A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage

Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, str...

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Vydáno v:	Nature communications Ročník 16; číslo 1; s. 5782 - 17
Hlavní autoři:	Huang, Xingcan, Zhang, Qiang, Yang, Yawen, Chow, Lung, Ma, Jie, Xu, Guoqiang, Guo, Fang, He, Xinxin, Li, Zhiyuan, Zhao, Guangyao, Su, Jingyou, Guo, Guihuan, Wang, Jiachen, Jiao, Yanli, Gao, Zhan, Li, Jiyu, Zhou, Jingkun, Yiu, Chun Ki, Li, Jian, Chen, Yi, Wu, Pengcheng, Yao, Kuanming, Liu, Yiming, Li, Dengfeng, Zhang, Binbin, Chu, Hongwei, Hu, Yue, Huang, Ya, Chen, Zhenlin, Ren, Kangning, Fang, Bo, Yang, Rungong, Li, Heng, Tao, Xiaoming, Ma, Xiaohui, Yu, Xinge
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.07.2025 Nature Publishing Group Nature Portfolio
Témata:	142/126 639/166/985 639/166/987 639/166/988 639/301/923 692/700 9/10 Adhesion Adhesives Adolescent Adult Aged Aged, 80 and over Animals Bandages Biomaterials Biomedical materials Biosensors Clinical trials Closed loops Diabetes Electronics Female Glucose Humanities and Social Sciences Humans In vivo methods and tests Infections Male Medical dressings Mice Middle Aged Monitoring multidisciplinary Permeability Real time Science Science (multidisciplinary) Skin Skin - injuries Smartphones Waterproofing Wireless communications Wound healing Wound Healing - physiology Young Adult
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management. Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-025-61261-8