Mitochondrial DNA in extracellular vesicles declines with age

The mitochondrial free radical theory of aging suggests that accumulating oxidative damage to mitochondria and mitochondrial DNA (mtDNA) plays a central role in aging. Circulating cell‐free mtDNA (ccf‐mtDNA) isolated from blood may be a biomarker of disease. Extracellular vesicles (EVs) are small (3...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Aging cell Ročník 20; číslo 1; s. e13283 - n/a
Hlavní autori:	Lazo, Stephanie, Noren Hooten, Nicole, Green, Jamal, Eitan, Erez, Mode, Nicolle A., Liu, Qing‐Rong, Zonderman, Alan B., Ezike, Ngozi, Mattson, Mark P., Ghosh, Paritosh, Evans, Michele K.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England John Wiley & Sons, Inc 01.01.2021 John Wiley and Sons Inc
Predmet:	Age Aging Analysis B cells biomarker Breast cancer Cell signaling circulating cell‐free mitochondrial DNA Communications systems Deoxyribonucleic acid Design DNA exosomes Extracellular vesicles Genes Genomes intercellular communication Lipids Microscopy microvesicles Mitochondrial DNA Morphology Nanoparticles Older people Original Physiology Plasma Protein binding Proteins extracellular vesicles exosomes mitochondrial DNA intercellular communication aging microvesicles biomarker circulating cell-free mitochondrial DNA
ISSN:	1474-9718, 1474-9726, 1474-9726
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	The mitochondrial free radical theory of aging suggests that accumulating oxidative damage to mitochondria and mitochondrial DNA (mtDNA) plays a central role in aging. Circulating cell‐free mtDNA (ccf‐mtDNA) isolated from blood may be a biomarker of disease. Extracellular vesicles (EVs) are small (30–400 nm), lipid‐bound vesicles capable of shuttling proteins, nucleic acids, and lipids as part of intercellular communication systems. Here, we report that a portion of ccf‐mtDNA in plasma is encapsulated in EVs. To address whether EV mtDNA levels change with human age, we analyzed mtDNA in EVs from individuals aged 30–64 years cross‐sectionally and longitudinally. EV mtDNA levels decreased with age. Furthermore, the maximal mitochondrial respiration of cultured cells was differentially affected by EVs from old and young donors. Our results suggest that plasma mtDNA is present in EVs, that the level of EV‐derived mtDNA is associated with age, and that EVs affect mitochondrial energetics in an EV age‐dependent manner. Mitochondrial dysfunction plays a central role in aging. A portion of circulating cell‐free mitochondrial DNA (mtDNA) isolated from blood is present in extracellular vesicles (EVs), which are small, lipid‐bound vesicles that shuttle macromolecules as part of intercellular communication systems. The level of EV‐derived mtDNA declines with age, and these EVs affect mitochondrial energetics in an EV age‐dependent manner.
AbstractList	The mitochondrial free radical theory of aging suggests that accumulating oxidative damage to mitochondria and mitochondrial DNA (mtDNA) plays a central role in aging. Circulating cell‐free mtDNA (ccf‐mtDNA) isolated from blood may be a biomarker of disease. Extracellular vesicles (EVs) are small (30–400 nm), lipid‐bound vesicles capable of shuttling proteins, nucleic acids, and lipids as part of intercellular communication systems. Here, we report that a portion of ccf‐mtDNA in plasma is encapsulated in EVs. To address whether EV mtDNA levels change with human age, we analyzed mtDNA in EVs from individuals aged 30–64 years cross‐sectionally and longitudinally. EV mtDNA levels decreased with age. Furthermore, the maximal mitochondrial respiration of cultured cells was differentially affected by EVs from old and young donors. Our results suggest that plasma mtDNA is present in EVs, that the level of EV‐derived mtDNA is associated with age, and that EVs affect mitochondrial energetics in an EV age‐dependent manner. Mitochondrial dysfunction plays a central role in aging. A portion of circulating cell‐free mitochondrial DNA (mtDNA) isolated from blood is present in extracellular vesicles (EVs), which are small, lipid‐bound vesicles that shuttle macromolecules as part of intercellular communication systems. The level of EV‐derived mtDNA declines with age, and these EVs affect mitochondrial energetics in an EV age‐dependent manner. The mitochondrial free radical theory of aging suggests that accumulating oxidative damage to mitochondria and mitochondrial DNA (mtDNA) plays a central role in aging. Circulating cell‐free mtDNA (ccf‐mtDNA) isolated from blood may be a biomarker of disease. Extracellular vesicles (EVs) are small (30–400 nm), lipid‐bound vesicles capable of shuttling proteins, nucleic acids, and lipids as part of intercellular communication systems. Here, we report that a portion of ccf‐mtDNA in plasma is encapsulated in EVs. To address whether EV mtDNA levels change with human age, we analyzed mtDNA in EVs from individuals aged 30–64 years cross‐sectionally and longitudinally. EV mtDNA levels decreased with age. Furthermore, the maximal mitochondrial respiration of cultured cells was differentially affected by EVs from old and young donors. Our results suggest that plasma mtDNA is present in EVs, that the level of EV‐derived mtDNA is associated with age, and that EVs affect mitochondrial energetics in an EV age‐dependent manner. The mitochondrial free radical theory of aging suggests that accumulating oxidative damage to mitochondria and mitochondrial DNA (mtDNA) plays a central role in aging. Circulating cell‐free mtDNA (ccf‐mtDNA) isolated from blood may be a biomarker of disease. Extracellular vesicles (EVs) are small (30–400 nm), lipid‐bound vesicles capable of shuttling proteins, nucleic acids, and lipids as part of intercellular communication systems. Here, we report that a portion of ccf‐mtDNA in plasma is encapsulated in EVs. To address whether EV mtDNA levels change with human age, we analyzed mtDNA in EVs from individuals aged 30–64 years cross‐sectionally and longitudinally. EV mtDNA levels decreased with age. Furthermore, the maximal mitochondrial respiration of cultured cells was differentially affected by EVs from old and young donors. Our results suggest that plasma mtDNA is present in EVs, that the level of EV‐derived mtDNA is associated with age, and that EVs affect mitochondrial energetics in an EV age‐dependent manner. The mitochondrial free radical theory of aging suggests that accumulating oxidative damage to mitochondria and mitochondrial DNA (mtDNA) plays a central role in aging. Circulating cell-free mtDNA (ccf-mtDNA) isolated from blood may be a biomarker of disease. Extracellular vesicles (EVs) are small (30-400 nm), lipid-bound vesicles capable of shuttling proteins, nucleic acids, and lipids as part of intercellular communication systems. Here, we report that a portion of ccf-mtDNA in plasma is encapsulated in EVs. To address whether EV mtDNA levels change with human age, we analyzed mtDNA in EVs from individuals aged 30-64 years cross-sectionally and longitudinally. EV mtDNA levels decreased with age. Furthermore, the maximal mitochondrial respiration of cultured cells was differentially affected by EVs from old and young donors. Our results suggest that plasma mtDNA is present in EVs, that the level of EV-derived mtDNA is associated with age, and that EVs affect mitochondrial energetics in an EV age-dependent manner.The mitochondrial free radical theory of aging suggests that accumulating oxidative damage to mitochondria and mitochondrial DNA (mtDNA) plays a central role in aging. Circulating cell-free mtDNA (ccf-mtDNA) isolated from blood may be a biomarker of disease. Extracellular vesicles (EVs) are small (30-400 nm), lipid-bound vesicles capable of shuttling proteins, nucleic acids, and lipids as part of intercellular communication systems. Here, we report that a portion of ccf-mtDNA in plasma is encapsulated in EVs. To address whether EV mtDNA levels change with human age, we analyzed mtDNA in EVs from individuals aged 30-64 years cross-sectionally and longitudinally. EV mtDNA levels decreased with age. Furthermore, the maximal mitochondrial respiration of cultured cells was differentially affected by EVs from old and young donors. Our results suggest that plasma mtDNA is present in EVs, that the level of EV-derived mtDNA is associated with age, and that EVs affect mitochondrial energetics in an EV age-dependent manner. The mitochondrial free radical theory of aging suggests that accumulating oxidative damage to mitochondria and mitochondrial DNA (mtDNA) plays a central role in aging. Circulating cell‐free mtDNA (ccf‐mtDNA) isolated from blood may be a biomarker of disease. Extracellular vesicles (EVs) are small (30–400 nm), lipid‐bound vesicles capable of shuttling proteins, nucleic acids, and lipids as part of intercellular communication systems. Here, we report that a portion of ccf‐mtDNA in plasma is encapsulated in EVs. To address whether EV mtDNA levels change with human age, we analyzed mtDNA in EVs from individuals aged 30–64 years cross‐sectionally and longitudinally. EV mtDNA levels decreased with age. Furthermore, the maximal mitochondrial respiration of cultured cells was differentially affected by EVs from old and young donors. Our results suggest that plasma mtDNA is present in EVs, that the level of EV‐derived mtDNA is associated with age, and that EVs affect mitochondrial energetics in an EV age‐dependent manner. Mitochondrial dysfunction plays a central role in aging. A portion of circulating cell‐free mitochondrial DNA (mtDNA) isolated from blood is present in extracellular vesicles (EVs), which are small, lipid‐bound vesicles that shuttle macromolecules as part of intercellular communication systems. The level of EV‐derived mtDNA declines with age, and these EVs affect mitochondrial energetics in an EV age‐dependent manner.
Audience	Academic
Author	Evans, Michele K. Lazo, Stephanie Mattson, Mark P. Noren Hooten, Nicole Liu, Qing‐Rong Zonderman, Alan B. Ghosh, Paritosh Ezike, Ngozi Eitan, Erez Mode, Nicolle A. Green, Jamal
AuthorAffiliation	1 Laboratory of Epidemiology and Population Science National Institute on Aging National Institutes of Health Baltimore MD USA 2 Laboratory of Neuroscience National Institute on Aging National Institutes of Health Baltimore MD USA 3 Laboratory of Clinical Investigation, National Institute on Aging National Institutes of Health Baltimore MD USA 4 Present address: Perelman School of Medicine University of Pennsylvania Philadelphia PA USA 5 Present address: NeuroDex Natick MA USA
AuthorAffiliation_xml	– name: 4 Present address: Perelman School of Medicine University of Pennsylvania Philadelphia PA USA – name: 5 Present address: NeuroDex Natick MA USA – name: 2 Laboratory of Neuroscience National Institute on Aging National Institutes of Health Baltimore MD USA – name: 1 Laboratory of Epidemiology and Population Science National Institute on Aging National Institutes of Health Baltimore MD USA – name: 3 Laboratory of Clinical Investigation, National Institute on Aging National Institutes of Health Baltimore MD USA
Author_xml	– sequence: 1 givenname: Stephanie orcidid: 0000-0001-8016-3181 surname: Lazo fullname: Lazo, Stephanie organization: National Institutes of Health – sequence: 2 givenname: Nicole orcidid: 0000-0002-1683-3838 surname: Noren Hooten fullname: Noren Hooten, Nicole organization: National Institutes of Health – sequence: 3 givenname: Jamal surname: Green fullname: Green, Jamal organization: National Institutes of Health – sequence: 4 givenname: Erez surname: Eitan fullname: Eitan, Erez organization: National Institutes of Health – sequence: 5 givenname: Nicolle A. surname: Mode fullname: Mode, Nicolle A. organization: National Institutes of Health – sequence: 6 givenname: Qing‐Rong surname: Liu fullname: Liu, Qing‐Rong organization: National Institutes of Health – sequence: 7 givenname: Alan B. surname: Zonderman fullname: Zonderman, Alan B. organization: National Institutes of Health – sequence: 8 givenname: Ngozi surname: Ezike fullname: Ezike, Ngozi organization: National Institutes of Health – sequence: 9 givenname: Mark P. surname: Mattson fullname: Mattson, Mark P. organization: National Institutes of Health – sequence: 10 givenname: Paritosh surname: Ghosh fullname: Ghosh, Paritosh organization: National Institutes of Health – sequence: 11 givenname: Michele K. orcidid: 0000-0002-8546-2831 surname: Evans fullname: Evans, Michele K. email: me42v@nih.gov organization: National Institutes of Health
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/33355987$$D View this record in MEDLINE/PubMed
BookMark	eNqFkl1vFCEUhompsR964w8wk3hjmuwKw-dcaLJZ60ey6o1eE4Y5s0vDQoWZ1v77Mm7dtE2jcMEJPOfl8B6O0UGIARB6SfCclPHWWPBzQmtFn6AjwiSbNbIWB_uYqEN0nPM5xkQ2mD5Dh5RSzhslj9C7r26IdhNDl5zx1Ydvi8qFCn4PaVL1ozepuoTsrIdcdWC9CyW4csOmMmt4jp72xmd4cbueoJ8fz34sP89W3z99WS5WM8sZpTOioBWs4UQYK0BBw6AUgDuBO6XqDhSxXELbMSZ43_Le1J0gtbCCcsa4bekJer_TvRjbLXQWQqnP64vktiZd62icvn8S3Eav46WWihDFeBF4cyuQ4q8R8qC3Lk8PNAHimHXNJGU1qaUo6OsH6HkcUyjPmyhV6maY_pdixfY71Np40C70cfJ1ulovJOayaShtCjV_hCqzg62zpde9K_v3El7dtWPvw9-2FuB0B9gUc07Q7xGC9fRn9NRd_efPFBg_gK0bzODiZKXzj6eQXcpVqez6H-J6sTxb7XJuAIm40CA
CitedBy_id	crossref_primary_10_3390_life12040546 crossref_primary_10_1002_jex2_65 crossref_primary_10_1186_s43556_025_00305_3 crossref_primary_10_1016_j_biochi_2022_01_002 crossref_primary_10_3390_ijms26125481 crossref_primary_10_1016_j_bbamcr_2022_119326 crossref_primary_10_1097_PSY_0000000000001254 crossref_primary_10_1038_s41598_022_17944_z crossref_primary_10_1016_j_heliyon_2024_e24751 crossref_primary_10_1111_boc_202200116 crossref_primary_10_4103_NRR_NRR_D_24_00665 crossref_primary_10_1002_jex2_70069 crossref_primary_10_1186_s12967_023_04133_3 crossref_primary_10_3389_fmolb_2023_1156821 crossref_primary_10_3390_cells10123331 crossref_primary_10_3390_cells11050836 crossref_primary_10_3390_ijms26157245 crossref_primary_10_1016_j_exphem_2021_08_004 crossref_primary_10_1186_s13578_025_01456_0 crossref_primary_10_3389_fimmu_2022_949451 crossref_primary_10_3390_cells13060495 crossref_primary_10_1186_s40364_024_00661_2 crossref_primary_10_1111_jnc_16108 crossref_primary_10_1016_j_ebiom_2024_105065 crossref_primary_10_1016_j_jad_2024_06_092 crossref_primary_10_3389_fmolb_2022_840364 crossref_primary_10_1186_s11658_024_00669_4 crossref_primary_10_1186_s12979_023_00330_2 crossref_primary_10_1016_j_mad_2025_112078 crossref_primary_10_3390_ijms25052818 crossref_primary_10_1016_j_mad_2025_112112 crossref_primary_10_3390_cells13010095 crossref_primary_10_1016_j_arr_2021_101536 crossref_primary_10_1016_j_jconrel_2022_08_010 crossref_primary_10_3390_ijms22115846 crossref_primary_10_3390_jcm14186528 crossref_primary_10_3390_ijms24032637 crossref_primary_10_3390_diagnostics12092147 crossref_primary_10_1016_j_jad_2024_03_113 crossref_primary_10_1093_intimm_dxae052 crossref_primary_10_1111_jcmm_70559 crossref_primary_10_3390_cells12040527 crossref_primary_10_1016_j_arr_2024_102522 crossref_primary_10_3390_membranes12060552 crossref_primary_10_1016_j_scib_2024_10_013 crossref_primary_10_3390_ijms241210294 crossref_primary_10_1016_j_jnha_2023_100013 crossref_primary_10_1111_acel_70029 crossref_primary_10_1186_s12967_024_05250_3 crossref_primary_10_1002_jcp_31331 crossref_primary_10_1002_jev2_12398 crossref_primary_10_1080_17425247_2023_2279115 crossref_primary_10_3390_ijms232214098 crossref_primary_10_1186_s12950_022_00315_w crossref_primary_10_3390_ijms241814163 crossref_primary_10_1038_s41598_022_14211_z crossref_primary_10_1186_s12974_024_03230_4 crossref_primary_10_3390_antiox14020177 crossref_primary_10_3892_ijmm_2022_5182 crossref_primary_10_1113_JP286224 crossref_primary_10_1146_annurev_biochem_032620_104401 crossref_primary_10_1016_j_nbd_2025_106862 crossref_primary_10_1080_07853890_2025_2493767 crossref_primary_10_1016_j_mito_2023_04_003 crossref_primary_10_3390_ijms241210203 crossref_primary_10_1111_ene_16493 crossref_primary_10_1186_s12964_023_01461_1 crossref_primary_10_1002_jev2_70047 crossref_primary_10_1016_j_prp_2023_154718 crossref_primary_10_1038_s41398_023_02721_x crossref_primary_10_1002_jev2_12489 crossref_primary_10_1007_s11103_021_01157_5 crossref_primary_10_3390_biom13010165 crossref_primary_10_1016_j_isci_2025_112661 crossref_primary_10_1016_j_freeradbiomed_2022_12_083 crossref_primary_10_1016_j_jconrel_2025_114068 crossref_primary_10_1016_j_jneuroim_2023_578064 crossref_primary_10_1002_biot_202200575 crossref_primary_10_3390_ijms24031924 crossref_primary_10_1177_0271678X251338971 crossref_primary_10_1016_j_arr_2024_102549 crossref_primary_10_1002_cbin_11691 crossref_primary_10_3389_fcell_2021_625020 crossref_primary_10_1016_j_cca_2025_120125 crossref_primary_10_1016_j_mito_2022_02_003 crossref_primary_10_1111_jnc_16011 crossref_primary_10_1111_acel_14356 crossref_primary_10_1016_j_dcmed_2023_10_008 crossref_primary_10_3390_ijms24065915 crossref_primary_10_1002_jev2_12320 crossref_primary_10_1007_s10616_024_00634_1 crossref_primary_10_3233_JAD_215666 crossref_primary_10_3389_fgene_2023_1321280 crossref_primary_10_1111_acel_14359 crossref_primary_10_1186_s12951_024_02750_8 crossref_primary_10_1186_s12964_025_02042_0
Cites_doi	10.1073/pnas.1704862114 10.1038/s41598-017-01386-z 10.1038/s41556-018-0250-9 10.1016/j.yexcr.2010.04.006 10.3402/jev.v4.27066 10.1002/eji.201343921 10.1016/j.cell.2013.05.039 10.1080/14789450.2017.1260450 10.1111/trf.15300 10.1038/s41598-019-53640-1 10.1007/s00439-014-1458-9 10.3748/wjg.v10.i11.1560 10.1038/ncomms9472 10.1126/science.1112125 10.1038/nrc3066 10.3402/jev.v5.32945 10.1093/geronj/20.2.151 10.1186/s12864-017-4287-0 10.1016/j.it.2011.01.005 10.1096/fj.201901917RR 10.1016/j.ab.2004.09.036 10.12688/f1000research.10397.1 10.1016/j.cca.2010.01.024 10.1161/CIRCRESAHA.118.314601 10.1016/j.cmet.2019.05.015 10.1080/20013078.2018.1535750 10.1038/nature02517 10.1021/mp500222k 10.1038/nature08780 10.3390/ijms20040805 10.1007/s00702-009-0288-8 10.1097/AOG.0b013e3181867bc0 10.1038/s41574-018-0059-4 10.1038/ni.3704 10.1038/nature12474 10.1038/nrm.2017.125 10.1006/meth.2001.1262 10.1083/jcb.201010024 10.1016/j.ymeth.2008.10.008 10.1016/j.bbamem.2016.02.011 10.1038/nri2975 10.2337/db17-1308 10.1073/pnas.85.8.2444 10.1002/1878-0261.12777 10.1002/wrna.1413 10.1016/j.bbrc.2011.06.067
ContentType	Journal Article
Copyright	Published 2020. This article is a US Government work and is in the public domain in the USA Published 2020. This article is a US Government work and is in the public domain in the USA. COPYRIGHT 2020 John Wiley & Sons, Inc. 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Published 2020. This article is a US Government work and is in the public domain in the USA. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml	– notice: Published 2020. This article is a US Government work and is in the public domain in the USA – notice: Published 2020. This article is a US Government work and is in the public domain in the USA. – notice: COPYRIGHT 2020 John Wiley & Sons, Inc. – notice: 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Published 2020. This article is a US Government work and is in the public domain in the USA. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID	24P AAYXX CITATION NPM 7QP 7TK 8FE 8FH ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO GNUQQ HCIFZ LK8 M7P PHGZM PHGZT PIMPY PKEHL PQEST PQGLB PQQKQ PQUKI PRINS 7X8 5PM
DOI	10.1111/acel.13283
DatabaseName	Wiley Online Library Open Access CrossRef PubMed Calcium & Calcified Tissue Abstracts Neurosciences Abstracts ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central ProQuest Central Student SciTech Premium Collection Biological Sciences Biological Science Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef PubMed Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Biological Science Collection ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Academic UKI Edition Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Central (New) ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) MEDLINE - Academic
DatabaseTitleList	Calcium & Calcified Tissue Abstracts CrossRef PubMed MEDLINE - Academic Publicly Available Content Database
Database_xml	– sequence: 1 dbid: 24P name: Wiley Online Library Open Access (Activated by CARLI) url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database (subscription) url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
DocumentTitleAlternate	LAZO et al
EISSN	1474-9726
EndPage	n/a
ExternalDocumentID	PMC7811845 A705799339 33355987 10_1111_acel_13283 ACEL13283
Genre	article Journal Article Research Support, N.I.H., Intramural
GrantInformation_xml	– fundername: National Institute on Aging funderid: AG000989 – fundername: NIA NIH HHS grantid: AG000989 – fundername: ; grantid: AG000989
GroupedDBID	--- .3N .GA .Y3 05W 0R~ 10A 1OC 23M 24P 2WC 31~ 36B 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52W 52X 53G 5GY 5HH 5LA 5VS 66C 6J9 702 7PT 8-0 8-1 8-3 8-4 8-5 8FE 8FH 8UM 930 A01 A03 AAHHS AAZKR ABCQN ABDBF ABEML ABJNI ACCFJ ACCMX ACGFO ACGFS ACPRK ACSCC ACUHS ACXQS ADBBV ADKYN ADRAZ ADZMN ADZOD AEEZP AEGXH AENEX AEQDE AFBPY AFEBI AFKRA AFZJQ AIAGR AIWBW AJBDE ALMA_UNASSIGNED_HOLDINGS ALUQN AOIJS AVUZU BAWUL BBNVY BCNDV BENPR BFHJK BHPHI BY8 CAG CCPQU COF CS3 D-6 D-7 D-E D-F DIK DR2 E3Z EAD EAP EBD EBS EJD EMB EMK EMOBN EST ESX F00 F01 F04 F5P FIJ GODZA GROUPED_DOAJ GX1 HCIFZ HF~ HOLLA HZ~ IAO IHE IHR IPNFZ ITC IX1 J0M K.9 KQ8 LC2 LC3 LH4 LK8 LP6 LP7 LW6 M48 M7P MK4 N04 N05 N9A O9- OBS OIG OK1 OVD P2P P2X P2Z P4B P4D PIMPY Q11 ROL RPM RX1 SUPJJ SV3 TEORI TR2 TUS UB1 V8K W8V WIN WQJ WRC WXI XG1 YFH YUY ~IA ~WT AAMMB AAYXX AEFGJ AFFHD AGXDD AIDQK AIDYY CITATION O8X PHGZM PHGZT PQGLB NPM 7QP 7TK ABUWG AZQEC DWQXO GNUQQ PKEHL PQEST PQQKQ PQUKI PRINS PUEGO 7X8 5PM
ID	FETCH-LOGICAL-c5433-18eb649516ac6e8e94e3350d60d882de81c57ebd4465fb5fa2d6126c635445cb3
IEDL.DBID	M7P
ISICitedReferencesCount	111
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000601040400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1474-9718 1474-9726
IngestDate	Tue Nov 04 01:49:46 EST 2025 Thu Sep 04 20:35:26 EDT 2025 Sat Aug 23 14:18:55 EDT 2025 Wed Aug 13 09:24:42 EDT 2025 Sat Nov 29 13:14:37 EST 2025 Sat Nov 29 10:05:13 EST 2025 Mon Jul 21 06:07:23 EDT 2025 Tue Nov 18 21:42:01 EST 2025 Sat Nov 29 03:05:16 EST 2025 Wed Jan 22 16:30:34 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	extracellular vesicles exosomes mitochondrial DNA intercellular communication aging microvesicles biomarker circulating cell-free mitochondrial DNA
Language	English
License	Attribution Published 2020. This article is a US Government work and is in the public domain in the USA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c5433-18eb649516ac6e8e94e3350d60d882de81c57ebd4465fb5fa2d6126c635445cb3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Stephanie Lazo and Nicole Noren Hooten contributed equally to this work.
ORCID	0000-0002-8546-2831 0000-0001-8016-3181 0000-0002-1683-3838
OpenAccessLink	https://www.proquest.com/docview/2478349713?pq-origsite=%requestingapplication%
PMID	33355987
PQID	2478349713
PQPubID	1036381
PageCount	15
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_7811845 proquest_miscellaneous_2473421276 proquest_journals_2478350403 proquest_journals_2478349713 gale_infotracmisc_A705799339 gale_infotracacademiconefile_A705799339 pubmed_primary_33355987 crossref_primary_10_1111_acel_13283 crossref_citationtrail_10_1111_acel_13283 wiley_primary_10_1111_acel_13283_ACEL13283
PublicationCentury	2000
PublicationDate	January 2021
PublicationDateYYYYMMDD	2021-01-01
PublicationDate_xml	– month: 01 year: 2021 text: January 2021
PublicationDecade	2020
PublicationPlace	England
PublicationPlace_xml	– name: England – name: London – name: Hoboken
PublicationTitle	Aging cell
PublicationTitleAlternate	Aging Cell
PublicationYear	2021
Publisher	John Wiley & Sons, Inc John Wiley and Sons Inc
Publisher_xml	– name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc
References	2017; 6 2011; 412 2017; 7 2017; 8 2019; 9 2015; 6 2015; 4 2019; 30 2013; 501 2019; 59 2010; 464 2005; 337 2011; 11 2011; 32 2019; 125 2020; 34 2018; 67 2014; 133 2001; 25 2011; 193 2017; 114 2014; 44 2004; 429 2004; 10 2018; 7 2016; 5 2018; 19 1965; 20 2010; 20 2010; 316 2019; 20 2017; 14 2020 2010; 117 2019; 21 2016; 1858 2010; 411 2019 2008; 46 2005; 309 2017; 18 1988; 85 2013; 153 2008; 112 2014; 11 2018; 14 e_1_2_9_31_1 e_1_2_9_50_1 e_1_2_9_10_1 e_1_2_9_35_1 e_1_2_9_12_1 e_1_2_9_14_1 e_1_2_9_39_1 e_1_2_9_16_1 e_1_2_9_37_1 e_1_2_9_18_1 Evans M. K. (e_1_2_9_6_1) 2010; 20 e_1_2_9_41_1 e_1_2_9_20_1 e_1_2_9_22_1 e_1_2_9_24_1 e_1_2_9_43_1 Xu J. (e_1_2_9_45_1) 2020 e_1_2_9_8_1 e_1_2_9_4_1 e_1_2_9_2_1 e_1_2_9_26_1 e_1_2_9_49_1 e_1_2_9_28_1 e_1_2_9_47_1 e_1_2_9_30_1 e_1_2_9_11_1 e_1_2_9_34_1 e_1_2_9_13_1 e_1_2_9_32_1 e_1_2_9_15_1 e_1_2_9_38_1 e_1_2_9_17_1 e_1_2_9_36_1 e_1_2_9_19_1 e_1_2_9_42_1 e_1_2_9_40_1 e_1_2_9_21_1 e_1_2_9_46_1 e_1_2_9_23_1 e_1_2_9_44_1 e_1_2_9_7_1 e_1_2_9_5_1 R Core Team (e_1_2_9_33_1) 2019 e_1_2_9_3_1 e_1_2_9_9_1 e_1_2_9_25_1 e_1_2_9_27_1 e_1_2_9_48_1 e_1_2_9_29_1
References_xml	– volume: 6 start-page: 169 year: 2017 article-title: Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases publication-title: F1000Research – volume: 20 start-page: 267 issue: 3 year: 2010 end-page: 275 article-title: Healthy aging in neighborhoods of diversity across the life span (HANDLS): Overcoming barriers to implementing a longitudinal, epidemiologic, urban study of health, race, and socioeconomic status publication-title: Ethnicity and Disease – volume: 133 start-page: 1149 issue: 9 year: 2014 end-page: 1159 article-title: Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly publication-title: Human Genetics – volume: 44 start-page: 1552 issue: 5 year: 2014 end-page: 1562 article-title: Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for "inflamm‐aging" publication-title: European Journal of Immunology – volume: 21 start-page: 9 issue: 1 year: 2019 end-page: 17 article-title: Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell‐to‐cell communication publication-title: Nature Cell Biology – volume: 11 start-page: 389 issue: 6 year: 2011 end-page: 402 article-title: Mitochondria in innate immune responses publication-title: Nature Reviews Immunology – volume: 337 start-page: 89 issue: 1 year: 2005 end-page: 97 article-title: Multiplex polymerase chain reaction for simultaneous quantitation of human nuclear, mitochondrial, and male Y‐chromosome DNA: Application in human identification publication-title: Analytical Biochemistry – volume: 7 start-page: 1535750 issue: 1 year: 2018 article-title: Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines publication-title: Journal of Extracellular Vesicles – volume: 85 start-page: 2444 issue: 8 year: 1988 end-page: 2448 article-title: Improved tools for biological sequence comparison publication-title: Proceedings of the National Academy of Sciences of the United States of America – volume: 429 start-page: 417 issue: 6990 year: 2004 end-page: 423 article-title: Premature ageing in mice expressing defective mitochondrial DNA polymerase publication-title: Nature – volume: 153 start-page: 1194 issue: 6 year: 2013 end-page: 1217 article-title: The hallmarks of aging publication-title: Cell – volume: 464 start-page: 104 issue: 7285 year: 2010 end-page: 107 article-title: Circulating mitochondrial DAMPs cause inflammatory responses to injury publication-title: Nature – year: 2020 article-title: DNA in extracellular vesicles: biological and clinical aspects publication-title: Molecular Oncology – start-page: 1 issue: 355 year: 2020 end-page: 8 article-title: Mortality in the United States, 2018 publication-title: NCHS Data Brief – volume: 20 start-page: 151 year: 1965 end-page: 153 article-title: The free radical theory of aging: Effect of age on serum copper levels publication-title: The Journal of Gerontology – volume: 30 start-page: 329 issue: 2 year: 2019 end-page: 342e325 article-title: Extracellular vesicle‐contained eNAMPT delays aging and extends lifespan in mice publication-title: Cell Metabolism – volume: 11 start-page: 426 issue: 6 year: 2011 end-page: 437 article-title: Cell‐free nucleic acids as biomarkers in cancer patients publication-title: Nature Reviews Cancer – volume: 411 start-page: 592 issue: 7–8 year: 2010 end-page: 596 article-title: Mitochondrial DNA copy number in peripheral blood is associated with cognitive function in apparently healthy elderly women publication-title: Clinica Chimica Acta – volume: 46 start-page: 263 issue: 4 year: 2008 end-page: 268 article-title: Quantification of random mutations in the mitochondrial genome publication-title: Methods – volume: 5 start-page: 32945 year: 2016 article-title: Techniques used for the isolation and characterization of extracellular vesicles: Results of a worldwide survey publication-title: Journal of Extracellular Vesicles – volume: 114 start-page: E9066 issue: 43 year: 2017 end-page: e9075 article-title: Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy‐resistant breast cancer publication-title: Proceedings of the National Academy of Sciences of the United States of America – volume: 112 start-page: 843 issue: 4 year: 2008 end-page: 850 article-title: Levels of circulating cell‐free nuclear and mitochondrial DNA in benign and malignant ovarian tumors publication-title: Obstetrics and Gynecology – volume: 34 start-page: 3616 issue: 3 year: 2020 end-page: 3630 article-title: Blood contains circulating cell‐free respiratory competent mitochondria publication-title: The FASEB Journal – volume: 25 start-page: 402 issue: 4 year: 2001 end-page: 408 article-title: Analysis of relative gene expression data using real‐time quantitative PCR and the 2(‐Delta Delta C(T)) Method publication-title: Methods – volume: 117 start-page: 1 issue: 1 year: 2010 end-page: 4 article-title: Astrocytes and Glioblastoma cells release exosomes carrying mtDNA publication-title: Journal of Neural Transmission (Vienna) – year: 2019 – volume: 14 start-page: 69 issue: 1 year: 2017 end-page: 95 article-title: Proteomic insights into extracellular vesicle biology – defining exosomes and shed microvesicles publication-title: Expert Review of Proteomics – volume: 18 start-page: 890 issue: 1 year: 2017 article-title: Independent impacts of aging on mitochondrial DNA quantity and quality in humans publication-title: BMC Genomics – volume: 10 start-page: 1560 issue: 11 year: 2004 end-page: 1564 article-title: Quantitative detection of common deletion of mitochondrial DNA in hepatocellular carcinoma and hepatocellular nodular hyperplasia publication-title: World Journal of Gastroenterology – volume: 11 start-page: 2864 issue: 8 year: 2014 end-page: 2875 article-title: Antiproliferative effect of ASC‐J9 delivered by PLGA nanoparticles against estrogen‐dependent breast cancer cells publication-title: Molecular Pharmaceutics – volume: 316 start-page: 1977 issue: 12 year: 2010 end-page: 1984 article-title: C2C12 myoblasts release micro‐vesicles containing mtDNA and proteins involved in signal transduction publication-title: Experimental Cell Research – volume: 193 start-page: 809 issue: 5 year: 2011 end-page: 818 article-title: Mitochondrial DNA mutations in disease and aging publication-title: Journal of Cell Biology – volume: 18 start-page: 488 issue: 5 year: 2017 end-page: 498 article-title: Mitochondria are the powerhouses of immunity publication-title: Nature Immunology – volume: 309 start-page: 481 issue: 5733 year: 2005 end-page: 484 article-title: Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging publication-title: Science – volume: 32 start-page: 157 issue: 4 year: 2011 end-page: 164 article-title: Emerging role of damage‐associated molecular patterns derived from mitochondria in inflammation publication-title: Trends in Immunology – volume: 7 start-page: 1342 issue: 1 year: 2017 article-title: Age‐related changes in plasma extracellular vesicle characteristics and internalization by leukocytes publication-title: Scientific Reports – volume: 4 start-page: 27066 year: 2015 article-title: Biological properties of extracellular vesicles and their physiological functions publication-title: Journal of Extracellular Vesicles – volume: 412 start-page: 1 issue: 1 year: 2011 end-page: 7 article-title: Mitochondrial DNA as a non‐invasive biomarker: Accurate quantification using real time quantitative PCR without co‐amplification of pseudogenes and dilution bias publication-title: Biochemical and Biophysical Research Communications – volume: 59 start-page: 2403 issue: 7 year: 2019 end-page: 2414 article-title: Platelet‐derived extracellular vesicles convey mitochondrial DAMPs in platelet concentrates and their levels are associated with adverse reactions publication-title: Transfusion – volume: 9 start-page: 17582 issue: 1 year: 2019 article-title: Association of extracellular vesicle protein cargo with race and clinical markers of mortality publication-title: Scientific Reports – volume: 19 start-page: 213 year: 2018 article-title: Shedding light on the cell biology of extracellular vesicles publication-title: Nature Reviews Molecular Cell Biology – volume: 1858 start-page: 1139 issue: 6 year: 2016 end-page: 1151 article-title: Exosomes and other extracellular vesicles in neural cells and neurodegenerative diseases publication-title: Biochimica Et Biophysica Acta – volume: 67 start-page: 2377 issue: 11 year: 2018 end-page: 2388 article-title: Altered extracellular vesicle concentration, cargo, and function in diabetes publication-title: Diabetes – volume: 6 start-page: 8472 year: 2015 article-title: Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs publication-title: Nature Communications – volume: 20 start-page: 805 issue: 4 year: 2019 article-title: Mitochondrial dysfunction and aging: Insights from the analysis of extracellular vesicles publication-title: International Journal of Molecular Sciences – volume: 8 issue: 4 year: 2017 article-title: RNA in extracellular vesicles publication-title: Wiley Interdisciplinary Reviews: RNA – volume: 125 start-page: 43 issue: 1 year: 2019 end-page: 52 article-title: Mitochondria are a subset of extracellular vesicles released by activated monocytes and induce type I IFN and TNF responses in endothelial cells publication-title: Circulation Research – volume: 501 start-page: 412 issue: 7467 year: 2013 end-page: 415 article-title: Germline mitochondrial DNA mutations aggravate ageing and can impair brain development publication-title: Nature – volume: 14 start-page: 576 issue: 10 year: 2018 end-page: 590 article-title: Inflammaging: A new immune‐metabolic viewpoint for age‐related diseases publication-title: Nature Reviews Endocrinology – ident: e_1_2_9_35_1 doi: 10.1073/pnas.1704862114 – ident: e_1_2_9_4_1 doi: 10.1038/s41598-017-01386-z – ident: e_1_2_9_23_1 doi: 10.1038/s41556-018-0250-9 – ident: e_1_2_9_12_1 doi: 10.1016/j.yexcr.2010.04.006 – ident: e_1_2_9_46_1 doi: 10.3402/jev.v4.27066 – ident: e_1_2_9_31_1 doi: 10.1002/eji.201343921 – ident: e_1_2_9_20_1 doi: 10.1016/j.cell.2013.05.039 – ident: e_1_2_9_10_1 doi: 10.1080/14789450.2017.1260450 – ident: e_1_2_9_22_1 doi: 10.1111/trf.15300 – ident: e_1_2_9_26_1 doi: 10.1038/s41598-019-53640-1 – ident: e_1_2_9_24_1 doi: 10.1007/s00439-014-1458-9 – ident: e_1_2_9_37_1 doi: 10.3748/wjg.v10.i11.1560 – ident: e_1_2_9_29_1 doi: 10.1038/ncomms9472 – ident: e_1_2_9_17_1 doi: 10.1126/science.1112125 – ident: e_1_2_9_36_1 doi: 10.1038/nrc3066 – ident: e_1_2_9_9_1 doi: 10.3402/jev.v5.32945 – ident: e_1_2_9_13_1 doi: 10.1093/geronj/20.2.151 – ident: e_1_2_9_50_1 doi: 10.1186/s12864-017-4287-0 – start-page: 1 issue: 355 year: 2020 ident: e_1_2_9_45_1 article-title: Mortality in the United States, 2018 publication-title: NCHS Data Brief – ident: e_1_2_9_16_1 doi: 10.1016/j.it.2011.01.005 – ident: e_1_2_9_2_1 doi: 10.1096/fj.201901917RR – ident: e_1_2_9_43_1 doi: 10.1016/j.ab.2004.09.036 – volume: 20 start-page: 267 issue: 3 year: 2010 ident: e_1_2_9_6_1 article-title: Healthy aging in neighborhoods of diversity across the life span (HANDLS): Overcoming barriers to implementing a longitudinal, epidemiologic, urban study of health, race, and socioeconomic status publication-title: Ethnicity and Disease – ident: e_1_2_9_3_1 doi: 10.12688/f1000research.10397.1 – ident: e_1_2_9_18_1 doi: 10.1016/j.cca.2010.01.024 – ident: e_1_2_9_32_1 doi: 10.1161/CIRCRESAHA.118.314601 – ident: e_1_2_9_47_1 doi: 10.1016/j.cmet.2019.05.015 – ident: e_1_2_9_38_1 doi: 10.1080/20013078.2018.1535750 – ident: e_1_2_9_39_1 doi: 10.1038/nature02517 – ident: e_1_2_9_41_1 doi: 10.1021/mp500222k – ident: e_1_2_9_49_1 doi: 10.1038/nature08780 – ident: e_1_2_9_30_1 doi: 10.3390/ijms20040805 – ident: e_1_2_9_11_1 doi: 10.1007/s00702-009-0288-8 – ident: e_1_2_9_48_1 doi: 10.1097/AOG.0b013e3181867bc0 – ident: e_1_2_9_7_1 doi: 10.1038/s41574-018-0059-4 – ident: e_1_2_9_25_1 doi: 10.1038/ni.3704 – ident: e_1_2_9_34_1 doi: 10.1038/nature12474 – ident: e_1_2_9_40_1 doi: 10.1038/nrm.2017.125 – volume-title: R: A language and environment for statistical computing (Version 3.6) year: 2019 ident: e_1_2_9_33_1 – ident: e_1_2_9_19_1 doi: 10.1006/meth.2001.1262 – ident: e_1_2_9_27_1 doi: 10.1083/jcb.201010024 – ident: e_1_2_9_42_1 doi: 10.1016/j.ymeth.2008.10.008 – ident: e_1_2_9_14_1 doi: 10.1016/j.bbamem.2016.02.011 – ident: e_1_2_9_44_1 doi: 10.1038/nri2975 – ident: e_1_2_9_8_1 doi: 10.2337/db17-1308 – ident: e_1_2_9_28_1 doi: 10.1073/pnas.85.8.2444 – ident: e_1_2_9_5_1 doi: 10.1002/1878-0261.12777 – ident: e_1_2_9_15_1 doi: 10.1002/wrna.1413 – ident: e_1_2_9_21_1 doi: 10.1016/j.bbrc.2011.06.067
SSID	ssj0017903
Score	2.612251
Snippet	The mitochondrial free radical theory of aging suggests that accumulating oxidative damage to mitochondria and mitochondrial DNA (mtDNA) plays a central role...
SourceID	pubmedcentral proquest gale pubmed crossref wiley
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	e13283
SubjectTerms	Age Aging Analysis B cells biomarker Breast cancer Cell signaling circulating cell‐free mitochondrial DNA Communications systems Deoxyribonucleic acid Design DNA exosomes Extracellular vesicles Genes Genomes intercellular communication Lipids Microscopy microvesicles Mitochondrial DNA Morphology Nanoparticles Older people Original Physiology Plasma Protein binding Proteins
SummonAdditionalLinks	– databaseName: Wiley Online Library Open Access dbid: 24P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR1da9RAcKhVwRe_tdEqEQVRiCS336APR23xQY8-KPQtZHfn8OBI5a4t9N87s8nFS1FBfEuYyZKdnZmd2Z0PgFdBYTl3wRdYoSMHRZeFt_SqtGgmEWnLsE1qNmFmM3ty4o534P0mF6arDzEcuLFkJH3NAt749ZaQNwGX78iXsuIaXK8qYZinJ_J4uEMwLvVFrqSRhSMV3Bcn5TieX9-OtqOrSnlrV7oaMbltyaat6OjO_03iLtzuTdB82vHMPdjB9j7c7JpSXj6AD19IyEkptpF5M_84m-aLNicdvuJhlhy2ml_gOoXT5RE5tZIe-Dw3J930EL4dHX49-FT0TRaKoKQQRWXRa_KSKt0EjRadRCFUGXUZyfiOaKugDPrIhdXmXs1pBcko0oEMFSlV8OIR7LanLe5BrpvoK9IYce6cNJ5WWQlT-RA12VixxAzebGhdh74COTfCWNYbT4TnUSdyZPBywP3R1d34LdZrXrKahZGp0PQ5BfQ_XNaqnhrOtXVCuAz2R5gkRGEM3ix63Qvxup5I7kJCrCP-DFakBAn8YgDzwBy31uLpecIRfOdudAaPOxYapiOIzspZk4EZMdeAwJW_x5B28T1VAOf0YCtVBm8Tc_2FQvX04PBzenryL8hP4daEg3fSWdM-7J6tzvEZ3AgXZ4v16nmSs5_mlikQ priority: 102 providerName: Wiley-Blackwell
Title	Mitochondrial DNA in extracellular vesicles declines with age
URI	https://onlinelibrary.wiley.com/doi/abs/10.1111%2Facel.13283 https://www.ncbi.nlm.nih.gov/pubmed/33355987 https://www.proquest.com/docview/2478349713 https://www.proquest.com/docview/2478350403 https://www.proquest.com/docview/2473421276 https://pubmed.ncbi.nlm.nih.gov/PMC7811845
Volume	20
WOSCitedRecordID	wos000601040400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1474-9726 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017903 issn: 1474-9718 databaseCode: DOA dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1474-9726 dateEnd: 20221231 omitProxy: false ssIdentifier: ssj0017903 issn: 1474-9718 databaseCode: M7P dateStart: 20190101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1474-9726 dateEnd: 20221231 omitProxy: false ssIdentifier: ssj0017903 issn: 1474-9718 databaseCode: BENPR dateStart: 20190101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database (subscription) customDbUrl: eissn: 1474-9726 dateEnd: 20221231 omitProxy: false ssIdentifier: ssj0017903 issn: 1474-9718 databaseCode: PIMPY dateStart: 20190101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVWIB databaseName: Wiley Online Library Free Content customDbUrl: eissn: 1474-9726 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017903 issn: 1474-9718 databaseCode: WIN dateStart: 20020101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Open Access (Activated by CARLI) customDbUrl: eissn: 1474-9726 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017903 issn: 1474-9718 databaseCode: 24P dateStart: 20020101 isFulltext: true titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html providerName: Wiley-Blackwell
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR1db9NAzGIbSLzwDQuMKggkBFIgyX0_IFRGJyaxKEIgylOU3F21SlU62m0S_x77mpZlgr3wEiW1E9Vnn8_2-WyAF1b4dGJsk_jMG3RQZJo0Gh-FZHXuPC4Zug7NJlRR6PHYlF3AbdmlVa51YlDUbm4pRv4259QSwqBP9f7kZ0Jdo2h3tWuhsQU7VCUhD6l75WYXQZnQGTnjiif4pu7Kk1ImT2397A16Ypr1FqTLavnCunQ5Z_KiLRsWo4Pb_0vGHbjVmaHxcCU3d-Gab-_BjVVjyl_34d0RTnRUjK0j-Yw_FsN42saoxxdE0YxSV-NzvwwpdbHzdLwSbyimG6N-egDfDkZf9z8lXaOFxArOWJJp30j0lDJZW-m1N9wzJlInU4cGuPM6s0L5xlFxtUkjJshFNIykRWOFc2Eb9hC223nrdyGWtWsy1BpuYgxXDXJaMJU11km0s1zqI3i1Hu3KdlXIqRnGrFp7I0RHFTgTwfMN7smq9sZfsV4S0yqakDQKdXeuAP8PlbaqhorO2xrGTAR7PUycSLYPXrOs6ibysvrDr3-DBSpCBD_bgOnDlLvW-vlZwGG0765kBI9WQrQhh-E4C6NVBKonXhsEqv7dh7TT41AFnI4Iay4ieB0E8YoRqob7o8_h7vHVJD6Bmzml7IQI0x5sny7O_FO4bs9Pp8vFALZyXuJVjfUAdj6MivLLIIQwBmHW4W_l4VH5A5--Hxa_ATmOMcs
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VLQguvB-BAkGAEEiBJI5j-1ChVR_qqrurPRSpnEJie8VKq2zZbYv6p_iNzDgPmgp664FbIo8ie_J5HvY8AN5obsOp0kVgI6vQQUnDoJD4ylOWx8aiypC5azYhxmN5eKgma_CryYWhsMpGJjpBbRaazsg_xQm1hFDoU30--hFQ1yi6XW1aaFSw2LdnP9FlW20OtvH_vo3j3Z2Drb2g7ioQaJ4wFkTSFim6BVGa69RKqxLLGA9NGhq0No2VkebCFoYqiU0LPsUpoxWQatTMScJ1wfC712A9IbD3YH0yGE2-tvcWQrlezFEikgDnKuuCqBQ7lGs7_4i-n2QdFXhREZzThBejNM9bz0797d753xh3F27Xhrbfr3bGPViz5X24UbXePHsAmyMUZSj6S0M70N8e9_1Z6aOmWhIH5xSc65_alQsa9I2lBFJ8oFNrHyXwQ_hyJXN_BL1yUdon4Ke5KSKUi2aqVCIKxDJnIiq0SdGSNKH14H3zdzNd11mndh_zrPG3aB2ZQ4IHr1vao6q6yF-p3hFIMhI5xIW8zpzA-VDxrqwvKKNYMaY82OhQoqjQ3eEGIlktqlbZH3z8e5ijqMfhV-0wfZii80q7OHE0jCILROrB4wq07XIY8pkrKTwQHTi3BFTfvDtSzr67OueUBC0T7sEHB_xLOJT1t3aG7unp5Ut8CTf3DkbDbDgY7z-DWzEFKLnztA3oHS9P7HO4rk-PZ6vli3pn-_DtqvfEbwdLh7E
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9RAEB-0fuCLn1VTq0YUpIVIcvuVffDhaHso1uMeFPoWkt0JHhxpuWsL_ved2eTipaggviXMJGRnZ2ZnNzO_AXjnFKa1dVWCGVraoOg0qXK6VVqUI4-0ZORlaDZhptP85MTOutwcroVp8SH6Aze2jOCv2cDxzNcbVl46XHygzVQubsItqcjJMrCznPU_EYwNjZEzaWRiidyhk3Iiz69nB-vRda-8sSxdT5ncDGXDWjR58J-jeAj3uyA0Hrda8whuYPMY7rRtKX8-gY9fyczJLTaetTM-nI7jeROTF1_yaxacuBpf4iok1MUeubiSLvhENybvtA3fJ0ffDj4lXZuFxCkpRJLlWGnaJ2W6dBpztBKFUKnXqafw22OeOWWw8gytVleqpjmksEg7ClWkVK4ST2GrOW3wOcS69FVGPsPX1kpT0TwrYbLKeU1Rlk8xgr21sAvXYZBzK4xFsd6L8DiKII4I3va8Zy3yxm-53vOcFWyOLIWyqyqg72Fgq2JsuNrWCmEj2B1wkhm5IXk960VnxqtiJLkPCemO-DNZkRsk8puezC_mzLUGTy8Cj-C_7kZH8KzVoX44guSsbG4iMAPt6hkY-3tIaeY_AgY4FwjnUkWwH7TrLxIqxgdHx-Fq51-YX8Pd2eGkOP48_fIC7o04kyccPO3C1vnyAl_CbXd5Pl8tXwWbuwLfLix2
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mitochondrial+DNA+in+extracellular+vesicles+declines+with+age&rft.jtitle=Aging+cell&rft.au=Lazo%2C+Stephanie&rft.au=Hooten%2C+Nicole+Noren&rft.au=Green%2C+Jamal&rft.au=Eitan%2C+Erez&rft.date=2021-01-01&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.issn=1474-9718&rft.volume=20&rft.issue=1&rft_id=info:doi/10.1111%2Facel.13283&rft.externalDocID=A705799339
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1474-9718&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1474-9718&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1474-9718&client=summon