Unveiling the hidden interactome of CRBN molecular glues

Induced proximity by molecular glues refers to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or degradation. As prospective design of molecular glues remains challenging, unbiased discovery methods are necessary to discover new chemical targets. He...

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Veröffentlicht in:	Nature communications Jg. 16; H. 1; S. 6831 - 18
Hauptverfasser:	Baek, Kheewoong, Metivier, Rebecca J., Roy Burman, Shourya S., Bushman, Jonathan W., Yoon, Hojong, Lumpkin, Ryan J., Ryan, Julia K., Abeja, Dinah M., Lakshminarayan, Megha, Yue, Hong, Ojeda, Samuel, Xiong, Yuan, Che, Jianwei, Verano, Alyssa L., Schmoker, Anna M., Gray, Nathanael S., Donovan, Katherine A., Fischer, Eric S.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 24.07.2025 Nature Publishing Group Nature Portfolio
Schlagworte:	101/28 13 13/1 13/106 49/56 631/45/475/2290 631/92/507 82/16 82/47 82/58 82/80 82/83 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adhesives Biochemistry Computer applications Degradation Glues HEK293 Cells Humanities and Social Sciences Humans Identification Kinases Lead compounds Lysates multidisciplinary Peptide mapping Protein Binding Protein interaction Proteins Proteomics Proteomics - methods Science Science (multidisciplinary) Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Workflow Zinc finger proteins
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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