Quantitation of melatonin and n-acetylserotonin in human plasma by nanoflow LC-MS/MS and electrospray LC-MS/MS

Melatonin (MEL) and its chemical precursor N‐acetylserotonin (NAS) are believed to be potential biomarkers for sleep‐related disorders. Measurement of these compounds, however, has proven to be difficult due to their low circulating levels, especially that of NAS. Few methods offer the sensitivity,...

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Vydáno v:	Journal of mass spectrometry. Ročník 47; číslo 3; s. 277 - 285
Hlavní autoři:	Carter, Melissa D., Wade Calcutt, M., Malow, Beth A., Rose, Kristie L., Hachey, David L.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Chichester, UK John Wiley & Sons, Ltd 01.03.2012 Wiley
Témata:	Adult Analysis autism spectrum disorder Biological and medical sciences Child Child clinical studies Child, Preschool Chromatography, Liquid - methods Developmental disorders Female General pharmacology Humans Infantile autism Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Melatonin Melatonin - blood Melatonin - pharmacokinetics Miscellaneous. Technology N-acetylserotonin Nanoflow LC-MS/MS Nanotechnology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reproducibility of Results Serotonin - analogs & derivatives Serotonin - blood Serotonin - pharmacokinetics Spectrometry, Mass, Electrospray Ionization - methods Tandem Mass Spectrometry - methods Biological fluid Tandem mass spectrometry Melatonin Chemical analysis Aminoacid derivative hormone HPLC chromatography Tryptamine derivatives N-acetylserotonin Developmental disorder Electrospray Blood Blood plasma Clinical biology Biosynthesis precursor autism spectrum disorder Child Quantitative analysis Human Healthy subject Coupled method Oral administration Patient Endogenous substance Autism Nanoflow LC-MS/MS Indole derivatives Pharmacokinetics
ISSN:	1076-5174, 1096-9888, 1096-9888
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