Mitochondrial DNA in extracellular vesicles declines with age

The mitochondrial free radical theory of aging suggests that accumulating oxidative damage to mitochondria and mitochondrial DNA (mtDNA) plays a central role in aging. Circulating cell‐free mtDNA (ccf‐mtDNA) isolated from blood may be a biomarker of disease. Extracellular vesicles (EVs) are small (3...

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Bibliographic Details
Published in:	Aging cell Vol. 20; no. 1; pp. e13283 - n/a
Main Authors:	Lazo, Stephanie, Noren Hooten, Nicole, Green, Jamal, Eitan, Erez, Mode, Nicolle A., Liu, Qing‐Rong, Zonderman, Alan B., Ezike, Ngozi, Mattson, Mark P., Ghosh, Paritosh, Evans, Michele K.
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.01.2021 John Wiley and Sons Inc
Subjects:	Age Aging Analysis B cells biomarker Breast cancer Cell signaling circulating cell‐free mitochondrial DNA Communications systems Deoxyribonucleic acid Design DNA exosomes Extracellular vesicles Genes Genomes intercellular communication Lipids Microscopy microvesicles Mitochondrial DNA Morphology Nanoparticles Older people Original Physiology Plasma Protein binding Proteins extracellular vesicles exosomes mitochondrial DNA intercellular communication aging microvesicles biomarker circulating cell-free mitochondrial DNA
ISSN:	1474-9718, 1474-9726, 1474-9726
Online Access:	Get full text
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