SMC complexes differentially compact mitotic chromosomes according to genomic context

Structural maintenance of chromosomes (SMC) protein complexes are key determinants of chromosome conformation. Using Hi-C and polymer modelling, we study how cohesin and condensin, two deeply conserved SMC complexes, organize chromosomes in the budding yeast Saccharomyces cerevisiae . The canonical...

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Veröffentlicht in:	Nature cell biology Jg. 19; H. 9; S. 1071 - 1080
Hauptverfasser:	Schalbetter, Stephanie Andrea, Goloborodko, Anton, Fudenberg, Geoffrey, Belton, Jon-Matthew, Miles, Catrina, Yu, Miao, Dekker, Job, Mirny, Leonid, Baxter, Jonathan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.09.2017 Nature Publishing Group
Schlagworte:	45/22 45/23 631/1647/2017/2214 631/1647/514/1948 631/80/641/1655 631/80/641/2351 631/80/641/2358 Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Analysis Baking yeast Cancer Research Cell Biology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chromatids Chromatin Chromatin - chemistry Chromatin - genetics Chromatin - metabolism Chromatin Assembly and Disassembly Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosome Structures Chromosomes Chromosomes, Fungal - chemistry Chromosomes, Fungal - genetics Chromosomes, Fungal - metabolism Cohesin Cohesins Cohesion Compacting Compaction Compacts Computer Simulation Condensin Developmental Biology DNA, Fungal - chemistry DNA, Fungal - genetics DNA, Fungal - metabolism DNA, Ribosomal - chemistry DNA, Ribosomal - genetics DNA, Ribosomal - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Human chromosomes Life Sciences Mitosis Models, Genetic Models, Molecular Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Nucleic Acid Conformation Physiological aspects Polymers Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sister chromatids Stem Cells Structure Structure-Activity Relationship Yeast United States
ISSN:	1465-7392, 1476-4679, 1476-4679
Online-Zugang:	Volltext
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