Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes

Sohrab Shah, David Huntsman and colleagues report the genomic analysis of 133 ovarian cancers spanning different subtypes. They identify seven subgroups using point mutation and structural variation signatures and use these genomic features to stratify ovarian cancers both between and within histoty...

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Published in:	Nature genetics Vol. 49; no. 6; pp. 856 - 865
Main Authors:	Wang, Yi Kan, Bashashati, Ali, Anglesio, Michael S, Cochrane, Dawn R, Grewal, Diljot S, Ha, Gavin, McPherson, Andrew, Horlings, Hugo M, Senz, Janine, Prentice, Leah M, Karnezis, Anthony N, Lai, Daniel, Aniba, Mohamed R, Zhang, Allen W, Shumansky, Karey, Siu, Celia, Wan, Adrian, McConechy, Melissa K, Li-Chang, Hector, Tone, Alicia, Provencher, Diane, de Ladurantaye, Manon, Fleury, Hubert, Okamoto, Aikou, Yanagida, Satoshi, Yanaihara, Nozomu, Saito, Misato, Mungall, Andrew J, Moore, Richard, Marra, Marco A, Gilks, C Blake, Mes-Masson, Anne-Marie, McAlpine, Jessica N, Aparicio, Samuel, Huntsman, David G, Shah, Sohrab P
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.06.2017 Nature Publishing Group
Subjects:	45/77 49/39 631/114/2785 631/67/1517/1709 Aberration Age Agriculture Animal Genetics and Genomics Biomarkers Biomedicine BRCA1 protein BRCA1 Protein - genetics BRCA2 protein BRCA2 Protein - genetics Breast cancer Cancer Cancer Research Care and treatment Clustering Colleges & universities Deamination Deoxyribonucleic acid Development and progression DNA DNA methylation DNA repair DNA Repair - genetics Endometriosis - complications Endometriosis - genetics Female Gene expression Gene Expression Regulation, Neoplastic Gene Function Genetic aspects Genetic testing Genome, Human Genomes Gynecology Health aspects Human Genetics Humans Inversions Medical screening Medicine Microsatellite instability Mutation Obstetrics Oncology Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Point mutation Prognosis Repair Signatures Stability Strata Stratigraphy Subgroups Survival Trends Tumors Canada
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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