname: Pauline surname: Gonnord fullname: Gonnord, Pauline – sequence: 5 givenname: Michele surname: Bastiani fullname: Bastiani, Michele – sequence: 6 givenname: Daniel surname: Abankwa fullname: Abankwa, Daniel – sequence: 7 givenname: Radu V surname: Stan fullname: Stan, Radu V – sequence: 8 givenname: Gillian surname: Butler-Browne fullname: Butler-Browne, Gillian – sequence: 9 givenname: Benoit surname: Vedie fullname: Vedie, Benoit – sequence: 10 givenname: Ludger surname: Johannes fullname: Johannes, Ludger – sequence: 11 givenname: Nobuhiro surname: Morone fullname: Morone, Nobuhiro – sequence: 12 givenname: Robert G surname: Parton fullname: Parton, Robert G – sequence: 13 givenname: Graça surname: Raposo fullname: Raposo, Graça – sequence: 14 givenname: Pierre surname: Sens fullname: Sens, Pierre – sequence: 15 givenname: Christophe surname: Lamaze fullname: Lamaze, Christophe – sequence: 16 givenname: Pierre surname: Nassoy fullname: Nassoy, Pierre
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/21295700$$D View this record in MEDLINE/PubMed
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Snippet	The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to...
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SubjectTerms	Actins - physiology Adenosine Triphosphate - physiology Animals Caveolae - physiology Caveolae - ultrastructure Cell Line Endothelial Cells - cytology Endothelial Cells - physiology Humans Mice Muscle Cells - cytology Muscle Cells - physiology Stress, Mechanical
Title	Cells respond to mechanical stress by rapid disassembly of caveolae
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