Comparative analysis of organoid, air-liquid interface, and direct infection models for studying pathogen–host interactions in endometrial tissue

The endometrium is a critical component of female reproductive health. Endometritis can significantly affect women’s health, leading to complications such as infertility, pregnancy failure, and intrauterine adhesions. Therefore, establishing a reliable and effective model of endometritis is essentia...

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Bibliographic Details
Published in:	Scientific reports Vol. 15; no. 1; pp. 8531 - 11
Main Authors:	Zhang, Xin, Fan, Linyuan, Zhang, Li, Liu, Zhaohui
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12.03.2025 Nature Publishing Group Nature Portfolio
Subjects:	631/1647/2204 631/1647/767 692/699/255 Air-liquid interface Animals Cell culture Comparative analysis E coli Endometrial organoids Endometritis Endometritis - microbiology Endometritis - pathology Endometrium Endometrium - microbiology Endometrium - pathology Escherichia coli - pathogenicity Escherichia coli Infections - microbiology Escherichia coli Infections - pathology Female Females Host-Pathogen Interactions Humanities and Social Sciences Humans Immune response Infection model Infections Infertility Microinjection Microinjections Models, Biological multidisciplinary Organoids Organoids - microbiology Pregnancy complications Replication Reproductive health Science Science (multidisciplinary) Suspension culture Transwell Endometrial organoids Air-liquid interface Infection model Transwell
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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