MITF controls the TCA cycle to modulate the melanoma hypoxia response

In response to the dynamic intra‐tumor microenvironment, melanoma cells adopt distinct phenotypic states associated with differential expression of the microphthalmia‐associated transcription factor (MITF). The response to hypoxia is driven by hypoxia‐inducible transcription factors (HIFs) that repr...

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Bibliographic Details
Published in:	Pigment Cell & Melanoma Research Vol. 32; no. 6; pp. 792 - 808
Main Authors:	Louphrasitthiphol, Pakavarin, Ledaki, Ioanna, Chauhan, Jagat, Falletta, Paola, Siddaway, Robert, Buffa, Francesca M., Mole, David R., Soga, Tomoyoshi, Goding, Colin R.
Format:	Journal Article
Language:	English
Published:	England Wiley 01.11.2019 Wiley Subscription Services, Inc John Wiley and Sons Inc
Subjects:	Angiogenesis Biotechnology Cell Line, Tumor Citric Acid Cycle Deoxyribonucleic acid DNA Gene expression Gene Expression Regulation, Neoplastic Genes Genome, Human genomewide glucose limitation Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Melanoma Melanoma - genetics Melanoma - pathology Metabolism Microphthalmia-Associated Transcription Factor Microphthalmia-Associated Transcription Factor - metabolism MITF Neoplasm Invasiveness Original Original Articles Succinate Dehydrogenase Succinate Dehydrogenase - metabolism Transcription factors transcription factors, TCA cycle, hypoxia, genomewide, glucose limitation, hypoxia, melanoma, MITF Tricarboxylic acid cycle Tumor Hypoxia Tumor Hypoxia - genetics Up-Regulation Up-Regulation - genetics hypoxia melanoma genomewide glucose limitation MITF
ISSN:	1755-1471, 1755-148X, 1755-148X
Online Access:	Get full text
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