Exploring genomic alteration in pediatric cancer using ProteinPaint

The pediatric data set consists of 27,188 validated somatic coding lesions acquired at diagnosis or relapse from 17 subtypes of pediatric cancer, 252 pathogenic or loss-of-function germline lesions detected in >1,000 pediatric patients with cancer of 21 subtypes6 and RNA sequencing (RNA-seq) data...

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Vydáno v:Nature genetics Ročník 48; číslo 1; s. 4 - 6
Hlavní autoři: Zhou, Xin, Edmonson, Michael N, Wilkinson, Mark R, Patel, Aman, Wu, Gang, Liu, Yu, Li, Yongjin, Zhang, Zhaojie, Rusch, Michael C, Parker, Matthew, Becksfort, Jared, Downing, James R, Zhang, Jinghui
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Nature Publishing Group US 01.01.2016
Nature Publishing Group
Témata:
45
45/23
631/114/794
692/699/67
Agriculture
Animal Genetics and Genomics
Biomedicine
Cancer
Cancer Research
Cancer treatment
Child
Children & youth
correspondence
Databases, Genetic
Gene expression
Gene Expression Regulation, Neoplastic
Gene Function
Genome, Human
Genomes
Human Genetics
Humans
Kinases
Lesions
Medical research
Mutation
Neoplasms - genetics
Pediatrics
Proteins
Proteins - genetics
Software
Studies
Tumors
User-Computer Interface
Visualization
ISSN:1061-4036, 1546-1718, 1546-1718
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Popis
Shrnutí:The pediatric data set consists of 27,188 validated somatic coding lesions acquired at diagnosis or relapse from 17 subtypes of pediatric cancer, 252 pathogenic or loss-of-function germline lesions detected in >1,000 pediatric patients with cancer of 21 subtypes6 and RNA sequencing (RNA-seq) data for 928 pediatric tumors from 36 subtypes (Supplementary Note). Data in mutation annotation format (MAF) generated by studies such as The Cancer Genome Atlas (TCGA) or individual research laboratories can be uploaded to ProteinPaint to enable data visualization and cross-study comparison for the broad genetic research community (Supplementary Fig. 8 and Supplementary Tutorial).
Bibliografie:SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
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ISSN:1061-4036
1546-1718
1546-1718
DOI:10.1038/ng.3466