Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection

Severe influenza A virus (IAV) infections are associated with hyperinflammation and significant lung damage. Gasdermin E (GSDME) mediates pyroptosis, a lytic and inflammatory type of cell death. Cleavage of GSDME by caspase-3 releases the active N-terminal domain, which subsequently forms transmembr...

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Veröffentlicht in:	Cell death & disease Jg. 16; H. 1; S. 440 - 13
Hauptverfasser:	Rosli, Sarah, Ambrose, Rebecca L., Harpur, Christopher M., Lam, Maggie, Hodges, Christopher, Barry, Kristian T., West, Alison C., Mansell, Ashley, Lawlor, Kate E., Tate, Michelle D.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 06.06.2025 Springer Nature B.V Nature Publishing Group
Schlagworte:	13/21 14/19 631/250/255/1578 631/250/256/2516 64/60 82/51 82/80 96 96/106 96/31 96/63 Animals Antibodies Biochemistry Biomedical and Life Sciences Caspase 3 - metabolism Caspase-3 Cell Biology Cell Culture Cell death Disease resistance E-cadherin Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial Cells - virology Gasdermins Humans Immunology Infections Inflammation - pathology Influenza Influenza A Influenza A virus - pathogenicity Influenza, Human - pathology Influenza, Human - virology Interleukin 6 Leukocytes (neutrophilic) Life Sciences Lung - metabolism Lung - pathology Lung - virology Mice Mice, Inbred C57BL Mice, Knockout Orthomyxoviridae Infections - genetics Orthomyxoviridae Infections - metabolism Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - virology Pathogenesis Phosphate-Binding Proteins - deficiency Pyroptosis siRNA γ-Interferon
ISSN:	2041-4889, 2041-4889
Online-Zugang:	Volltext
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