Abundant pleiotropy in human complex diseases and traits

We present a systematic review of pleiotropy among SNPs and genes reported to show genome-wide association with common complex diseases and traits. We find abundant evidence of pleiotropy; 233 (16.9%) genes and 77 (4.6%) SNPs show pleiotropic effects. SNP pleiotropic status was associated with gene...

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Veröffentlicht in:	American journal of human genetics Jg. 89; H. 5; S. 607
Hauptverfasser:	Sivakumaran, Shanya, Agakov, Felix, Theodoratou, Evropi, Prendergast, James G, Zgaga, Lina, Manolio, Teri, Rudan, Igor, McKeigue, Paul, Wilson, James F, Campbell, Harry
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 11.11.2011
Schlagworte:	Databases, Genetic Disease - genetics Genetic Pleiotropy - genetics Genetic Predisposition to Disease Genetics, Population Genome, Human Genome-Wide Association Study Humans Models, Genetic Polymorphism, Single Nucleotide Quantitative Trait Loci - genetics
ISSN:	1537-6605, 1537-6605
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